Rhode Island is currently home to 495 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Providence, Warwick, East Providence and Johnston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV
NCT03862924
Recruiting
Cigarette smoking is more prevalent (50-70%) in persons living with HIV in the U.S. when compared with the general population and is linked to increased rates of heart disease, lung diseases and infections, and lung cancers. Because of their high levels of nicotine dependence, low quit rates, and familiarity with harm reduction, HIV-positive smokers may view the use of alternative nicotine delivery products, such as electronic cigarettes (ECs), as an attractive option for reducing and eventually... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Brown University School of Public Health, Providence, Rhode Island
Conditions: HIV
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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
NCT04262206
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
06/14/2024
Locations: Providence VA Medical Center, Providence, Rhode Island
Conditions: Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
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Treatment of Calcific Total Occlusions in Peripheral Artery Disease
NCT05551780
Recruiting
Prospective, multi-center, non-randomized, open label, clinical study intended to provide data to demonstrate safety and performance of the SoundBite Crossing System XS Peripheral.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
06/12/2024
Locations: Lifespan - The Miriam Hospital, Providence, Rhode Island
Conditions: Chronic Total Occlusion of Artery of the Extremities
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Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NCT05124808
Recruiting
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
06/09/2024
Locations: Women and Infants Hospital of Rhode Island, Providence, Rhode Island
Conditions: Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
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Project REST: Regulation of Eating and Sleep Topography
NCT04057716
Recruiting
Overweight/obesity and inadequate sleep are prevalent, and frequently co-occurring, health risks among children, both of which are associated with serious medical and psychosocial health complications including risk for cardiovascular disease. Although the investigator's data suggest that disrupted or shortened sleep may be causally associated with increased energy intake and weight gain in children, and with self-regulation and neural response to food cues in adults, understanding of mechanisms... Read More
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
06/06/2024
Locations: Weight Control & Diabetes Research Center, Providence, Rhode Island
Conditions: Obesity, Childhood, Binge Eating, Sleep, Self-regulation
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Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents
NCT05380765
Recruiting
The overall objective of this project is to develop and obtain preliminary data on acceptability, feasibility, and initial efficacy of Native PATHS. This work is guided by the stage model guidelines for treatment development and adaptation 25. Stage 1a will occur in two sequential steps. First, the investigators will recruit youth who are in 5th - 8th grade and their family members (N=24, 12 youth, 12 adults 18+) to participate in three talking circle sessions to obtain feedback on the cultural... Read More
Gender:
ALL
Ages:
Between 10 years and 14 years
Trial Updated:
06/04/2024
Locations: University of Rhode Island, Kingston, Rhode Island
Conditions: Alcohol Drinking, Tobacco Use, Drug Use
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A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas
NCT05641844
Recruiting
The goal of this clinical trial is to assesses the safety of autologous RD2 Ver.02 as compared to a control for managing transsphincteric and intersphinsteric anal fistulas. The main questions it aims to answer are: Assess the safety and efficacy of RD2 Ver.02 in anal fistula application, compared to control. Complication rate by 6 months of anal fistula treatment with RD2 Ver.02 compared to control. Recurrence of anal fistula at 12 months post-treatment Incidence of perirectal infection by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2024
Locations: Brown surgical associates, Providence, Rhode Island
Conditions: Anal Fistula
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A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction
NCT03776162
Recruiting
This study is designed to evaluate bridge-enhanced ACL restoration (BEAR), a new surgical technique for repairing knees injured by a tear of the anterior cruciate ligament (ACL) that promotes reattachment and healing of the ACL using a blood-enriched implant. BEAR will be compared to bone to patellar tendon to bone autograft (BPTB) reconstruction, a standard ACL surgical reconstruction technique that replaces a torn portion of the ACL with transplanted patellar tendon tissue, and thus requires a... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/31/2024
Locations: University Orthopedics Institute/ Rhode Island Hospital, Providence, Rhode Island
Conditions: Anterior Cruciate Ligament Tear
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Cognitive Control & the Functional Organization of the Frontal Cortex
NCT06436209
Recruiting
The goal of this basic experimental clinical trial is to understand the effect of multitasking practice on the structure of neural representations of tasks in the human lateral prefrontal cortex and control brain regions. The main question it aims to answer is: What changes in neural representational structure predict improvements in multitasking behavior due to multitasking practice? Healthy human participants will learn two independent tasks, each mapping a set of stimuli to motor responses ba... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
05/29/2024
Locations: Metcalf Research Building, Brown University & MRI Research Facility, Brown University, Providence, Rhode Island
Conditions: Multitasking Behavior and Neural Representations Associated With Multitasking Ability, Healthy Volunteers, Executive Function
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A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors
NCT05584670
Recruiting
This is a Phase 1/2, open label, multiple cohort study to assess the safety and preliminary efficacy of SAR445877 as a monotherapy or in combination with other anticancer therapies for participants aged at least 18 years with advanced unresectable or metastatic solid tumors. The study will include 2 parts: A dose escalation Part 1: for finding the therapeutic dose(s) of SAR445877 in a monotherapy given every 2 weeks (Q2W) or weekly (QW) and in combination with other anticancer therapies when a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2024
Locations: Rhode Island Hospital Site Number : 8400004, Providence, Rhode Island
Conditions: Solid Tumor
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The Re-Prosper HF Study
NCT04551222
Recruiting
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of physical and mental health status and carries a high risk of mortality. Even though significant progress has been made in understanding the disease process, currently, its management and treatment is limited. The investigators have discovered that a commonly used drug for the treatment of gout can be repurposed for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Providence VA Medical Center, Providence, RI, Providence, Rhode Island
Conditions: Heart Failure
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Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer
NCT05997017
Recruiting
A Phase 2 Multi-center Open-label Trial of nab-Sirolimus in Combination with Letrozole in Advanced or Recurrent Endometrioid Endometrial Cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/20/2024
Locations: Women & Infants Hospital, Providence, Rhode Island
Conditions: Endometrial Cancer, Endometrioid Tumor, Cancer, Tumor, Recurrent Endometrial Carcinoma, Endometrioid Endometrial Cancer
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