There are currently 2699 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support
NCT03593408
Recruiting
This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these drugs in this setting.
Gender:
ALL
Ages:
Between 0 days and 17 years
Trial Updated:
11/12/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Drug Effect
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Study in Parkinson Disease of Exercise
NCT04284436
Recruiting
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 mon... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/12/2024
Locations: Boston University (Charles River Campus), Boston, Massachusetts
Conditions: Parkinson Disease
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Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
NCT05379985
Recruiting
Evaluate the safety and tolerability of RMC-6236 in adults with specific RAS mutant advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors
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Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
NCT06426628
Recruiting
The goal of this observational study is to learn how a physician uses the results of the Percepta® Nasal Swab test to manage people with a newly identified pulmonary nodule. The main questions it aims to answer are: * Does the use of the Percepta Nasal swab test reduce the number of invasive procedures in people with a low-risk result and whose nodule is benign? * Does the use of the Percepta Nasal swab test decrease the time to treatment in people with a high-risk result and whose nodule is c... Read More
Gender:
ALL
Ages:
Between 29 years and 85 years
Trial Updated:
11/12/2024
Locations: Boston University Medical Center, Boston, Massachusetts
Conditions: Pulmonary Nodule, Solitary, Lung Cancer
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Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM
NCT04653246
Recruiting
This research is testing whether the investigational drug isatuximab is safe and effective when used in combination with standard agents for the treatment of newly diagnosed multiple myeloma.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
11/08/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Multiple Myeloma, Newly Diagnosed Multiple Myeloma (NDMM), Autologous Stem Cell Transplant
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Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
NCT04199000
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Disorders of Glycosylation
Register for Updates
Improving Memory in Alzheimer's Disease with Noninvasive Brain Stimulation
NCT06094192
Recruiting
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
11/06/2024
Locations: 677 Beacon St. Room 308, Boston, Massachusetts
Conditions: Alzheimer Disease
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Real-world Patient Reported Outcomes Among Patients Treated With Camzyos
NCT06551129
Recruiting
This real-world study will assess changes in health status among participants with symptomatic obstructive hypertrophic cardiomyopathy who are treated with mavacamten in the real world.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Analysis Group Inc., Boston, Massachusetts
Conditions: Obstructive Hypertrophic Cardiomyopathy
Register for Updates
Pancreatic Cancer Screening for At-risk Individuals
NCT05006131
Recruiting
The investigators' goal is to conduct a prospective multicenter study to evaluate the yield and outcomes of screening of pancreas cancer in individuals who are at-risk for pancreatic cancer. We plan to use International Cancer of the Pancreas Screening (CAPS3) Consortium recommendations to standardize study population, screening methodology, and study outcomes.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Pancreatic Cancer, Adult
Register for Updates
Improving Hallucinations by Targeting the RSTS with TES
NCT05165654
Recruiting
Hallucinations are a core diagnostic feature of psychotic disorders. They involve different sensory modalities, including auditory, visual, olfactory, tactile, and gustatory hallucinations, among others. Hallucinations occur in multiple different neurological and psychiatric illnesses and can be refractory to existing treatments. Auditory hallucinations and visual hallucinations are found across diagnostic categories of psychotic disorders (schizophrenia, schizoaffective, bipolar disorder). Desp... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Hallucinations, Auditory, Psychosis
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Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer
NCT06038318
Recruiting
The goal of this study is to find the best way to help participants and families manage the stress of facing a serious illness and be better able to "bounce back" or be resilient after a difficult situation. Participants will take part in the "Promoting Resilience in Stress Management" PRISM program, which is designed to provide skills to change or improve the impact of stress in everyday life. The name of the intervention used in this research study is: -PRISM (a mobile app program comprised... Read More
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
11/05/2024
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Stress, Anxiety
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A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
NCT06115746
Recruiting
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300 middle and high school students, who have violated their school substance use policies in the past month, as an alternative to punitive school responses for school-based substance use infractions. This randomized controlled trial will test the hypothesis that adolescents rand... Read More
Gender:
ALL
Ages:
Between 9 years and 22 years
Trial Updated:
11/05/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Substance Use, Harm Reduction, Adolescent Behavior
Register for Updates