Ohio is currently home to 3201 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
NCT05476770
Recruiting
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is pre... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
12/04/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Hematologic Malignancy, AML, ALL, BPDCN, MDS, Lymphoblastic Lymphoma, Lymphoma, B-Cell, Lymphoma, T-Cell, Hodgkin Lymphoma, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
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A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
NCT05361174
Recruiting
This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/04/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Unresectable Melanoma, Metastatic Melanoma, Stage III Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
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Linking Somatic Mutation Rate With Baseline Exposure in East Palestine
NCT06357845
Recruiting
The goal of this study is to This research team is conducting this study to develop methods to measure the biological impact of exposure to the chemicals released following the February 3, 2023 train derailment on residents of East Palestine, Ohio, and surrounding communities. The main question it aims to answer is: * What biological impact will be measured based on DNA damage? * In participants who provide a biospecimen, how are biomarker changes related to proximity to the derailment and vari... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Somatic Mutation
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A Research Study of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma
NCT05910567
Recruiting
Bleeding from intra-abdominal injuries is a leading cause of traumatic deaths in children. Abdominal CT is the reference standard test for diagnosing intra-abdominal injuries. Compelling reasons exist, however, to both aggressively evaluate injured children for intra-abdominal injuries with CT and to limit abdominal CT evaluation to solely those at non-negligible risk. The focused assessment sonography for trauma (FAST) examination can help focus patient evaluation in just this manner by potenti... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
12/03/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Blunt Trauma to Abdomen, Wounds and Injuries, Abdomen Injury, Abdominal Injury, Abdomen, Acute
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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
NCT05710848
Recruiting
This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Non-muscle-invasive Bladder Cancer
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Patient Recall After Orthopedic Trauma
NCT05616312
Recruiting
The purpose of this study is to evaluate whether receiving education after trauma surgeries affects three things: 1) knowledge about injury and treatment ("recall"), 2) how well patients follow treatment recommendations, and 3) how satisfied patients are with their care. To do so, some participants in this study will receive education, and some will not.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/03/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Education After Trauma
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GUARDIAN (NCT04884802) Sub-study, Etomidate vs Propofol
NCT04934683
Recruiting
Some patients participating in the underlying GUARDIAN trial (NCT04884802) will be additionally randomized to etomidate vs propofol for anesthetic induction.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
12/03/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Major Surgery
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Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
NCT06719583
Recruiting
BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Parkinson Disease
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Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic
NCT06226610
Recruiting
The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
12/02/2024
Locations: Akron Children's Hospital, Akron, Ohio
Conditions: Pruritis
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Modernizing Perinatal Syphilis Testing
NCT06082453
Recruiting
Treponema pallidum is a bacterium that causes the disease syphilis. The primary objective of the study is to evaluate the testing performance of two diagnostic molecular techniques \[quantitative polymerase chain reaction (qPCR) and transcription-mediated amplification (TMA)\] for the detection of Treponema pallidum in maternal and neonatal specimens from participants with the diagnosis of syphilis using the Centers for Disease Control's (CDC's) Sexually Transmitted Infections (STI) Treatment Gu... Read More
Gender:
ALL
Ages:
45 years and below
Trial Updated:
12/02/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Syphilis
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Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery
NCT05488054
Recruiting
This study will utilize the Moxy wearable sensor to measure muscle oxygen saturation levels in athletes following lower extremity surgery (ACL or Hip arthroscopy) to evaluate their Return-to-Play. The acquired data will complement current protocols utilized by Dr. Voos and Dr. Salata in this regard and will add quantifiable evidence to enable a robust measurement of the surgical limb versus non-surgical limb.
Gender:
ALL
Ages:
Between 14 years and 30 years
Trial Updated:
12/01/2024
Locations: University Hospitals Physical Therapy, Avon, Ohio
Conditions: ACL Injury, Hip Injuries
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MRI in Transcatheter Aortic Valve Replacement Patients
NCT05603026
Recruiting
The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessment of paravalvular leak and its impact on ventricular function and on clinical outcomes.
Gender:
ALL
Ages:
Between 18 years and 105 years
Trial Updated:
11/29/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Aortic Valve Stenosis
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