Kentucky is currently home to 1026 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
NCT01656603
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: James Graham Brown Cancer Center, Louisville, Kentucky
Conditions: Infusion Reactions
Register for Updates
A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia
NCT05172752
Recruiting
Appalachian Kentuckians in Martin and Letcher Counties are grappling with a health-threatening drinking water crisis arising from exposures to disinfection by-products (DBPs). DBPs include trihalomethanes (THMs), haloacetic acids (HAAs), chlorate, and other compounds that have been associated with a variety of adverse health effects, including increased risk of bladder cancer and cardiovascular birth defects. This study implements a multi-stakeholder, multi-method approach to improve understandi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Disinfection By-products
Register for Updates
Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)
NCT04816604
Recruiting
This open-label extension study will evaluate the long-term effects of GB002 (seralutinib) in subjects who previously participated in a GB002 PAH study.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/16/2024
Locations: Norton Pulmonary Specialists, Louisville, Kentucky
Conditions: Pulmonary Arterial Hypertension
Register for Updates
Pinhole Versus Tunnel for Soft Tissue Recession
NCT04513041
Recruiting
This is an assessor-blinded split-mouth randomized clinical study to compare root coverage and gingival tissue thickness following two different surgical procedures for non-autologous grafting: the pinhole surgical technique (PST) and tunnel technique.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/16/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Gingival Recession
Register for Updates
Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative
NCT05565079
Recruiting
24 patients will be treated with a coronally positioned tunnel with AlloDerm RTM with or without the addition of Enamel Matrix Derivative to compare the baseline and 6-month changes in recession defect coverage, clinical attachment levels, amount of keratinized tissue width, and soft tissue thickness.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Recession, Gingival
Register for Updates
Alveolar Ridge Preservation With Putty Allograft vs. Putty Alloplast Graft
NCT05484492
Recruiting
The primary aims of this study are to compare, after 4 months, the clinical and histologic results of a combination demineralized/mineralized putty allograft vs. synthetic calcium phosphosilicate (CPS) putty alloplast graft utilization in socket preservation procedures. A regenerative tissue matrix membrane will be used to cover each graft lying below the flap.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Alveolar Bone Resorption
Register for Updates
Quality of Pediatric Resuscitation in a Multicenter Collaborative
NCT02708134
Recruiting
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
04/12/2024
Locations: Kentucky Children's Hospital, Lexington, Kentucky
Conditions: Cardiac Arrest, Cardiopulmonary Arrest
Register for Updates
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer
NCT03418961
Recruiting
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Flaget Memorial Hospital, Bardstown, Kentucky
Conditions: Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7
Register for Updates
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
NCT00736749
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
Gender:
ALL
Ages:
All
Trial Updated:
04/10/2024
Locations: University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
Register for Updates
Prospective Evaluation of Pathways for Preterm Birth
NCT05246579
Recruiting
This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients without a short cervix will be recruited to provide baseline data. Plan to enroll 240 patients identified through our ultrasound unit with goal of 60 patients in each group.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/09/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Preterm Birth, Cervix; Pregnancy
Register for Updates
Guided Bone Regeneration With and Without the Use of Intra-marrow Penetrations
NCT06353399
Recruiting
The primary aims of this study are to compare, after 6 months, the clinical and histologic results of intra-marrow penetrations vs no intra-marrow penetrations when performing guided bone regeneration procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Ridge Augmentation
Register for Updates
PDA Occlusion Using NIRS
NCT06359522
Recruiting
Our study will be a prospective observational study of all patients in the Norton Children's Hospital NICU (Neonatal Intensive Care Unit) who undergo a transcatheter PDA occlusion or medical closure of PDA to compare the two populations regarding changes in organ perfusion determined by using NIRS monitoring to follow the regional saturation of oxygen (rSO2) of the cerebral and renal regions. We suspect that medical treatment will have no significant change in rSO2 as described in previous liter... Read More
Gender:
ALL
Ages:
Between 0 months and 3 months
Trial Updated:
04/05/2024
Locations: Norton Children's Hospital, Louisville, Kentucky
Conditions: Organ Perfusion Determined by Using NIRS Post Transcatheter PDA Occlusion or Medical Closure of PDA
Register for Updates