There are currently 1184 clinical trials in Pittsburgh, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pittsburgh, University of Pittsburgh Medical Center, Alleghany General Hospital and Children's Hospital of Pittsburgh UPMC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
NCT03295981
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania
Conditions: Giant Cell Tumor of Bone
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Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
NCT02434393
Recruiting
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
10/03/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Major Depression, Late Life Depression (LLD)
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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
NCT05380531
Recruiting
The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: UPMC Magee Women's Hospital, Pittsburgh, Pennsylvania +1 locations
Conditions: Cesarean Section Complications, Opioid Use
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C-TIL051 in Non-Small Cell Lung Cancer
NCT05676749
Recruiting
The goal of this Phase 1 clinical study is test tumor infiltrating lymphocytes (known as C-TIL051) with NKTR-255 and anti-PD1 therapy for subjects with refractory non-small cell lung cancer. The purpose of this study is to: 1. Test the safety and ability for subjects to tolerate the TIL therapy 2. Measure to see how the NSCLC responds to the TIL therapy Participants will be asked to: * Provide a tumor sample prior to the start of any treatment which will be used to make the C-TIL051. * Recei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Allegheny Health Network-West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: Metastatic Non Small Cell Lung Cancer
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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
NCT05926765
Recruiting
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Alleghany General Hospital, Pittsburgh, Pennsylvania
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
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Biomarkers in Transplant Recipients to Improve Outcomes
NCT01163578
Recruiting
The objective of this study is to evaluate whether certain proteins, expressed in biological tissues can indict a better understanding of the effect of drugs that are used to treat rejection, and of processes leading to rejection and rejection-free outcomes.
Gender:
ALL
Ages:
All
Trial Updated:
10/02/2024
Locations: Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Conditions: Solid Organ Transplantation, Bone Marrow Transplantation
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Mapping Disease Pathways for Biliary Atresia
NCT03273049
Recruiting
This project will primarily evaluate the developmental/genetic basis of biliary atresia, the most common cause of liver failure at birth, and which accounts of half of all liver transplants performed worldwide in children.
Gender:
ALL
Ages:
All
Trial Updated:
10/02/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Biliary Atresia
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Molecular and Cellular Characterization of Skull Base Tumors
NCT03759717
Recruiting
The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.
Gender:
ALL
Ages:
All
Trial Updated:
10/02/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Skull Base Neoplasm, Cellular Pathology
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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: AHN West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: HER2-positive Advanced Solid Tumor
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Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)
NCT05367609
Recruiting
The purpose of this collaborative CTSA application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in children undergoing painful surgery.
Gender:
ALL
Ages:
Between 10 years and 21 years
Trial Updated:
10/01/2024
Locations: UPMC Children's Hospital, Pittsburgh, Pennsylvania
Conditions: PPAP, Spine Fusion
Register for Updates
Development and Testing of ImHere4U: a Digital Suicide Prevention Intervention for Cyberbullied Adolescents
NCT06002191
Recruiting
The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents. The specific aims are to: Aim #1: Conduct a randomized controlled trial (RCT) comparing Flourish+Questionnaires vs. Questionnaires Alone among cyberbullied youth at-risk for suicide ages 12-17 (N=80, \>35% underserved youth). H2a. Primary outcome: Feasibility will be evidenced by recruitment/rete... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
10/01/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Psychological Distress, Suicidal Ideation
Register for Updates