Kentucky is currently home to 1029 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study
NCT05863351
Recruiting
This phase III trial compares the effect of stero-ablative radiotherapy (SAbR) followed by standard of care systemic therapy, to standard of care systemic therapy alone, in patients with kidney cancer that has spread from where it first started (primary site) to a limited (2-5) number of places in the body (metastatic). Study doctors want to find out if this approach is better or worse than the usual approach for metastatic kidney cancer. The usual approach is defined as the care most people get... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
Conditions: Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
Register for Updates
Harm Reduction for Smokers With Mental Illness
NCT06543407
Recruiting
To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation treatment, and to examine self-regulation (using e-cigs instead of cigarettes to cope with stress/distress and self-efficacy) as a potential mechanism for behavior change from SWITCH IT
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/15/2024
Locations: Seven Counties Services, Louisville, Kentucky
Conditions: Tobacco Dependence
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Lumbar Fusion With Porous Versus Non-Porous Cages
NCT05583864
Recruiting
The objective of this single site, randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo lumbar interbody fusion procedures (TLIF), supplemented with pedicle screw instrumentation, using one of the following interventions: 1. Porous titanium cages 2. Non-porous titanium-coated poly-ether-ether-ketone (PEEK) cages.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/14/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Spinal Fusion, Lumbar Fusion, Arthrodesis, Spondylolisthesis, Pseudarthrosis
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Perform Humeral System Study
NCT05067543
Recruiting
This study is an international, single arm, multicenter, prospective, non-significant risk, Post-Market Clinical Follow-up study, which is designed to collect safety and performance data at baseline, surgery, immediate post-op and annually through 10 years post-operation. Data collected from this study will be used for purposes, including but not limited to, Post-Market Surveillance, peer-reviewed publications, education materials, regulatory submissions, and/or product development.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: Baptist Healthcare, Lexington, Kentucky
Conditions: Osteoarthritis Shoulder, Avascular Necrosis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Tear Arthropathy
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Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
NCT04600089
Recruiting
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/14/2024
Locations: University of Kentucky Medical Center, Lexington, Kentucky
Conditions: Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm
Register for Updates
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
NCT05021835
Recruiting
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Z... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/12/2024
Locations: Lexington VA Health Care System, Lexington, Kentucky
Conditions: Cardiovascular Risk, Chronic Kidney Disease, Inflammation
Register for Updates
Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX)
NCT05838248
Recruiting
This prospective trial will randomize patients who have had an appendectomy to two different durations of antibiotic therapy depending on the status of the appendicitis. For simple appendicitis, patients will be randomized to peri-operative antibiotics or 24 hours duration. For complex appendicitis, patients will be randomized to 24 hours or 4 days duration. Data will be collected prospectively and test the hypothesis that shorter durations of antibiotics will be non-inferior to the longer durat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Jewish Hospital UL, Louisville, Kentucky
Conditions: Appendicitis
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Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
NCT03970343
Recruiting
The OPTIMIZER Smart Post-Approval Study is a prospective, multi-center, non-randomized, single arm open label study of 620 subjects receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: Baptist Lexington, Lexington, Kentucky
Conditions: Heart Failure
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CSTOP Now! Child Sex Trafficking Stops with You
NCT05722769
Recruiting
Focus: Intervention \& prevention of child commercial sexual exploitation or trafficking (CST) In Kentucky, familial SU/D increases risk of CST. Primary goal: Implement and evaluate effectiveness of multi-level bystander-informed program (CSTOP Now!) aimed at Kentucky public middle schools for staff.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
10/08/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Child Sex Trafficking
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Degenerative Cervical Myelopathy Repository
NCT05446259
Recruiting
To create a research repository of patients with known degenerative cervical myelopathy (DCM) and a control cohort of subjects who have non-myelopathic spinal disease. This repository will be used to assess functional and/or biological measures that may allow for improved prediction of symptomatic progression and response to treatment in patients with DCM. In addition, this repository will be used to develop a risk assessment scale to accurately predict functional outcomes following operative ma... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
10/08/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Cervical Myelopathy
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Spinal Cord Injury Neuroprotection With Glyburide
NCT05426681
Recruiting
To assess the safety and efficacy of using oral Glyburide (Diabeta) as a neuroprotective agent in patients with acute cervical or thoracic traumatic spinal cord injury.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/08/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Acute Spinal Cord Injury
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Thoracic-Lumbar Arthrodesis- Implanet Jazz
NCT05366140
Recruiting
Establish a data repository of patients who have undergone single, two-, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
10/08/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Spondylolisthesis, Spinal Stenosis, Degenerative Disease
Register for Updates