There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
NCT05103566
Recruiting
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage (SAH) subjects in a neurocritical care setting. 25 patients will be enrolled, all treated with an active device. The primary efficacy outcomes are reduced aneurysm rupture rate, reduced seizure and seizure-spectrum activity, minimized hemorrhage grades, and increased survi... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/24/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Subarachnoid Hemorrhage, Aneurysmal
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Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
NCT05216770
Recruiting
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Massachusetts Eye and Ear and University of California San Francisco, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
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Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
NCT05150106
Recruiting
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Massachusetts Eye and Ear and University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
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Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
NCT05150093
Recruiting
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Massachusetts General Hospital, University of California San Francisco, University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
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Triage Survey for Neurology Research Eligibility
NCT06104852
Recruiting
TRIAGE-Neuro is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored neurology clinical trials.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Copley Clinical, Boston, Massachusetts
Conditions: Alzheimer Disease
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A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
NCT05899361
Recruiting
This research study is a pilot clinical trial, which hypothesizes that the combination of electromagnetic tracking in conjunction with laparoscope imaging and ultrasound probe imaging will aid in reducing the complexity of both laparoscopic lymphadenectomy and/or organ removal in patients with a confirmed diagnosis of cancer in urologic regions of interest (Bladder, Prostate, Testicular, Kidney, Urethral, and Penis), by resulting in better visualization and more accurate localization of certain... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Urologic Cancer, Urologic Neoplasms, Bladder Cancer, Prostate Cancer, Testicular Cancer, Kidney Cancer, Urethral Cancer, Penile Cancer
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A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseases
NCT04554914
Recruiting
The purpose of this study is to assess the efficacy and safety of tabelecleucel in participants with Epstein-Barr virus (EBV) associated diseases.
Gender:
All
Ages:
All
Trial Updated:
10/23/2023
Locations: Dana Farber Cancer Institute (DFCI) (Adults and Pediatrics), Boston, Massachusetts
Conditions: Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications, EBV+ Sarcomas, Leiomyosarcoma, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
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A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma
NCT05651932
Recruiting
A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Multiple Myeloma, Myeloma, Myeloma Multiple
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Mucolipidosis Type IV Natural History Study
NCT05782387
Recruiting
The primary objectives of the study are: to describe the characteristics of the current international MLIV population; to define the median age at which patients with MLIV achieve or lose developmental milestones; to define the natural history of MLIV for the Gross Motor Function Classification System (GMFCS) (Morris and Bartlett, 2004) and the MLIV specific scale and test the validity of retrospectively applying these scales to medical record data; to define the rate of visual decline in patien... Read More
Gender:
All
Ages:
All
Trial Updated:
10/23/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Mucolipidosis Type IV
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Urologic Lymphadenectomy in AMIGO
NCT05132283
Recruiting
This research study involves the use of two navigation systems, the 3D Slicer-based navigation system, and the Siemens Monaco systems, to simplify the complexity of image-guided lymphadenectomy procedures (surgery to remove one or more lymph nodes) in patients with urological cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Urologic Cancer, Lymph Node Metastasis
Register for Updates
Insomnia Prevention in Children With Acute Lymphoblastic Leukemia
NCT05866887
Recruiting
The goal of this research study is to understand the acceptability and feasibility of the Sleep ALL Night intervention among children with Acute Lymphoblastic Leukemia (ALL) in hopes of improving the discussion of sleep disorders with clinical providers. The name of the intervention used in this research study is: Sleep ALL Night, which is a sleep intervention program comprised of an action plan tool and psychoeducational website.
Gender:
All
Ages:
Between 4 years and 12 years
Trial Updated:
10/23/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Pediatric Acute Lymphoblastic Leukemia, Leukemia, Acute Lymphoblastic Leukemia
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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
NCT04910685
Recruiting
This is a randomized, double-blind, placebo-controlled, Phase 2/3 study comparing the efficacy and safety of BLU-263 + best supportive care (BSC) with placebo + BSC in patients with indolent systemic mastocytosis (ISM) whose symptoms are not adequately controlled by BSC. Parts 1 and 2 will enroll patients with ISM. Patients enrolled in Part 1 or Part 2 will roll over onto Part 3 to receive treatment with BLU-263 in an open-label fashion following completion of the earlier Part. Part M will enrol... Read More
Gender:
All
Ages:
16 years and above
Trial Updated:
10/20/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Indolent Systemic Mastocytosis, Monoclonal Mast Cell Activation Syndrome
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