Rhode Island is currently home to 495 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Providence, Warwick, East Providence and Johnston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
NCT06605378
Recruiting
This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.
Gender:
ALL
Ages:
All
Trial Updated:
02/07/2025
Locations: Home-based telemedicine, Providence, Rhode Island
Conditions: Chronic Granulomatous Disease (CGD)
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Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
NCT06468202
Recruiting
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy (HDP), and that there are multiple factors associated with adherence with aspirin therapy that will be important to identify to enable optimal implementation of study findings and population-level benefits.
Gender:
FEMALE
Ages:
Between 14 years and 35 years
Trial Updated:
02/07/2025
Locations: Brown University, Providence, Rhode Island
Conditions: Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
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Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)
NCT06098079
Recruiting
A randomized, double-blinded, placebo controlled study intended to capture cardiovascular outcomes during real-world use of naltrexone/bupropion (NB).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Velocity Clinical Research (Providence), East Greenwich, Rhode Island
Conditions: Obesity
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MDMA for AUD/PTSD Comorbidity
NCT05943665
Recruiting
The study investigators are conducting the first open label pilot trial of MDMA-assisted therapy (MDMA-AT) with a comorbid sample of military veterans with a comorbid diagnosis of Alcohol Use Disorder (AUD) and Post-Traumatic Stress Disorder (PTSD). This novel experimental treatment package consists of two once-monthly Experimental Sessions of therapy combined with a divided-dose of MDMA HCl, along with non-drug preparatory and integrative therapy. The Primary Outcome measure, the Timeline Follo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Brown University, Providence, Rhode Island
Conditions: Alcohol Use Disorder, Post Traumatic Stress Disorder
Register for Updates
Prolonged Manual Ventilation Simulation
NCT06805838
Recruiting
A pilot study on simulated lung scenarios using the standard manual resuscitator bag, flow limiting resuscitator bag, and an FDA approved flow rate limiting device paired with a standard manual resuscitator.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Brown Physicians, Inc, Providence, Rhode Island
Conditions: Manual Ventilation
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A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients with CtDNA-positive, Resected Stage II (high Risk) and Stage III Colorectal Cancer
NCT04486378
Recruiting
This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulating tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer, or Stage II (high risk)/Stage III colon cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Colorectal Cancer Stage II, Colorectal Cancer Stage III
Register for Updates
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
NCT05180773
Recruiting
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and clinical outcomes. Given that bromocriptine prevents breastfeeding, an additional 50 women with peripartum cardiomyopathy excluded from the trial due to a desire to continue breastfeeding but meeting all other entry criteria will be followed in an observational cohort.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Peripartum Cardiomyopathy, Postpartum
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Cycled Phototherapy
NCT03927833
Recruiting
Cycled phototherapy (PT) is likely to increase survival over that with continuous PT among extremely premature infants (\< 750 g BW or \<27 weeks GA).
Gender:
ALL
Ages:
Between 22 weeks and 27 weeks
Trial Updated:
02/04/2025
Locations: Brown University - Women and Infants Hospital of Rhode Island, Providence, Rhode Island
Conditions: Hyper Bilirubinemia, Premature Infant
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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
NCT06445946
Recruiting
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) randomized to oral metformin versus injectable insulin. This study will determine if metformin is not inferior to insulin in reducing adverse pregnancy outcomes, is comparably safe for exposed individuals and children, and if patient-reported factor... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Brown University, Providence, Rhode Island
Conditions: Gestational Diabetes Mellitus, Pregnancy, High Risk
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Development of a Lifestyle Physical Activity Intervention to Reduce Risk for Perinatal Cannabis Use - RCT
NCT06239701
Recruiting
The overall goal of this pilot study is to develop and preliminarily evaluate an LPA intervention designed to reduce cannabis use during pregnancy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Butler Hospital, Providence, Rhode Island
Conditions: Pregnancy
Register for Updates
Using Family-Based Approaches to Improve Healthy Eating for Southeast Asian Children
NCT05817838
Recruiting
This small scale healthy eating study provides Southeast Asian families with children ages 6 to 11 with a family-based nutrition education, one-on-one interviews to help with motivation to eat health, text messaging, and coupons to purchase health foods and beverages. Since this is a small scale study that is a pilot intervention, the main goal of this intervention is to determine if it is feasible, meaning, can it be done. The second goal of this intervention is to determine if there are meanin... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
02/03/2025
Locations: Brown University, Providence, Rhode Island
Conditions: Diet, Healthy
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Study of PYX-201 in Solid Tumors
NCT05720117
Recruiting
The primary objectives of this study are to determine the recommended dose(s) of PYX-201 for participants with relapsed/refractory (R/R) solid tumors, and to determine the objective response rate (ORR) in participants treated with PYX-201 as a single agent.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Solid Tumor, Advanced Solid Tumor
Register for Updates