There are currently 78 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Autism participants are Florida, California, Texas and New York.
RNS System RESPONSE Study
NCT04839601
Recruiting
To demonstrate that the RNS System is safe and effective as an adjunctive therapy in individuals age 12 through 17 years with medically refractory partial onset epilepsy.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
02/06/2024
Locations: Children's Health of Orange County, Orange, California +8 locations
Conditions: Epilepsy, Partial Seizure, Neurostimulator; Complications, Drug Resistant Epilepsy, Focal Epilepsy
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Localizing Epileptic Networks Using MRI and iEEG
NCT04649008
Recruiting
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 milli... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe
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Flexible Representation of Speech
NCT05209386
Recruiting
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratempo... Read More
Gender:
All
Ages:
Between 15 years and 25 years
Trial Updated:
02/02/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Epilepsy
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Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
NCT03900468
Recruiting
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: Barrow Neurological Institute, Phoenix, Arizona +20 locations
Conditions: Epilepsy
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Acute Modulation of Stereotyped High-Frequency Oscillations
NCT05439655
Recruiting
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver ta... Read More
Gender:
All
Ages:
Between 3 years and 70 years
Trial Updated:
01/18/2024
Locations: Baylor College of Medicine, Houston, Texas +1 locations
Conditions: Epilepsy
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Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding
NCT05450978
Recruiting
This project focuses on anti-seizure medication (ASM) clearance and physiological factors determining blood concentrations in pregnant adult women with epilepsy and amounts of exposure to their unborn children and nursing infants.
Gender:
Female
Ages:
Between 14 years and 45 years
Trial Updated:
01/16/2024
Locations: Kaufmann Medical Building, Pittsburgh, Pennsylvania
Conditions: Epilepsy, Pregnancy Related
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Genetics of Epilepsy and Related Disorders
NCT01858285
Recruiting
Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to epilepsy and related disorders. These findings may help explain the broad spectrum of clinical characteristics and outcomes seen in people with epilepsy.
Gender:
All
Ages:
All
Trial Updated:
01/11/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy, Epileptic Encephalopathy, Ohtahara Syndrome, Infantile Spasms, Dravet Syndrome, Early Myoclonic Epileptic Encephalopathy, PCDH19-related Epilepsy and Related Conditions, KCNQ2-Related Epileptic Encephalopathy, Epilepsy of Infancy With Migrating Focal Seizures (Disorder)
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ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators
NCT01590862
Recruiting
We propose to study approach/avoidance behavior as measured by the Approach Avoidance task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of VC/VS electrical stimulation on approach-avoidance conflict in 20 adult patients who have undergone DBS implantation for severe MDD and/or OCD. There are 100-200 patients in the world with DBS electrodes in the VC/VS, and our research team ca... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/10/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Obsessive Compulsive Disorder, Major Depressive Disorder, Epilepsy
Register for Updates
PatientSpot Formerly Known as ArthritisPower
NCT03840928
Recruiting
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with rheumatoid arthritis (RA), spondyloarthritis (SpA), other musculoskeletal conditions, chronic neurological conditions like migraine, chronic pulmonary conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, autoimmune dermatological conditions such as psor... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
12/12/2023
Locations: Global Healthy Living Foundation, Upper Nyack, New York
Conditions: Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout, Crohn Disease, Juvenile Idiopathic Arthritis, Lupus Erythematosus, Myositis, Osteoarthritis, Osteoporosis, Psoriasis, Psoriatic Arthritis, Scleroderma, Dermatomyositis, Inflammatory Bowel Diseases, Polymyositis, Axial Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis, Polymyalgia Rheumatica, Giant Cell Arteritis, Temporal Arteritis, Wegener, Relapsing Polychondritis, Undifferentiated Connective Tissue Disease, Spinal Cord Injuries, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Ataxia, Bell Palsy, Brain Tumor, Cerebral Aneurysm, Epilepsy, Guillain-Barre Syndrome, Headache, Head Injury, Hydrocephalus, Lumbar Disc Disease, Meningitis, Multiple Sclerosis, Muscular Dystrophy, Neurocutaneous Syndromes, Parkinson Disease, Stroke, Cluster Headache, Tension-Type Headache, Chronic Obstructive Pulmonary Disease, Asthma, Lung Cancer, Cystic Fibrosis, Sleep Apnea, Eczema, Alopecia, Chronic Inflammation, Unstable Angina, Heart Attack, Heart Failure, Arrythmia, Valve Heart Disease, High Blood Pressure, Congenital Heart Disease, Peripheral Arterial Disease, Diabetes, Chronic Liver Disease, Obesity
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Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Temporal Lobe Epilepsy
NCT04526418
Recruiting
The 24/7 EEG™ SubQ system will be compared to simultaneously recorded video-EEG in the Epilepsy Monitoring Unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient EEG recording. The present study is a 12-week open-label, prospective study with a paired, comparative design for pivotal evaluation of the safety and effectiveness of the 24/7 EEGTM SubQ system in subjects with temporal lobe epilepsy. 2-5 sites in Europe Up to 5 sites in US, or up to 10 sites if... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/20/2023
Locations: Mayo Clinic, Phoenix, Arizona +5 locations
Conditions: Epilepsy
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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures
NCT04519645
Recruiting
The purpose of the study is to evaluate the efficacy of lacosamide (LCM) versus an Active Comparator chosen based on standard of care (StOC) in severe and nonsevere seizure burden (defined as total minutes of electroencephalographic neonatal seizures (ENS) per hour) in neonates with seizures that are not adequately controlled with previous anti-epileptic drug (AED) treatment.
Gender:
All
Ages:
28 days and below
Trial Updated:
11/20/2023
Locations: Sp0968 101, La Jolla, California +24 locations
Conditions: Electroencephalographic Neonatal Seizures, Epilepsy
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SLC13A5 Deficiency Natural History Study - United States Only
NCT06144957
Recruiting
SLC13A5 deficiency (Citrate Transporter Disorder, EIEE 25) is a rare genetic disorder with neurodevelopmental delays and seizure onset in the first few days of life. This natural history study is designed to address the lack of understanding of disease progression. Additionally it will identify clinical and biomarker endpoints for use in future clinical trials.
Gender:
All
Ages:
All
Trial Updated:
11/17/2023
Locations: Lucille Packard Children's Hospital, Stanford University, Palo Alto, California +2 locations
Conditions: Citrate Transporter Deficiency, Epilepsy, Rare Diseases, Movement Disorders, Genetic Disorder, SLC13A5 Deficiency, EIEE25, Kohlschutter-Tonz Syndrome (Non-ROGDI), Citrate Transporter Disorder, DEE25
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