There are currently 75 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Autism participants are Florida, California, Texas and New York.
Functional Brain Mapping for Patients With Epilepsy
Recruiting
We aim to determine the clinical utility of 'dynamic tractography': a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing. We will also determine how well objective electrophysiology biomarkers will improve the prediction of language outcomes following epilepsy surgery. This project will ultimately optimize understanding of how the human brain develops its language network dynamics.
Gender:
All
Ages:
Between 6 months and 21 years
Trial Updated:
02/23/2024
Locations: Children's Hospital of Michigan, Detroit, Michigan +1 locations
Conditions: Epilepsy
MEHMO Natural History and Biomarkers
Recruiting
This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have symptoms such as intellectual delay, seizures, abnormal hormone and blood sugar levels, and decreased motor skills. No current treatment for these conditions is available. A major impediment to the testing of potential therapeutic interventions is the lack of well-defined o... Read More
Gender:
All
Ages:
Between 1 week and 100 years
Trial Updated:
02/22/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Intellectual Disability, Epilepsy, Hypogonadisms, Microcephaly, Nervous System Malformations, Obesity
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Recruiting
Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients undergoing presurgical evaluation for medically refractory epilepsy. To carry out these analyses, we aim to establish an age-stratified normative imaging database using healthy volunteers. Additional objectives are to identify abnormal networks in these patients using re... Read More
Gender:
All
Ages:
Between 8 years and 120 years
Trial Updated:
02/22/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Epilepsy
Epilepsy Learning Healthcare System (ELHS)
Recruiting
The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for epilepsy as envisioned by the National Academies of Medicine Committee in their landmark reports "The Learning Health System" and "Epilepsy Across the Spectrum: Promoting Health and Understanding". The ELHS network is a collaboration among clinicians, patients and researchers that promotes the use o... Read More
Gender:
All
Ages:
All
Trial Updated:
02/15/2024
Locations: Barrow Neurological Institute Comprehensive Epilepsy Center, Phoenix, Arizona +9 locations
Conditions: Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases
Computational Neuroscience of Language Processing in the Human Brain
Recruiting
Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
02/13/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Language, Epilepsy
RNS System LGS Feasibility Study
Recruiting
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or older with Lennox Gastaut Syndrome (LGS) who are refractory to antiseizure medications. The intent is to determine the feasibility and the optimal design of a subsequent pivotal study in order to expand the indication for use for the RNS System as a treatment for patien... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
02/08/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +5 locations
Conditions: Epilepsy, Lennox Gastaut Syndrome, Lennox-Gastaut Syndrome, Intractable, Seizures, Seizures, Generalized
RNS System RESPONSE Study
Recruiting
To demonstrate that the RNS System is safe and effective as an adjunctive therapy in individuals age 12 through 17 years with medically refractory partial onset epilepsy.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
02/06/2024
Locations: Children's Health of Orange County, Orange, California +8 locations
Conditions: Epilepsy, Partial Seizure, Neurostimulator; Complications, Drug Resistant Epilepsy, Focal Epilepsy
Flexible Representation of Speech
Recruiting
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratempo... Read More
Gender:
All
Ages:
Between 15 years and 25 years
Trial Updated:
02/02/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Epilepsy
Localizing Epileptic Networks Using MRI and iEEG
Recruiting
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 milli... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe
Tumor Related Epilepsy
Recruiting
Background: Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tumors. It may completely relieve or greatly reduce the number of seizures they have. Objectives: To evaluate people with brain tumors that are associated with seizures and to offer surgical treatment.... Read More
Gender:
All
Ages:
Between 8 years and 99 years
Trial Updated:
02/01/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Epilepsy, Cancer, Brain Neoplasm
Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
Recruiting
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: Barrow Neurological Institute, Phoenix, Arizona +20 locations
Conditions: Epilepsy
RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS
Recruiting
The acute and chronic effects of VNS stimulation on various on the autonomic nervous, cardiovascular, immune, and metabolic systems will be compared from noninvasive and minimally invasive physiological recordings and blood draws at various time points throughout the study. These interventions and assessments will be performed in individuals 18 years of age and older who are implanted with a VNS device, which consists of patients who have been diagnosed with drug resistant epilepsy or major depr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/28/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Epilepsy, Depressive Disorder