There are currently 81 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, California, Texas and New York.
RNS System RESPONSE Study
NCT04839601
Recruiting
To demonstrate that the RNS System is safe and effective as an adjunctive therapy in individuals age 12 through 17 years with medically refractory partial onset epilepsy.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
11/12/2024
Locations: Children's Health of Orange County, Orange, California +8 locations
Conditions: Epilepsy, Partial Seizure, Neurostimulator; Complications, Drug Resistant Epilepsy, Focal Epilepsy
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A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
NCT06585605
Recruiting
The Epilepsy-Dyskinesia Study aims to advance the understanding of the clinical and molecular spectrum of epilepsy-dyskinesia syndromes, monogenic diseases that cause both movement disorders and epilepsy. Addressing challenges in rare disease research -such as small, geographically dispersed patient populations and a lack of standardized protocols- the study employs a multinational retrospective survey endorsed by the International Parkinson and Movement Disorder Society. This survey seeks to co... Read More
Gender:
ALL
Ages:
Between 0 years and 18 years
Trial Updated:
10/10/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy in Children, Dyskinesias, Movement Disorders in Children, Neurologic Disorder, Chorea, Myoclonus, Ataxia, Epilepsy, Dystonia Disorder, Movement Disorders
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A Clinical Trial of PRAX-222 in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy
NCT05737784
Recruiting
The goal of this trial is to learn about the effect of PRAX-222 in pediatric participants with early onset SCN2A developmental and epileptic encephalopathy (DEE), aged 2 to 18 years.
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
10/02/2024
Locations: Le Bonheur Childrens Hospital, Memphis, Tennessee +1 locations
Conditions: SCN2A-DEE, Epilepsy
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Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients with Acupuncture Treatment
NCT04677751
Recruiting
The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic epileptiform activity stored by the RNS System
Gender:
ALL
Ages:
Between 15 years and 60 years
Trial Updated:
09/27/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy
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Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
NCT05418894
Recruiting
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform with invasive intracranial recording electrodes provides much-needed spatial and temporal resolution to characterize the neural dynamics of socio-affective processing. The investigators will leverage... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
09/27/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Treatment Resistant Depression, Epilepsy
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Understanding Ketamine's Dissociative Effects (KD Study)
NCT04861051
Recruiting
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/24/2024
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Epilepsy
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Human Intracranial Electrophysiology
NCT05529264
Recruiting
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Epilepsy
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Pharmacological Modulation of Brain Oscillations in Memory Processing
NCT05594017
Recruiting
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether scopolamine changes memory activity solely at encoding (the time when t... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/18/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders, Memory Loss
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Physiological Brain Atlas Development
NCT00575081
Recruiting
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Gender:
ALL
Ages:
Between 6 years and 90 years
Trial Updated:
08/30/2024
Locations: Vanderbilt Univeristy, Nashville, Tennessee
Conditions: Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor, Epilepsy
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Epilepsy Learning Healthcare System (ELHS)
NCT06265103
Recruiting
The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for epilepsy as envisioned by the National Academies of Medicine Committee in their landmark reports "The Learning Health System" and "Epilepsy Across the Spectrum: Promoting Health and Understanding". The ELHS network is a collaboration among clinicians, patients and researchers that promotes the use o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/28/2024
Locations: Barrow Neurological Institute Comprehensive Epilepsy Center, Phoenix, Arizona +12 locations
Conditions: Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases
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Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.
NCT06027749
Recruiting
The goal of this clinical trial is to test Epitel's™ Remote EEG Monitoring System's (REMI™) ability to record electroencephalography (EEG) of seizure events in an ambulatory setting for extended periods (14 - 28 days) in patients presenting with questionable seizure characterization. The main questions it aims to answer are: • Can more seizure events be recorded in fourteen (14) days than can be recorded in three (3) days? • Do treating clinicians find clinical value in extended fourteen (14) -... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/26/2024
Locations: University of South Florida, Tampa, Florida +1 locations
Conditions: Epilepsy, Seizures
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Genetic Markers of Cardiovascular Disease in Epilepsy
NCT02824822
Recruiting
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/13/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
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