There are currently 2869 clinical trials in Houston, Texas looking for participants to engage in research studies. Trials are conducted at various facilities, including M D Anderson Cancer Center, University of Texas MD Anderson Cancer Center, Baylor College of Medicine and The University of Texas - MD Anderson Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Establishing a Tumor Registry of Patients With Mesonephric-like Adenocarcinoma (MLA)
NCT06377527
Recruiting
To develop a database of medical information about patients with MLA in an effort to increase our understanding of the characteristics of MLA, which is the rarest form of endometrial carcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Mesonephric-like Adenocarcinoma
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Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States
NCT06435286
Recruiting
In a previous clinical trial in China and the United States (US), the investigators developed and validated a mobile, high-resolution microendoscope (mHRME) for screening and surveillance of esophageal squamous cell neoplasia (ESCN). The trial revealed higher specificity for qualitative (visual) interpretation by experts but not the novice and in the surveillance arm (100% vs. 19%, p \<0.05). In the screening arm, diagnostic yield (neoplastic biopsies/total biopsies) increased 3.6 times (8 to 29... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Baylor St. Luke's Medical Center, Houston, Texas +1 locations
Conditions: Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
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BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)
NCT04982393
Recruiting
The purpose of this study is to describe the natural history and progression of patients diagnosed with PH1, and to characterize the long-term real-world safety and effectiveness of lumasiran.
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2025
Locations: Clinical Trial Site, Houston, Texas
Conditions: Primary Hyperoxaluria Type 1
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APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML
NCT06634394
Recruiting
A multi-center, open-label, dose-finding study of five dose levels of APVO436 in combination with venetoclax and azacitidine (ven/aza) in adult patients with newly diagnosed, CD123+ AML.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Acute Myeloid Leukemia (AML)
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Validating Innovative Biosensors for Rett Autonomic Symptom Tracking
NCT06338267
Recruiting
The VIBRANT study aims to validate biosensors to objectively and directly measure symptoms in Rett syndrome and create confidence in the use of these devices in clinical trials. VIBRANT will use several FDA-cleared wearable biosensors and a non-wearable device to collect symptom data from patients with Rett syndrome for up to 9 weeks. Symptoms of interest include heart rate, breathing, sleep, blood oxygen levels, and movement. Participants will use the biosensors intermittently at home, document... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/09/2025
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Rett Syndrome
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Study of DNL126 in Pediatric Participants With Mucopolysaccharidosis Type IIIA (Sanfilippo Syndrome Type A)
NCT06181136
Recruiting
This is a multicenter, open-label, Phase 1/2 study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and clinical efficacy of DNL126 in participants with Sanfilippo syndrome Type A (MPS IIIA). The core study period is 25 weeks (approximately 6 months) and is followed by a 72-week (approximately 18 month) open-label extension (OLE). Participants with MPS IIIA will be enrolled in two planned cohorts, and additional participants with MPS IIIA may be enrolled in three... Read More
Gender:
ALL
Ages:
Between 0 years and 18 years
Trial Updated:
05/09/2025
Locations: Baylor College of Medicine and Texas Children's Hospita, Houston, Texas
Conditions: Mucopolysaccharidosis Type IIIA
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Impact of Aminoglycosides in Hypotensive Septic Oncology Patients
NCT05045963
Recruiting
This study evaluates the impact of aminoglycosides in hypotensive septic oncologic patients. In the oncologic patient population, sepsis is a major health concern due to high mortality rates and healthcare costs. Prior research shows aminoglycosides antibiotics are frequently used to treat sepsis, but their clinical impact in hypotensive oncology patients upon the progression of sepsis is not known.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Septicemia
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A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients Relapsed/Refractory Hodgkin's Lymphoma
NCT05355051
Recruiting
This study is a Phase II single-center clinical trial designed to assess the efficacy, safety, and tolerability of pembrolizumab in combination with the 7-day regimen of azacitidine for the treatment of relapsed/refractory HL.
Gender:
ALL
Ages:
1 year and above
Trial Updated:
05/09/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Hodgkin's Lymphoma
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Evaluating Mechanical Properties of Post-Mastectomy Skin Flaps to Estimate Reconstruction Risks, the EMPOWER Study
NCT06584396
Recruiting
This study evaluates the skin and surrounding soft tissue that is removed during an implant reconstruction after a mastectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Breast Carcinoma
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Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
NCT05609578
Recruiting
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Local Institution - 017-848, Houston, Texas
Conditions: Advanced NSCLC, Metastatic Lung Cancer
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Pentoxifylline in Diabetic Kidney Disease
NCT03625648
Recruiting
Pentoxifylline (PTX) is a medication that has been on the market since 1984 for use in disease in the blood vessels of the legs. There is some preliminary information that it may protect the kidneys from damage due to diabetes and other diseases. "Pentoxifylline in Diabetic Kidney Disease" is a study to bee conducted in 40 VA hospitals across the nation to determine definitively whether or not PTX can prevent worsening of kidney disease and delay death in patients with diabetic kidney disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas
Conditions: Diabetic Kidney Disease
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Phase 1 Dose Escalation and Dose Expansion Trial of NP-101 in Patients With Solid Tumors
NCT06563375
Recruiting
To evaluate the safety and preliminary efficacy of NP-101 in patients with solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Solid Tumor
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