There are currently 85 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, California, Texas and New York.
Localizing Epileptic Networks Using MRI and iEEG
NCT04649008
Recruiting
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 milli... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
ALL
Ages:
Between 1 day and 6 months
Trial Updated:
01/17/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +10 locations
Conditions: Tuberous Sclerosis Complex, Epilepsy
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Prediction of Anxiety and Memory State
NCT06551090
Recruiting
The purpose of this study is to look at how signals in the brain, body, and behavior relate to anxiety and memory function. This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware/software system for measuring human brain-behavior relationships. The R61 portion of the project is designed to develop the CAMERA platform, which will use multimodal, passive sensor data to predict anxiety-memory stat... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/16/2025
Locations: Columbia University, New York, New York
Conditions: Anxiety, Memory, Epilepsy
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RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS
NCT06143293
Recruiting
The acute and chronic effects of VNS stimulation on various on the autonomic nervous, cardiovascular, immune, and metabolic systems will be compared from noninvasive and minimally invasive physiological recordings and blood draws at various time points throughout the study. These interventions and assessments will be performed in individuals 18 years of age and older who are implanted with a VNS device, which consists of patients who have been diagnosed with drug resistant epilepsy or major depr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Epilepsy, Depressive Disorder
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Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
NCT06695767
Recruiting
The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, Texas +1 locations
Conditions: Major Depressive Disorder, Epilepsy
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Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery
NCT06280092
Recruiting
This study is a non-randomized, open label, phase 1 clinical trial to evaluate the fesibility and safety of intrathalamic delivery of MSCs during standard of care DBS surgery for epilepsy. Subjects will be screened at our outpatient clinic and interested qualified subjects will be consented and offered participation in this trial. Once consent has been obtained, patients will undergo a standard preoperative evaluation which includes baseline laboratory values and a high-definition MRI. Patients... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/02/2025
Locations: Mayo Clinic, Jacksonville, Florida
Conditions: Epilepsy
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MEHMO Natural History and Biomarkers
NCT06019182
Recruiting
This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have symptoms such as intellectual delay, seizures, abnormal hormone and blood sugar levels, and decreased motor skills. No current treatment for these conditions is available. A major impediment to the testing of potential therapeutic interventions is the lack of well-defined o... Read More
Gender:
ALL
Ages:
Between 1 week and 100 years
Trial Updated:
12/27/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Intellectual Disability, Epilepsy, Hypogonadisms, Microcephaly, Nervous System Malformations, Obesity
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Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
NCT04322734
Recruiting
The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting. There is no cost for visits or study-related exams.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
12/23/2024
Locations: Southwestern Research and Resource Center, Phoenix, Arizona +1 locations
Conditions: Autism Spectrum Disorder, Mitochondrial Pathology, Epilepsy, Brain Tumor, Psychiatric Disorder, Mitochondrial Diseases
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A Novel Social Emotional Learning Curriculum for Youth With Epilepsy
NCT06427967
Recruiting
Youth with epilepsy (YWE) are significantly more likely than their peers without epilepsy to experience isolation, interpersonal victimization, and low relationship satisfaction. This is a serious health concern. Poor social support, real or perceived, is consistently correlated to worsened outcomes in every domain of health-related quality of life. As YWE are two to five times more likely than their peers without epilepsy to develop a mental health condition, poor social support is likely a bid... Read More
Gender:
ALL
Ages:
Between 12 years and 26 years
Trial Updated:
12/23/2024
Locations: Boston Medical Center, Neurology and remote, Boston, Massachusetts
Conditions: Epilepsy
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A Double Blind, Randomized, Cross-over Study Examining the Suppression of the Photoparoxysmal EEG Response With NPT 2042
NCT06525649
Recruiting
A double-blind, placebo-controlled, crossover trial to investigate the PPR of approximately 5 subjects with a known stable PPR on EEG, using 2 doses of NPT 2042 compared to placebo.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/19/2024
Locations: Clinical Trials, Inc. (CTI), Little Rock, Arkansas +1 locations
Conditions: Photosensitive Epilepsy, Epilepsy
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A Study of Detection of Paroxysmal Events Utilizing Computer Vision and Machine Learning (USF)
NCT06705439
Recruiting
Increased computational power has made it possible to implement complex image recognition tasks and machine learning to be implemented in every day usage. The computer vision and machine learning based solution used in this project (Nelli) is an automatic seizure detection and reporting method that has a CE mark for this specific use. The present study will provide data to expand the utility and detection capability of NELLI and enhance the accuracy and clinical utility of automated computer vi... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/28/2024
Locations: Tampa General Hospital, Tampa, Florida
Conditions: Epilepsy
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A Study of Detection of Paroxysmal Events Utilizing Computer Vision and Machine Learning - Nelli
NCT05606575
Recruiting
Nelli is a video-based non-EEG physiological seizure monitoring system. This study is a blinded comparison of Nelli's identified events to gold-standard video EEG review in at-rest pediatric subjects with suspected motor seizures.
Gender:
ALL
Ages:
Between 6 years and 21 years
Trial Updated:
11/28/2024
Locations: The University of Tennessee Health Science Center, Memphis, Tennessee
Conditions: Epilepsy
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