Kentucky is currently home to 1068 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Intramedullary Calcium Sulfate Antibiotic Depot
NCT05766670
Recruiting
The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients with a calcium sulfate antibiotic depot is better at preventing infection that the standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Open tíbia Fracture, Osteomyelitis Tibia, Tibial Fractures
Register for Updates
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End Stage Renal Disease
NCT04671771
Recruiting
The goal of the CSP-2002 clinical trial is to evaluate the safety and effectiveness of the InnAVasc Arteriovenous Graft (IG) for hemodialysis (HD) access in patients with end-stage renal disease (ESRD). The primary study endpoints are: Primary Effectiveness Endpoint: The proportion of subjects with secondary patency at 6 months. Primary Safety Endpoint: The incidence of device-related adverse events of special interest (AESIs) through 6 months. Participants will be asked to sign an informed c... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
02/19/2025
Locations: University of Louisville, Louisville, Kentucky
Conditions: End Stage Renal Disease (ESRD), Kidney Failure, Chronic Renal Disease, Hemodialysis
Register for Updates
Brain, Blood and Clot or Tissue Registry and Collaboration
NCT03153683
Recruiting
This is a prospective open enrollment biorepository to collect and evaluate blood and tissue collected during cerebrovascular procedures, which will then be used for the purposes of identifying biological markers, inflammatory cell infiltrates, and biological states in stroke and other cerebrovascular diseases in the human condition. The study population will include up to 1000 subjects with cerebrovascular disease or suspected cerebrovascular disease. Male and female participants 18 years of a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2025
Locations: University of Kentucky Deparment of Neurosurgery, UK Chandler Hospital, Lexington, Kentucky
Conditions: Acute Ischemic Stroke, Cerebrovascular Disorders
Register for Updates
Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer
NCT05659381
Recruiting
Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy (Paclitaxel 175 mg/m2 IV over 3 hours and Carboplatin AUC 6 IV on Day 1 every 21 days for 3-4 cycles). Registered patients who progress during neoadjuvant chemotherapy will not be eligible for iCRS and will be removed from the study. Following completion of neoadjuvant chemotherapy, interval cytoreductive surgery (iCRS) will be performed in the usual fashion in both arms. Patients will be randomized at... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: University of Kentucky Medical Center, Lexington, Kentucky
Conditions: Stage III Ovarian Cancer, Stage IV Ovarian Cancer, Stage III Primary Peritoneal Cancer, Stage IV Primary Peritoneal Cancer, Stage III Fallopian Tube Cancer, Stage IV Fallopian Tube Cancer
Register for Updates
Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer
NCT04990921
Recruiting
This is a phase 2, open-label, single-arm trial designed to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in combination with pembrolizumab following disease progression after two prior lines of standard therapy in unresectable metastatic stage IV breast cancer
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: James Graham Brown Cancer Center, Louisville, Kentucky
Conditions: Metastatic Breast Cancer
Register for Updates
Exploratory Study on the Timing of Multiple Sclerosis (MS) Symptoms
NCT00919217
Recruiting
The investigators' overall hypothesis is that appearance or worsening of relapsing-remitting multiple sclerosis (RR-MS) symptoms are affected by various factors including stress, hormonal cycles, illness and missed medications.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
02/18/2025
Locations: University of Louisville (recruiting nationwide), Louisville, Kentucky
Conditions: Relapsing Remitting Multiple Sclerosis
Register for Updates
Vaginal Baclofen Suppositories in Chronic Pelvic Pain
NCT05968937
Recruiting
The purpose of this study is to evaluate if baclofen vaginal suppositories improve symptoms of Chronic Pelvic Pain (CPP). Participants in this study will take four short questionnaires prior to being randomized. Randomization is like flipping a coin; participants have an equal likelihood of being randomized to the treatment group (vaginal baclofen suppositories) or placebo group (vaginal suppository without baclofen ingredient). Participants will take their assigned treatment nightly for 8 week... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
02/17/2025
Locations: ULP Female Pelvic Medicine and Reconstructive Surgery - Springs Medical Center Suite 190, Louisville, Kentucky
Conditions: Chronic Pelvic Pain Syndrome
Register for Updates
Impaired Risk Awareness During Intoxication in DUI Offenders
NCT05247788
Recruiting
This study aims to test the efficacy of experiential-based training to increase DUI offenders' perceptions or risk associated with alcohol use.
Gender:
FEMALE
Ages:
Between 21 years and 45 years
Trial Updated:
02/17/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Alcohol Use
Register for Updates
Comparison Using a VLS Using GlideRite Stylet Versus TCI Articulating Introducer in Predictive Difficult Intubation
NCT04866472
Recruiting
This study will assess the feasibility of using the TCI Articulating Device with video-laryngoscope in predictive, difficult airway, endotracheal intubation cases. It is meant to show the use of this device is equivalent to using the GlideRite Rigid Stylet with video-laryngoscope.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/17/2025
Locations: University of Louisville School of Medicine, Louisville, Kentucky
Conditions: Predicted Difficult Airway
Register for Updates
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)
NCT06116682
Recruiting
This phase II Expanded Lung-MAP treatment trial tests how well amivantamab-subcutaneous (SC) works in treating patients patients with MET amplification non-small cell lung cancer. Amivantamab-SC is a drug that reduces extra copies of the MET gene, a change present in your tumor. Giving amivantamab-SC may lower the chance of the growth or spread of advanced non-small cell lung cancer that has extra copies of the MET gene in the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2025
Locations: University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Conditions: Lung Non-Small Cell Carcinoma
Register for Updates
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
NCT06031688
Recruiting
This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (stage IV) or that has come back after a period of improvement (recurrent). Tepotinib is used in patients whose cancer has a mutated (changed) form of a gene called MET. It is in a class of medications called kinase inhibitors. It works by blocking t... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/14/2025
Locations: University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Register for Updates
Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation
NCT03663361
Recruiting
The purpose of this project is to compare a novel sensorimotor ankle rehabilitation training (SMART) protocol for Lateral ankle sprains (LASs) against a standard of care (SOC) protocol to determine if it is more successful at producing successful one-year outcomes and lower rates of re-injury and improved health. This will address the identified needs for evidence-support and reintegration strategies to improve understanding of the management of patient rehabilitation strategies throughout the r... Read More
Gender:
ALL
Ages:
Between 18 years and 44 years
Trial Updated:
02/10/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Ankle Sprains
Register for Updates