There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Multicenter Interventional Lymphangioleiomyomatosis (LAM) Early Disease Trial
NCT03150914
Recruiting
This is a study to determine if early, long-term low dose sirolimus is effective for preventing progression to more advanced stages.
Gender:
Female
Ages:
18 years and above
Trial Updated:
10/25/2023
Locations: Brigham and Woman's Hospital, Boston, Massachusetts
Conditions: LAM, Lymphangioleiomyomatosis
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MED3000 Topical Gel for On-Demand Treatment of Post-Radical Prostatectomy Erectile Dysfunction
NCT05673005
Recruiting
The investigators are doing this research to evaluate the efficacy and safety of topical MED3000 therapy in men with persistent erectile dysfunction 1.5 to 4 years following radical prostatectomy surgery.
Gender:
All
Ages:
Between 40 years and 70 years
Trial Updated:
10/25/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Erectile Dysfunction Following Radical Prostatectomy
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A Phase II Evaluation of Afatinibin Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma
NCT02491099
Recruiting
Primary Objective: To assess the activity of Afatinib in patients with persistent or recurrent uterine serous carcinoma overexpressing HER2/neu with the frequency of patients who survive progression-free for at least 6 months after initiating therapy. Secondary Objectives: To assess objective response rate and durable disease control rate. To assess overall survival. To assess the safety profile of Afatinib in uterine serous carcinoma patients.
Gender:
Female
Ages:
Between 18 years and 100 years
Trial Updated:
10/25/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: HER2/Neu+ Uterine Serous Carcinoma
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Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
NCT05103566
Recruiting
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage (SAH) subjects in a neurocritical care setting. 25 patients will be enrolled, all treated with an active device. The primary efficacy outcomes are reduced aneurysm rupture rate, reduced seizure and seizure-spectrum activity, minimized hemorrhage grades, and increased survi... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/24/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Subarachnoid Hemorrhage, Aneurysmal
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Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
NCT05216770
Recruiting
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Massachusetts Eye and Ear and University of California San Francisco, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
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Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
NCT05150106
Recruiting
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Massachusetts Eye and Ear and University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
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Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
NCT05150093
Recruiting
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Massachusetts General Hospital, University of California San Francisco, University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
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Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial
NCT02000115
Recruiting
The objective of the PORTICO pivotal IDE trial is to evaluate the safety and effectiveness of the St Jude Medical (SJM) Portico Transcatheter Heart Valve and Delivery Systems (Portico) in the treatment of severe symptomatic aortic stenosis via transfemoral and alternative delivery methods in high risk and extreme risk patients.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/24/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Aortic Valve Stenosis
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Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)
NCT04997902
Recruiting
This phase 1/2 combination trial of tipifarnib, a farnesyltransferase inhibitor, and alpelisib, a PI3K inhibitor in participants with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) whose tumors overexpress the HRAS protein and/or are PIK3CA-mutated and/or PIK3CA-amplified.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/24/2023
Locations: Dana-Farber Cancer Institute (Head and Neck Cancer Treatment Center), Boston, Massachusetts
Conditions: HNSCC
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Beacon Sensors and Telerehabilitation to Assess and Improve Use of Devices (BeST-AID) for Low Vision
NCT06107881
Recruiting
One goal of this research is to conduct a non-inferiority trial of telerehabilitation versus in-office care to provide follow-up training to individuals with low vision to enhance their quality of life by using magnification devices and/or visual assistive mobile apps for important daily activities, such as reading and/or other valued tasks. This is a high priority given the increasing prevalence of low vision, paucity of low vision rehabilitation providers, and barriers related to access to car... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/24/2023
Locations: New England College of Optometry, Boston, Massachusetts
Conditions: Low Vision, Low Vision Aids
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Imaging Genetics of Laryngeal Dystonia
NCT03042975
Recruiting
The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different phenotypes of dystonia (e.g., familial, sporadic) remains limited. The research program of the investigators is set to determine the relationship between brain changes and genetic risk factors in laryngeal dystonia (or spasmodic dysphonia). The researchers use a novel approach of... Read More
Gender:
All
Ages:
All
Trial Updated:
10/24/2023
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Unaffected Relatives of Laryngeal Dystonia Patients, Voice Tremor, Muscle Tension Dysphonia
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Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
NCT05172024
Recruiting
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals who will enter the cohort with and without SARS-CoV-2 infection and at varying stages before and after infection. Individuals with and without SARS-CoV-2 infection and with or without Post-Acute Sequelae of COVID-19 (PASC) symptoms will be followed to identify risk factors and occurrence of PASC. This study will be conducted in the United States and subjects will be recruited through inpatien... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/24/2023
Locations: Tufts Medical Center, Boston, Massachusetts +7 locations
Conditions: SARS-CoV2 Infection
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