There are currently 76 active clinical trials seeking participants for Epilepsy research studies. The states with the highest number of trials for Epilepsy participants are Florida, California, Texas and New York.
VNS Prospective Neuromodulation of Autonomic, Immune and Gastrointestinal Systems
NCT03953768
Recruiting
Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of efficacy is not well understood; however it is increasingly recognized that electrical stimulation of the vagus nerve may impact other organ systems in the body including the immune, gastrointestinal and auton... Read More
Gender:
All
Ages:
Between 0 years and 60 years
Trial Updated:
08/04/2023
Locations: Norton Healthcare, Louisville, Kentucky +1 locations
Conditions: Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
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Genetic Markers of Cardiovascular Disease in Epilepsy
NCT02824822
Recruiting
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
08/01/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy, Seizures, Syncope, Channelopathy, Cardiomyopathies
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Carbon Dioxide (CO2) Chemosensitivity and SUDEP
NCT04134754
Recruiting
The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or s... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
07/24/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Epilepsy, SUDEP
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Understanding Ketamine's Dissociative Effects (KD Study)
NCT04861051
Recruiting
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Stanford University School of Medicine, Palo Alto, California
Conditions: Epilepsy
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Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
NCT05418894
Recruiting
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform with invasive intracranial recording electrodes provides much-needed spatial and temporal resolution to characterize the neural dynamics of socio-affective processing. The investigators will leverage... Read More
Gender:
All
Ages:
Between 22 years and 70 years
Trial Updated:
07/11/2023
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Treatment Resistant Depression, Epilepsy
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Human Intracranial Electrophysiology
NCT05529264
Recruiting
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/11/2023
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Epilepsy
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Sleep Spindles and Memory in Rolandic Epilepsy
NCT04569708
Recruiting
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Gender:
All
Ages:
Between 4 years and 18 years
Trial Updated:
06/01/2023
Locations: Athinoula A. Martinos Center Biomedical Imaging, Charlestown, Massachusetts
Conditions: Rolandic Epilepsy, Rolandic Epilepsy, Benign, Centrotemporal Epilepsy, Centrotemporal; EEG Spikes, Epilepsy of Childhood, Epilepsy; Seizure, Epilepsy
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Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
NCT04677751
Recruiting
The purpose of this study is to determine effects of Acupuncture on a Patient's mood and cognition,evaluate changes in clinically-reported seizure frequency and severity and analyze effects of Acupuncture on electrographic epileptiform activity stored by the RNS System
Gender:
All
Ages:
Between 15 years and 60 years
Trial Updated:
02/14/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy
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EpiCare@Home Validation Study for Focal Onset Seizures
NCT05738226
Recruiting
The goal of this clinical trial is to validate a wearable seizure monitoring device, EpiCare@Home, as an objective seizure monitoring tool for people with focal onset epileptic seizures. The device continuously records brain, cardiorespiratory, and physical activity data. The study aims to 1) collect benchmark data for seizure detection algorithm development and validation, and 2) evaluate the performance of the device in clinical and at home workflows. Participants will wear the device during... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
02/10/2023
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Epilepsy, Seizures, Seizures, Focal, Seizure, Refractory
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MR-Guided Focused Ultrasound in the Treatment of Focal Epilepsy (EP001)
NCT02804230
Recruiting
The purpose of this study is to evaluate the feasibility, safety, and initial effectiveness of Exablate thermal ablation of a focal epileptic target area in the brain of patients suffering from medication-refractory epilepsy, using the Exablate transcranial system to produce multiple sonications targeted in the focus of interest. The investigators will establish the feasibility and collect data to establish the basic safety of this type of treatment as the basis for later studies that will evalu... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
09/07/2022
Locations: Stanford University, Stanford, California +3 locations
Conditions: Epilepsy
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Cortical Excitability in Post-traumatic Epilepsy
NCT05517954
Recruiting
To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether such measures can be used to distinguish patients with post-traumatic epilepsy from patients with head trauma but no epilepsy
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
08/25/2022
Locations: Mid-Atlantic Epilepsy and Sleep center, Bethesda, Maryland
Conditions: Traumatic Brain Injury, Cortical Excitability, Epilepsy
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Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy
NCT05512130
Recruiting
About 30% of persons with epilepsy have seizures that do not respond to drugs. The ketogenic diet is an effective treatment option for them, but this high fat diet is strict and difficult to maintain. The properties of gliflozins, which often are used to treat type 2 diabetes, make them a potential replacement for the ketogenic diet. This pilot study will determine whether gliflozins induce ketosis and could be used to treat adults with epilepsy safely.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
08/20/2022
Locations: Washington University, Saint Louis, Missouri
Conditions: Epilepsy
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