There are currently 85 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, California, Texas and New York.
Human Intracranial Electrophysiology
NCT05529264
Recruiting
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Epilepsy
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Physiological Brain Atlas Development
NCT00575081
Recruiting
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Gender:
ALL
Ages:
Between 6 years and 90 years
Trial Updated:
08/30/2024
Locations: Vanderbilt Univeristy, Nashville, Tennessee
Conditions: Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor, Epilepsy
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Epilepsy Learning Healthcare System (ELHS)
NCT06265103
Recruiting
The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for epilepsy as envisioned by the National Academies of Medicine Committee in their landmark reports "The Learning Health System" and "Epilepsy Across the Spectrum: Promoting Health and Understanding". The ELHS network is a collaboration among clinicians, patients and researchers that promotes the use o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/28/2024
Locations: Barrow Neurological Institute Comprehensive Epilepsy Center, Phoenix, Arizona +12 locations
Conditions: Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases
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Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.
NCT06027749
Recruiting
The goal of this clinical trial is to test Epitel's™ Remote EEG Monitoring System's (REMI™) ability to record electroencephalography (EEG) of seizure events in an ambulatory setting for extended periods (14 - 28 days) in patients presenting with questionable seizure characterization. The main questions it aims to answer are: • Can more seizure events be recorded in fourteen (14) days than can be recorded in three (3) days? • Do treating clinicians find clinical value in extended fourteen (14) -... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/26/2024
Locations: University of South Florida, Tampa, Florida +1 locations
Conditions: Epilepsy, Seizures
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Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding
NCT05450978
Recruiting
This project focuses on anti-seizure medication (ASM) clearance and physiological factors determining blood concentrations in pregnant adult women with epilepsy and amounts of exposure to their unborn children and nursing infants.
Gender:
FEMALE
Ages:
Between 14 years and 45 years
Trial Updated:
08/19/2024
Locations: Kaufmann Medical Building, Pittsburgh, Pennsylvania
Conditions: Epilepsy, Pregnancy Related
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Genetic Markers of Cardiovascular Disease in Epilepsy
NCT02824822
Recruiting
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/13/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
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Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients
NCT00195052
Recruiting
The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging. The investigators propose that the ability to optically monitor neuronal activity in a large area of cortex in "real-time" will be a more sensitive and time-saving method than the electrical methods currently available. The applications of this technique will not only theoretically increase the safety and efficacy of many of neurosu... Read More
Gender:
ALL
Ages:
Between 6 years and 65 years
Trial Updated:
07/22/2024
Locations: Weill Cornell Medical College/New York Presbyterian Hospital, New York, New York
Conditions: Epilepsy
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Safety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT06352372
Recruiting
For this study, the proposed intervention will be noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM) - to the brains of autistic children. This will occur, twice a week, for 10 weeks. The NIR light is delivered to specific brain areas by Cognilum, a wearable device developed by Jelikalite. The expected outcome is improved focus, improved eye contact, improved speech, improved behavior, and gains in functional skills. Cognilum may impact the clinical pract... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
07/08/2024
Locations: Rossignol Medical Center, Phoenix, Arizona
Conditions: Autism Spectrum Disorder, EEG With Periodic Abnormalities, Epilepsy, Neurodevelopmental Disorders, Neurological Disorder
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The Neural Code and Dynamics of the Reading Network.
NCT05989893
Recruiting
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional significance to each region involved in cognitive processes as detected by cortical stimulation mapping (CSM) in patients with implanted subdural electrodes (SDE) or depth (sEEG) electrodes, to describe the lo... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/27/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy, Brain Tumor
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Computational Neuroscience of Language Processing in the Human Brain
NCT05222594
Recruiting
Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Language, Epilepsy
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Intracranial Stimulation Mapping In Epilepsy
NCT05290610
Recruiting
This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Epilepsy
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De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information
NCT05140265
Recruiting
This proposal outlines the steps required for the creation of a pilot database of EEG recordings and de-identified medical records from patients internally referred within the UNMH Comprehensive Epilepsy Center. The UNMH EEG Corpus would be the first database of its kind. Other public databases contain either patient EEG signals or medical records, but without both kinds of information, it is impossible to relate pre-treatment neurobiomarkers with post-treatment prognosis. The database will also... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2024
Locations: University of New Mexico Health Science, Albuquerque, New Mexico
Conditions: Epilepsy, Status Epilepticus, Seizures
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