Kentucky is currently home to 1068 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
NCT04032990
Recruiting
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles. The purpose of this project is to test the safety, comfort, and practicality of a new therapy that stimulates the spinal cord to facilitate activation of arm and hand muscles while practicing grasping, pinching, and reaching movements. The long-term goal is to provide better therapies that will improve the ability of children with SCI to m... Read More
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
06/20/2024
Locations: Department of Neurosurgery, Louisville, Kentucky
Conditions: Spinal Cord Injuries
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Evaluation of a Monofocal Intraocular Lens
NCT06428955
Recruiting
The aim of this study is to investigate the 3-month visual performance of the CT LUCIA 621P IOL, a hydrophobic aspheric monofocal IOL with a non-constant aspheric optic profile in adult patients 50 years of age or older who are undergoing cataract surgery.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/19/2024
Locations: Huffman & Huffman PSC, Lexington, Kentucky
Conditions: Cataract
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Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)
NCT06095583
Recruiting
The Study is a Phase 3, randomized, three-arm, double-blind, placebo-controlled, multi-regional clinical research study to evaluate the safety and efficacy use of toripalimab alone or in combination with tifcemalimab as consolidation therapy in patients with limited-stage small cell lung cancer without disease progression following chemoradiotherapy. Tifcemalimab is a monoclonal antibody against B and T lymphocyte attenuator (BTLA). Toripalimab is a monoclonal antibody against programmed death... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2024
Locations: Norton Cancer Institute, Downtown, Multidisciplinary Clinic, Louisville, Kentucky
Conditions: Limited-stage Small Cell Lung Cancer (LS-SCLC)
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A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT02817633
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2024
Locations: GSK Investigational Site, Louisville, Kentucky
Conditions: Neoplasms
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The Effect of Omega-3 Fortified Smoothies on Omega-3 Index and Physical Performance Related Outcomes Among Soldiers
NCT06462898
Recruiting
The goal of this clinical trial is to test the effect of omega-3 on physical performance and recovery of Soldiers. Objectives 1: Assess the impact of 8-weeks of daily consumption of 1600mg of omega-3 fortified smoothie on O3I response. Objective 2: Determine the relationship between O3I and measures of performance and recovery. Participants will: * Be randomly assigned to placebo group or to the omega-3 fortified smoothie group. * The intervention group will take omega-3 fortified smoothies... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
06/14/2024
Locations: Fort Campbell, Fort Campbell North, Kentucky
Conditions: Nutrition, Healthy
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Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair
NCT03610763
Recruiting
This study adopts a strategy that has arisen from basic neuroscience research on facilitating adaptive brain plasticity and applies this to rehabilitation to improve functional recovery in peripheral nervous system injuries (including hand transplantation, hand replantation, and surgically repaired upper extremity nerve injuries). The technique involves combining behavioral training with transcranial direct current stimulation (tDCS)-a non-invasive form of brain stimulation capable of facilitati... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: Christine Kleinert Institute for Hand & Microsurgery, Louisville, Kentucky
Conditions: Hand Transplantation, Peripheral Nerve Injuries, Neurologic Rehabilitation
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Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Register for Updates
Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma
NCT04513028
Recruiting
The purpose of this study is to determine how beta-glucan affects the immune system in subjects with melanoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Melanoma Stage III, Melanoma Stage IV
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Intramedullary Bone Grafting for Open Tibial Shaft Fractures
NCT03891888
Recruiting
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia. Both groups will undergo primary fixation via reamed intramedulary nailing (IMN), a common treatment for tibia shaft fractures in adults. The study group will have a bone graft applied to the open cortex of the fracture. The bone graft will be composed of the intramedullary reamings, whic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
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Study of DF9001 in Patients With Advanced Solid Tumors
NCT05597839
Recruiting
DF9001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express epidermal growth factor receptor (EGFR). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Solid Tumor, Adult
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Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies
NCT05548413
Recruiting
People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them work together and build skills to overcome their individual barriers to adherence in order to 1) improve and sustain patient medication adherence; 2) reduce hospitalization; 3) improve quality of life. I... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: Jia-Rong Wu, Lexington, Kentucky
Conditions: Medication Adherence, Heart Failure
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Resistance Training in Type 1 Diabetes Mellitus
NCT05315037
Recruiting
The purpose of this study is to learn how different resistance training programs affects blood sugar in young athletes with T1DM.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
05/09/2024
Locations: Norton Healthcare, Louisville, Kentucky
Conditions: Type 1 Diabetes
Register for Updates