2026 Effect of Sleep Clinical Trials, Research & Treatment

What is it? Conditions Maintaining Medical Research Clinical Trials More Conclusion

What is Sleep?

Although everyone needs to sleep to maintain their health, the question “what is sleep?” has proven surprisingly difficult. During the state of sleep, the brain exhibits profound changes.

It is now believed the function of sleep is to clear metabolic waste products from the pathways of the brain. This helps explain why healthy sleep must be sufficient in both duration and depth.

What Conditions Are Associated With Sleep?

The most common health condition associated with sleep is insomnia. Insomnia is difficulty falling asleep, staying asleep, or both. Sleep disturbances can be physiological in nature (for example, Restless Legs Syndrome) or psychological (for example, nightmares.)

Experts have estimated that about 25% of Americans develop some degree of insomnia in any given year. In 75% of cases, it passes without long-term damage to sleep habits.

Other common sleep disorders include:

Snoring
Sleep apnea, “pauses” in breathing often caused by soft tissue blockage in the airway
Sleep hypoventilation, trouble breathing in sleep caused by respiratory muscle weakness
Restless Legs Syndrome, which causes discomfort only alleviated by moving the legs
Bruxism, the grinding of the teeth during sleep, which can damage the teeth and jaw

Sleep medicine experts also recognize several less common sleep disorders. These include things like narcolepsy, nightmares and night terrors, and Rapid Eye Movement Behavior Disorder.

Maintaining Sleep Health

Many chronic sleep conditions arise with no known cause. However, maintaining good sleep hygiene can help. Sleep hygiene refers to the whole collection of habits that affect sleep health.

In general, it is a good idea to develop a consistent bedtime and routine for “going to bed.” Discontinue the use of phones and other “screens” an hour before bed, since the blue light of these devices inhibits the brain’s natural response to reduced lighting at night.

Remember, many factors can contribute to sleep health issues:

Certain medications, such as those used for high blood pressure and asthma
Chronic pain disorders and other conditions that cause persistent discomfort
Stress in your personal or work life and conditions like anxiety or depression

Each individual has a slight variance in sleep need. Likewise, the duration of sleep needed does change depending on life stage. However, it is important to know everyone needs about eight hours of nightly sleep to maintain mental and physical health.

Medical Research on Sleep

With the answers to key questions on “why do we sleep?” coming into view, sleep researchers are continuing to pursue clinical sleep studies looking for new sleep disorder treatments.

Sleep clinical care has undergone revolutionary changes in recent years thanks to imaging technology that precisely pinpoints sleep-related changes in the human brain at any age.

Current Clinical Trials on Sleep

This list includes all clinical trials on sleep recognized by ClinicalTrials.gov. To add sleep clinical trials to our list, contact us.

Foot Reflexology and Ta-VNS for Symptom Management in Head and Neck Cancer During CCRT
on July 24, 2026 at 4:00 am
Conditions: Head and Neck Neoplasms; Xerostomia; Cancer-related Fatigue; Pain Interventions: Procedure: True Foot Reflexology; Procedure: Sham Foot Reflexology; Device: True ta-VNS; Device: Sham ta-VNS; Procedure: True Auricular Acupressure; Procedure: Sham Auricular Acupressure; Other: Usual Care Sponsors: Tzu Chi University; Hualien Tzu Chi General Hospital Recruiting
The Beneficial Effects of Naps on Motor Learning
on July 24, 2026 at 4:00 am
Conditions: Stroke Interventions: Device: MRI system; Device: MEG system Sponsors: National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)
on July 24, 2026 at 4:00 am
Conditions: Excessive Sleepiness; Shift-work Disorder Interventions: Drug: Solriamfetol 150 mg; Drug: Solriamfetol 300 mg; Drug: Placebo Sponsors: Axsome Therapeutics, Inc. Recruiting
Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement Device
on July 24, 2026 at 4:00 am
Conditions: Hydrocephalus Interventions: Device: wireless thermal anisotropy measurement device Sponsors: Rhaeos, Inc.; National Institute of Neurological Disorders and Stroke (NINDS) Recruiting
FR-taVNS Tinnitus Tria
on July 24, 2026 at 4:00 am
Conditions: Tinnitus Interventions: Procedure: True Foot Reflexology; Procedure: Sham Foot Reflexology; Device: True ta-VNS; Device: Sham ta-VNS; Procedure: True Auricular Acupressure; Procedure: Sham Auricular Acupressure; Other: Usual Care Sponsors: Tzu Chi University Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
on July 24, 2026 at 4:00 am
Conditions: Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms Interventions: Drug: Solriamfetol 150 MG; Drug: Placebo Sponsors: Axsome Therapeutics, Inc. Recruiting
Identification of Biomarkers of Obstructive Sleep Apnea.
on July 23, 2026 at 4:00 am
Conditions: Obstructive Sleep Apnea; Obstructive Sleep Apnea (OSA); Obstructive Sleep Apnea (OSAS); Obstructive Sleep Apnea (SAOS); Obstructive Sleep Apnea (Moderate to Severe) Interventions: Device: Positive Airway Pressure (PAP) Therapy Sponsors: Medical University of Bialystok; National Science Centre, Poland Recruiting
Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury
on July 23, 2026 at 4:00 am
Conditions: Acquired Brain Injury (Including Stroke) Sponsors: University of Oxford Recruiting
An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)
on July 23, 2026 at 4:00 am
Conditions: REM Sleep Behavior Disorder Interventions: Drug: Adalimumab; Drug: Placebo Sponsors: Yale University; The Marcus Foundation; National Institute on Aging (NIA) Recruiting
Predictive Factors for Occlusal Changes in Obstructive Sleep Apnea Treatment With Mandibular Advancement Appliance
on July 23, 2026 at 4:00 am
Conditions: Obstructive Sleep Apnea Syndrome Interventions: Device: Mandibular Advancement Device Sponsors: University Hospital, Toulouse Recruiting
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
on July 22, 2026 at 4:00 am
Conditions: PANS; Pediatric Acute-Onset Neuropsychiatric Syndrome Interventions: Diagnostic Test: Psycodiagnostic evaluation; Diagnostic Test: Polysomnography; Diagnostic Test: 1H-NMR analysis; Diagnostic Test: miRNA sequencing Sponsors: University of Cagliari; University of Palermo; Azienda Ospedaliera Universitaria Policlinico "G. Martino"; Oasi Research Institute-IRCCS; Universita Telematica E-Campus; Azienda Ospedaliero Universitaria di Cagliari Recruiting
Disentangling the Role of Depression in Hypersomnia
on July 22, 2026 at 4:00 am
Conditions: Hypersomnia Interventions: Diagnostic Test: Sleep study Sponsors: University of Pennsylvania; Jazz Pharmaceuticals Recruiting

Why Are More Clinical Trials on Sleep Necessary?

There may be no single “cure for insomnia”, but clinical trials on sleep help doctors develop effective sleep disorder treatment protocols for the various situations where sleep is disturbed.

Ongoing sleep research continues to redefine what we know about each of these conditions. Insomnia treatments are just one of the new sleep clinical resources coming from this effort.

Conclusion

The majority of American adults experience sleep disturbances at some point in life. With that in mind, clinical trials on sleep truly affect everyone. Unfortunately, sleep disorders are under-diagnosed – and those who suffer often do not pursue treatment. Participating in clinical studies on sleep is one way to help ensure you, and others, will rest better.