Kentucky is currently home to 1068 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Auricular Acupuncture vs SOC in Migraine HA
NCT02681211
Recruiting
Patients with migraine headache will be offered the opportunity to participate in this randomized study evaluating auricular acupuncture versus standard treatment for migraine headaches for patients in the pediatric emergency department (ED).
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
10/05/2023
Locations: Norton Children's Hospital, Louisville, Kentucky
Conditions: Migraine Headache
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A Precision Medicine Approach to Target Engagement for Emotion Regulation
NCT05651295
Recruiting
The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Emotional Regulation, Depression, Anxiety, Borderline Personality Disorder, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Eating Disorders
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PMCFU of an Annular Closure System
NCT05467072
Recruiting
The purpose of this retrospective chart review study is to collect the data that will be used to provide clinical evidence to support the post-market surveillance program.
Gender:
ALL
Ages:
All
Trial Updated:
09/27/2023
Locations: Orthopedic Institute of Western Kentucy, Paducah, Kentucky
Conditions: Lumbar Disc Herniation
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PK Study of Single-Dose ZTI-01 in Children (<12 Years of Age)
NCT03709914
Recruiting
Phase 1 study, a single dose of ZTI-01 given to pediatric subjects (under 12 years of age) who require antibiotic therapy to see what the body does to the drug (pharmacokinetics) and to compare if these effects are similar to those observed in adults at a 6g ZTI-01 dose. Study will help establish pediatric dosing in younger children by age cohort. This is a multiple-center, open-label, PK study of ZTI-01 (fosfomycin for injection) single dose scaled by allometric weight-modeling from an adult ZT... Read More
Gender:
ALL
Ages:
11 years and below
Trial Updated:
09/14/2023
Locations: Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky
Conditions: Pediatric ALL
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OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
NCT05405374
Recruiting
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar interbody fusion (LIF) by means of an intra-patient control model.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
08/25/2023
Locations: Orthopaedic Institute of Western Kentucky, Paducah, Kentucky
Conditions: Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
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Antidepressant Discontinuation in Treatment Resistant Depression
NCT03786614
Recruiting
The purpose of this study is to compare the effects on depressive symptoms of subjects who discontinue serotonergic antidepressants (a certain type of antidepressant, such as Prozac, that works on serotonin receptors in the brain) with the effects on depressive symptoms of subjects who continue to take serotonergic antidepressants. During this study, subjects will also be presented with the opportunity to undergo genetic testing for the serotonin gene transporter which has a short or long form.... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/16/2023
Locations: University of Louisville, Department of Psychiatry and Behavioral Sciences, Louisville, Kentucky
Conditions: Treatment Resistant Depression
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Venetoclax and Lintuzumab-Ac225 in AML Patients
NCT03867682
Recruiting
The study is a multicenter, open label Phase I/II trial. 1. To determine the maximum tolerated dose (MTD) of lintuzumab-Ac225 added to venetoclax for patients with CD33 positive relapsed/refractory AML. (Phase 1 portion) 2. To assess the percentage of patients with CR, CRh, or Overall Response (CR + CRh), up to 6 months after the start of treatment without receiving other AML therapies. (Phase 2 portion)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Acute Myeloid Leukemia, Relapsed Adult AML
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A Safety and Pharmacokinetics Study of IDP-118 Lotion in Pediatric Participants With Plaque Psoriasis
NCT03988439
Recruiting
This study is to evaluate the safety, the systemic exposure, and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-118 lotion in pediatric participants with moderate to severe plaque psoriasis.
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
07/25/2023
Locations: Bausch Site 3, Louisville, Kentucky
Conditions: Psoriasis
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BESTMED: Observational Evaluation of Second Line Therapy Medications in Diabetes
NCT05161429
Recruiting
An observational study of electronic patient data to compare diabetes medications and to determine which ones offer the best balance of risks and benefits.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
06/16/2023
Locations: Humana, Lexington, Kentucky
Conditions: Diabetes Mellitus, Type 2
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Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma
NCT03787602
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Merkel Cell Carcinoma (MCC) who have failed treatment with at least one anti-PD-1 or anti-PD-L1 immunotherapy or in combination with avelumab in MCC patients who are anti-PD-1 or anti-PD-L1 treatment naïve. Inhibition of MDM2 is a novel mechanism of action in MCC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Norton Healthcare, Louisville, Kentucky
Conditions: Merkel Cell Carcinoma
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MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
NCT02075775
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
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CERENOVUS Neurothrombectomy Devices Registry
NCT05591183
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Norton Neurology Institute, Elizabethtown, Kentucky
Conditions: Cerebral Stroke
Register for Updates