There are currently 2701 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
NCT04875702
Recruiting
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered gout outcomes, as well as relevant cardiovascular-metabolic-renal endpoints.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Gout
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Lung Recruitment Maneuver As a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
NCT03431064
Recruiting
In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration. It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.
Gender:
ALL
Ages:
17 years and below
Trial Updated:
09/26/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Anesthesia, Intravenous Fluid, Blood Pressure
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Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
NCT06094257
Recruiting
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and connecting them to the nipple and areola. The investigators aim to compare postoperative sensation and patient reported outcomes in patients undergoing reinnervation versus those not undergoing reinnervation to determine if there is a difference. The investigators will inves... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic, Numbness, Sensory Disorder, Sensory Defect, Phantom Pain, Phantom Sensation
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Olorofim Aspergillus Infection Study
NCT05101187
Recruiting
The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus species (invasive aspergillosis, IA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Invasive Aspergillosis
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Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
NCT04124029
Recruiting
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after brain injury and in dementia.
Gender:
ALL
Ages:
Between 30 years and 90 years
Trial Updated:
09/25/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
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STOP-HER2: Stopping Trastuzumab in HER2+ MBC
NCT05721248
Recruiting
This study is being done to see if anti-HER2 treatment be safely stopped in patients with HER2-positive metastatic breast cancer (MBC) that have had exceptional response to treatment. Exceptional response" is considered as cancer progression being controlled for three years or more since starting anti-HER2 treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Dana-Farber Cancer Insitute, Boston, Massachusetts
Conditions: Breast Cancer, Metastatic Breast Cancer, HER2-positive Breast Cancer
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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
NCT03827694
Recruiting
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
Gender:
ALL
Ages:
Between 120 days and 21 years
Trial Updated:
09/24/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pulmonary Invasive Aspergillosis, Pulmonary Invasive Fungal Infections
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Gamma-Induction in FrontoTemporal Dementia Trial
NCT04425148
Recruiting
This is an interventional, sham controlled, double-blind study designed to investigate the safety, tolerability and efficacy of 40 Hz transcranial alternating current stimulation (tACS), a form of noninvasive brain stimulation, delivered for 6 weeks once daily in frontotemporal dementia (FTD) patients. Cognition, gamma EEG activity and brain metabolism via FDG-PET will be measured before and after the tACS intervention.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
09/24/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Frontotemporal Dementia
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A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
NCT06056635
Recruiting
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery. A fetoscope is like a small telescope that can see inside of the uterus (womb) during minimally invasive surgery. The curved scope is used for patients with an anterior placenta (front of uterus), while the straight scope is used for patients with a posterior placenta (back of uterus). The scopes will be used to assist... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
09/24/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome, In Utero Procedure Affecting Fetus or Newborn, Chorion; Abnormal, Twin Reversal Arterial Perfusion Syndrome, Twin Monochorionic Monoamniotic Placenta, Chorioangioma, Vasa Previa
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Modulating Exercise Dosage to Improve Concussion Recovery
NCT05434130
Recruiting
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity l... Read More
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
09/24/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Concussion, Brain, Treatment, Aerobic Exercise, Inflammation, Depression, Anxiety
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Trastuzumab Deruxtecan Alone or in Combination with Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
NCT04553770
Recruiting
This phase II trial investigates how well trastuzumab deruxtecan works alone or in combination with anastrozole in treating patients with HER2 low, hormone receptor positive breast cancer. Trastuzumab deruxtecan is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug called deruxtecan. Trastuzumab attaches to HER2 expressed at low levels on cancer cells in a targeted way and delivers deruxtecan to kill them. Anastrozole works by decreasing estrogen production and suppressing... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/23/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Early-stage Breast Cancer, Hormone Receptor Positive Breast Carcinoma, Invasive Breast Cancer, Stage II Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage III Breast Cancer
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Allogeneic Valve Transplantation
NCT06387446
Recruiting
Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve.
Gender:
ALL
Ages:
Between 30 days and 50 years
Trial Updated:
09/22/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Valve Heart Disease, Valve Disease, Heart, Valve Disease, Aortic
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