There are currently 78 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Autism participants are Florida, California, Texas and New York.
Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients
NCT00195052
Recruiting
The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging. The investigators propose that the ability to optically monitor neuronal activity in a large area of cortex in "real-time" will be a more sensitive and time-saving method than the electrical methods currently available. The applications of this technique will not only theoretically increase the safety and efficacy of many of neurosu... Read More
Gender:
All
Ages:
Between 6 years and 65 years
Trial Updated:
08/17/2023
Locations: Weill Cornell Medical College/New York Presbyterian Hospital, New York, New York
Conditions: Epilepsy
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Physiological Brain Atlas Development
NCT00575081
Recruiting
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Gender:
All
Ages:
Between 6 years and 90 years
Trial Updated:
08/09/2023
Locations: Vanderbilt Univeristy, Nashville, Tennessee
Conditions: Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor, Epilepsy
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Neonatal Seizure Registry - Developmental Functional EValuation
NCT04337697
Recruiting
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities and whether these are modified by parent well-being.
Gender:
All
Ages:
Between 2 years and 8 years
Trial Updated:
08/08/2023
Locations: University of California, San Francisco, San Francisco, California +8 locations
Conditions: Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages, Epilepsy, Cerebral Palsy, Intellectual Disability
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VNS Prospective Neuromodulation of Autonomic, Immune and Gastrointestinal Systems
NCT03953768
Recruiting
Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of efficacy is not well understood; however it is increasingly recognized that electrical stimulation of the vagus nerve may impact other organ systems in the body including the immune, gastrointestinal and auton... Read More
Gender:
All
Ages:
Between 0 years and 60 years
Trial Updated:
08/04/2023
Locations: Norton Healthcare, Louisville, Kentucky +1 locations
Conditions: Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
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The Neural Code and Dynamics of the Reading Network.
NCT05989893
Recruiting
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional significance to each region involved in cognitive processes as detected by cortical stimulation mapping (CSM) in patients with implanted subdural electrodes (SDE) or depth (sEEG) electrodes, to describe the lo... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/04/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy, Brain Tumor
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Genetic Markers of Cardiovascular Disease in Epilepsy
NCT02824822
Recruiting
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
08/01/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
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Carbon Dioxide (CO2) Chemosensitivity and SUDEP
NCT04134754
Recruiting
The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or s... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
07/24/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Epilepsy, SUDEP
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Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
NCT04770337
Recruiting
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse even... Read More
Gender:
All
Ages:
9 years and above
Trial Updated:
07/21/2023
Locations: Barrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix, Arizona +28 locations
Conditions: Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures, Epilepsy in Children, Epilepsy, Epilepsy, Tonic-Clonic
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Understanding Ketamine's Dissociative Effects (KD Study)
NCT04861051
Recruiting
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Epilepsy
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Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
NCT05418894
Recruiting
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform with invasive intracranial recording electrodes provides much-needed spatial and temporal resolution to characterize the neural dynamics of socio-affective processing. The investigators will leverage... Read More
Gender:
All
Ages:
Between 22 years and 70 years
Trial Updated:
07/11/2023
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Treatment Resistant Depression, Epilepsy
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Human Intracranial Electrophysiology
NCT05529264
Recruiting
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/11/2023
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Epilepsy
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Telephone-Based Support Programs for People With Epilepsy
NCT05082181
Recruiting
This is a two-arm randomized controlled trial to compare telephone-based depression self-management (UPLIFT) to telephone-based support groups (BOOST). A sample of 120 English- and Spanish-speaking people with epilepsy (PWE) with elevated depressive symptoms will be enrolled. Both interventions are 8-week programs delivered in one-hour weekly sessions to groups of about 6 participants. Changes in depressive symptoms, quality of life and seizures will be assessed over 12 months. The trial will al... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
07/06/2023
Locations: NYU Langone Health, New York, New York
Conditions: Epilepsy
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