There are currently 85 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, California, Texas and New York.
VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems
NCT03953768
Recruiting
Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of action is not well understood; however it is increasingly recognized that electrical stimulation of the vagus nerve may impact other organ systems in the body including the immune and gastrointestinal systems.... Read More
Gender:
ALL
Ages:
Between 0 years and 60 years
Trial Updated:
11/21/2024
Locations: Norton Healthcare, Louisville, Kentucky +3 locations
Conditions: Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
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SLC13A5 Deficiency Natural History Study - United States Only
NCT06144957
Recruiting
SLC13A5 deficiency (Citrate Transporter Disorder, EIEE 25) is a rare genetic disorder with neurodevelopmental delays and seizure onset in the first few days of life. This natural history study is designed to address the lack of understanding of disease progression. Additionally it will identify clinical and biomarker endpoints for use in future clinical trials.
Gender:
ALL
Ages:
All
Trial Updated:
11/20/2024
Locations: Lucille Packard Children's Hospital, Stanford University, Palo Alto, California +2 locations
Conditions: Citrate Transporter Deficiency, Epilepsy, Rare Diseases, Movement Disorders, Genetic Disorder, SLC13A5 Deficiency, EIEE25, Kohlschutter-Tonz Syndrome (Non-ROGDI), Citrate Transporter Disorder, DEE25
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Genetics of Epilepsy and Related Disorders
NCT01858285
Recruiting
Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to epilepsy and related disorders. These findings may help explain the broad spectrum of clinical characteristics and outcomes seen in people with epilepsy.
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy, Epileptic Encephalopathy, Ohtahara Syndrome, Infantile Spasms, Dravet Syndrome, Early Myoclonic Epileptic Encephalopathy, PCDH19-related Epilepsy and Related Conditions, KCNQ2-Related Epileptic Encephalopathy, Epilepsy of Infancy With Migrating Focal Seizures (Disorder)
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Sleep Spindles and Memory in Rolandic Epilepsy
NCT04569708
Recruiting
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
11/18/2024
Locations: Athinoula A. Martinos Center Biomedical Imaging, Charlestown, Massachusetts
Conditions: Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood, Epilepsy; Seizure, Epilepsy
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Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
NCT04770337
Recruiting
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse even... Read More
Gender:
ALL
Ages:
9 years and above
Trial Updated:
11/14/2024
Locations: Barrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, Arizona +31 locations
Conditions: Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
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RNS System RESPONSE Study
NCT04839601
Recruiting
To demonstrate that the RNS System is safe and effective as an adjunctive therapy in individuals age 12 through 17 years with medically refractory partial onset epilepsy.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
11/12/2024
Locations: Children's Health of Orange County, Orange, California +8 locations
Conditions: Epilepsy, Partial Seizure, Neurostimulator; Complications, Drug Resistant Epilepsy, Focal Epilepsy
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A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
NCT06585605
Recruiting
The Epilepsy-Dyskinesia Study aims to advance the understanding of the clinical and molecular spectrum of epilepsy-dyskinesia syndromes, monogenic diseases that cause both movement disorders and epilepsy. Addressing challenges in rare disease research -such as small, geographically dispersed patient populations and a lack of standardized protocols- the study employs a multinational retrospective survey endorsed by the International Parkinson and Movement Disorder Society. This survey seeks to co... Read More
Gender:
ALL
Ages:
Between 0 years and 18 years
Trial Updated:
10/10/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy in Children, Dyskinesias, Movement Disorders in Children, Neurologic Disorder, Chorea, Myoclonus, Ataxia, Epilepsy, Dystonia Disorder, Movement Disorders
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A Clinical Trial of PRAX-222 in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy
NCT05737784
Recruiting
The goal of this trial is to learn about the effect of PRAX-222 in pediatric participants with early onset SCN2A developmental and epileptic encephalopathy (DEE), aged 2 to 18 years.
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
10/02/2024
Locations: Le Bonheur Childrens Hospital, Memphis, Tennessee +1 locations
Conditions: SCN2A-DEE, Epilepsy
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Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients with Acupuncture Treatment
NCT04677751
Recruiting
The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic epileptiform activity stored by the RNS System
Gender:
ALL
Ages:
Between 15 years and 60 years
Trial Updated:
09/27/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy
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Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
NCT05418894
Recruiting
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform with invasive intracranial recording electrodes provides much-needed spatial and temporal resolution to characterize the neural dynamics of socio-affective processing. The investigators will leverage... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
09/27/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Treatment Resistant Depression, Epilepsy
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Understanding Ketamine's Dissociative Effects (KD Study)
NCT04861051
Recruiting
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Epilepsy
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Human Intracranial Electrophysiology
NCT05529264
Recruiting
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Epilepsy
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