There are currently 76 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, California, Texas and New York.
Brain Metabolism Observed at 7 Tesla
NCT05085704
Recruiting
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla.
Gender:
All
Ages:
Between 16 years and 65 years
Trial Updated:
10/23/2023
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Glut1 Deficiency Syndrome 1, Glucose Metabolism Disorders, Epilepsy, Glut1 Deficiency Syndrome 1, Autosomal Recessive, Glucose Transporter Type 1 Deficiency Syndrome, Glucose Transporter Protein Type 1 Deficiency Syndrome, Glucose Transport Defect
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Pharmacological Modulation of Brain Oscillations in Memory Processing
NCT05594017
Recruiting
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether scopolamine changes memory activity solely at encoding (the time when t... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
10/12/2023
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders, Memory Loss
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Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services
NCT06082999
Recruiting
Overall, this observational cohort study aims too: Implement rapid trio WGS for all children presenting to our health systems with epilepsy onset under 12 months of age. Utilize electronic healthcare records and research databases to unite phenotypic and genomic data and to create a "virtual" registry across all institutions that will promote ongoing discovery. Assess the impact of early genetic diagnosis on epilepsy, developmental, and health economic outcomes through formal longitudinal asses... Read More
Gender:
All
Ages:
12 months and below
Trial Updated:
10/11/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +3 locations
Conditions: Epilepsy
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Collaborative Care for Anxiety and Depression in Epilepsy
NCT05559749
Recruiting
This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/03/2023
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Epilepsy, Anxiety, Depression
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Stimulation-Induced Changes in Fronto-Limbic Network
NCT05854160
Recruiting
The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be comb... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2023
Locations: Epilepsy Monitoring Unit UAB Hospital, Birmingham, Alabama
Conditions: Epilepsy, Mental Disorders
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Human Epilepsy Genetics--Neuronal Migration Disorders Study
NCT00041600
Recruiting
The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.
Gender:
All
Ages:
All
Trial Updated:
09/20/2023
Locations: Boston Children's Hospital, Walsh Laboratory, Boston, Massachusetts
Conditions: Epilepsy, Brain Malformation, Neuronal Migration Disorder, Cognition Disorder
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Neuroliten MVP System Clinical Observation Study
NCT05520476
Recruiting
This is an observational study for data collection from subjects diagnosed with Epilepsy/intractable seizures. The Neuroliten MVP System will not be used for patient management or treatment decisions.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
09/13/2023
Locations: University of Colorado, Loveland, Colorado
Conditions: Epilepsy
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HOBSCOTCH Phase III
NCT04519775
Recruiting
The purpose of this study is to determine the efficacy of an entirely virtual version of the home-based cognitive self-management program "HOBSCOTCH." It will test whether HOBSCOTCH can be delivered nationally from a distance utilizing e-health tools (telephone, computer, and phone).
Gender:
All
Ages:
18 years and above
Trial Updated:
08/28/2023
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Epilepsy
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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
NCT05104983
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
All
Ages:
Between 1 day and 6 months
Trial Updated:
08/21/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama +8 locations
Conditions: Tuberous Sclerosis Complex, Epilepsy
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Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients
NCT00195052
Recruiting
The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging. The investigators propose that the ability to optically monitor neuronal activity in a large area of cortex in "real-time" will be a more sensitive and time-saving method than the electrical methods currently available. The applications of this technique will not only theoretically increase the safety and efficacy of many of neurosu... Read More
Gender:
All
Ages:
Between 6 years and 65 years
Trial Updated:
08/17/2023
Locations: Weill Cornell Medical College/New York Presbyterian Hospital, New York, New York
Conditions: Epilepsy
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Physiological Brain Atlas Development
NCT00575081
Recruiting
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Gender:
All
Ages:
Between 6 years and 90 years
Trial Updated:
08/09/2023
Locations: Vanderbilt Univeristy, Nashville, Tennessee
Conditions: Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor, Epilepsy
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The Neural Code and Dynamics of the Reading Network.
NCT05989893
Recruiting
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional significance to each region involved in cognitive processes as detected by cortical stimulation mapping (CSM) in patients with implanted subdural electrodes (SDE) or depth (sEEG) electrodes, to describe the lo... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/04/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy, Brain Tumor
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