A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact
NCT03969992
Recruiting
The purpose of this two-part Phase 2 study is to assess the safety, tolerability and efficacy of aerosolized SF-RI 1 (AeroFact) when delivered via nCPAP at two different doses.
Gender:
All
Ages:
Between 26 weeks and 31 weeks
Trial Updated:
02/22/2022
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Respiratory Distress Syndrome in Premature Infant
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PEN-866 in Patients With Advanced Solid Malignancies
NCT03221400
Recruiting
Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2022
Locations: Highlands Oncology Group, Springdale, Arkansas
Conditions: Carcinoma, Endometrial Adenocarcinoma, Neoplasms, Squamous Cell Carcinoma of the Anus, Adenocarcinoma of the Pancreas, Advanced Cancer, Solid Tumor, Solid Carcinoma, Squamous Cell Carcinoma of the Cervix, Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Vulva, Squamous Cell Carcinoma of the Penis, Gastric Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small-cell Lung Cancer, Small Cell Lung Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Adenocarcinoma
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Web Based Orthopaedic Sports Medicine Registry
NCT01191151
Recruiting
The purpose of this study is to establish an international, web based clinical registry to collect baseline characteristics of patients undergoing orthopaedic, sports medicine, arthroscopy, and related surgery, and the subsequent outcomes and cost-effectiveness associated with the surgical procedures and nonoperative treatments.
Gender:
All
Ages:
12 years and above
Trial Updated:
02/13/2022
Locations: Agility Center, Bentonville, Arkansas
Conditions: Degenerative and Traumatic Pathology of the Knee, Degenerative and Traumatic Pathology of the Shoulder and Elbow, Degenerative and Traumatic Pathology of the Foot and Ankle, Degenerative and Traumatic Pathology of the Hand and Wrist, Degenerative and Traumatic Pathology of the Hip
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Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis
NCT05142774
Recruiting
This is an open-label, long-term multicenter, study to evaluate the safety and efficacy of topical tapinarof cream, 1% in subjects with atopic dermatitis. Subjects in this study have completed treatment in one of two Phase 3 pivotal studies (DMVT-505-3101 or DMVT-505-3102) or completed treatment in the DMVT-505-2104 study, or directly enrolled into this study. This study will consist of up to 48 weeks of treatment and a 1 week safety follow-up period.
Gender:
All
Ages:
2 years and above
Trial Updated:
01/28/2022
Locations: Dermavant Clinical Site, Bryant, Arkansas
Conditions: Atopic Dermatitis
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Feasibility Testing an Exercise Program to Improve Cognition for T2DM Patients
NCT04590833
Recruiting
This proposed study will advance science by providing evidence on the feasibility of a standardized, rigorously designed and delivered exercise program to improve cognition and plasma brain-derived neurotrophic factor (BDNF) levels for individuals with type 2 diabetes. We will also explore how certain genetic variant may influence exercise-induced cognitive improvements and plasma BDNF levels. Findings of the proposed study will establish a comprehensive knowledge base for future research and de... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/07/2022
Locations: University of Arkansas, Fayetteville, Arkansas
Conditions: Diabetes Mellitus, Type 2
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vDOT for Newly Diagnosed Pediatric Asthma
NCT05120323
Recruiting
The goal of this research study is to compare the impact of video directly observed therapy on inhaler technique accuracy with participants receiving video directly observed therapy vs. participants receiving standard asthma care. Participants will be randomized between the two groups. We will follow up and compare the two groups to see if they have improved asthma control as measured by symptom-free days, higher inhaler technique at 3-month follow up, higher checklist scores on a standardized i... Read More
Gender:
All
Ages:
Between 6 years and 11 years
Trial Updated:
12/14/2021
Locations: Arkansas Children's Hospital, Little Rock, Arkansas
Conditions: Asthma in Children
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Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.
NCT05024695
Recruiting
Evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.
Gender:
All
Ages:
46 years and above
Trial Updated:
08/23/2021
Locations: Vold Vision, Fayetteville, Arkansas
Conditions: Glaucoma
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Community Translation of the Expecting Study
NCT04298125
Recruiting
The Expecting intervention as delivered in prior studies in a clinical setting is described in a previous approved IRB submission (Protocol 202954). The current project will seek to engage community stakeholders to translate Expecting to a community-delivered intervention and to test its acceptability, feasibility, and fidelity in a proof of principle study with 60 expecting mothers.
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/30/2021
Locations: Arkansas Children's Nutrition Center, Little Rock, Arkansas
Conditions: Pregnancy Related
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Time Restricted Feeding, Muscle, and Metabolism
NCT04949451
Recruiting
Effective nutrition strategies for combatting and/or preventing obesity still need to be identified. This has been the case despite the numerous and different approaches that have been taken. Potential targets for combatting/preventing obesity have been identified, but long-term solutions have not emerged. This study uses time restricted feeding to study the role of dietary protein in obesity prevention and/or treatment. The objectives are to determine the role of skeletal muscle mass as a drive... Read More
Gender:
All
Ages:
Between 25 years and 50 years
Trial Updated:
06/25/2021
Locations: University of Arkansas, Fayetteville, Arkansas
Conditions: Overweight, Obesity
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Diet and Health in Adults With Metabolic Syndrome
NCT03935048
Recruiting
The prevalence of US adults with Metabolic Syndrome (MetS) is over 34%, impacting nearly 35% of all adults and 50% of those aged 60 years or older. MetS is characterized as a combination of underlying risk factors that when, occurring together, increase the risk for chronic diseases such as type 2 diabetes mellitus (T2DM), cardiovascular disease, stroke, and certain types of cancer, resulting in an 1.6-fold increase in mortality. According the American Heart Association, health risks associated... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/16/2021
Locations: University of Arkansas, Fayetteville, Arkansas
Conditions: Metabolic Syndrome
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Pilot Study on the Effects of Low-Level Laser Therapy Treatment for Acute and Persistent Discomfort
NCT04774783
Recruiting
This study will examine the effectiveness of Low-Level Laser Therapy (LLLT) for the management of pain in various locations of the body. All subjects selected for participation in the study will be assigned to a LLLT treatment group for a duration of 12 sessions.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/24/2021
Locations: Arkansas Colleges of Health Education, Fort Smith, Arkansas
Conditions: Chronic Pain, Acute Pain
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Little Rock, Arkansas
Conditions: Ulcerative Colitis
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