There are currently 79 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, Texas, California and New York.
A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
NCT06388707
Recruiting
This will be a prospective, open-label, single-arm, multi-center, pilot study to evaluate the safety, tolerability, and preliminary efficacy of low-intensity focused ultrasound (LIFU) neuromodulation using NaviFUS System in patients with drug-resistant unilateral or bilateral temporal lobe epilepsy (DR-TLE).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: Stanford University School of Medicine, Palo Alto, California +2 locations
Conditions: Drug Resistant Epilepsy, Epilepsy
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Flexible Representation of Speech
NCT05209386
Recruiting
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratempo... Read More
Gender:
ALL
Ages:
Between 15 years and 25 years
Trial Updated:
05/02/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Epilepsy
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Ear-Seizure Detection (EarSD) Study
NCT06598189
Recruiting
The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD)) by simultaneous recording with conventional video-EEG (Electroencephalogram) on patients with epileptic seizures in the Epilepsy Monitoring Unit of the hospital.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Ummmc-Memorial Campus, Worcester, Massachusetts +1 locations
Conditions: Seizures, Epilepsy
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Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery
NCT06280092
Recruiting
This study is a non-randomized, open label, phase 1 clinical trial to evaluate the fesibility and safety of intrathalamic delivery of MSCs during standard of care DBS surgery for epilepsy. Subjects will be screened at our outpatient clinic and interested qualified subjects will be consented and offered participation in this trial. Once consent has been obtained, patients will undergo a standard preoperative evaluation which includes baseline laboratory values and a high-definition MRI. Patients... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/21/2025
Locations: Mayo Clinic, Jacksonville, Florida
Conditions: Epilepsy
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Microelectrode Recordings From the Vagus Nerve in Awake Humans
NCT06016686
Recruiting
This Anchillary project uses a refined technique of ultrasound-guided microneurography of the human cervical vagus nerve, an approach developed by Professor Vaughan Macefield and used safely to-date in 44 prior study participants. The overall goal of this project is to build upon prior data obtained using this approach by undertaking a detailed neurophysiological investigation of the human vagus nerve and to identify the nerve fibers activated during vagal nerve stimulation (VNS) in participant... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/20/2025
Locations: University of Minnesota, Minneapolis, Minnesota +1 locations
Conditions: Epilepsy
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Invasive Brain-Computer Interfaces for Attention
NCT06940089
Recruiting
The goal of this interventional study is to compare if the use of a brain-machine interface (BCI) therapy can improve the symptoms of attentional deficit by producing brain changes in the networks that modulate attention. The investigators intend to work with epileptic participants who do not respond to pharmacological treatment, who will undergo neurosurgery. The questions the study sets out to answer are: 1. is there an improvement of symptoms in an experimental group receiving the treatment... Read More
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
04/18/2025
Locations: Dell Children's Medical Center, Austin, Texas
Conditions: Epilepsy in Children, Epilepsy
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Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding
NCT05450978
Recruiting
This project focuses on anti-seizure medication (ASM) clearance and physiological factors determining blood concentrations in pregnant adult women with epilepsy and amounts of exposure to their unborn children and nursing infants.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/15/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Epilepsy, Pregnancy Related
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Intracranial Stimulation Mapping In Epilepsy
NCT05290610
Recruiting
This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Epilepsy
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Implementation and Cost Evaluation of Project UPLIFT
NCT06865820
Recruiting
This study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulness, for well-being and costs. Project UPLIFT is delivered as weekly sessions over 8 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Rollins School of Public Health, Atlanta, Georgia
Conditions: Epilepsy
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Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
NCT05361070
Recruiting
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal epilepsy among children with acute provoked neonatal seizures. The researchers aim to develop prediction rules to stratify neonates into low, medium, and high risk for post-neonatal epilepsy based on clinical, electroencephalogram (EEG), magnetic resonance... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/02/2025
Locations: University of California, San Francisco, San Francisco, California +7 locations
Conditions: Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhage, Epilepsy, Gene Abnormality
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Patterns of Neurodevelopmental Disorders
NCT06213090
Recruiting
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
Gender:
ALL
Ages:
All
Trial Updated:
04/01/2025
Locations: Rossignol Medical Center, Phoenix, Arizona
Conditions: Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome, Down Syndrome, Epilepsy, Mitochondrial Encephalomyopathies, Cerebral Folate Deficiency
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Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits
NCT04419272
Recruiting
Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of attention deficit hyperactivity disorder (ADHD). It is unknown, however, if stimulants would be of benefit for memory and thinking problems due to epilepsy. In this study, participants will be assigned randomly (i.e., by flip of a coin), to a group that takes MPH and a group that takes a placebo (sugar pill). Participants will not know the group to which they have been assigned. Tests of attention and memory will be complete... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Miami VA Healthcare System, Miami, FL, Miami, Florida +3 locations
Conditions: Epilepsy
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