Connecticut is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH
NCT02530073
Recruiting
The rationale for fetal therapy in severe congenital diaphragmatic hernia (CDH) is to restore adequate lung growth for neonatal survival.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Connecticut Children's Medical Center, Hartford, Connecticut
Conditions: Congenital Diaphragmatic Hernias
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The Dragon PLC Trial (DRAGON-PLC)
NCT06914648
Recruiting
The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable primary liver cancer compared to standard PVE alone. This trial specifically focuses on patients with hepatocellular carcinoma and cholangiocarcinoma. The main questions this trial aims to answer are whether combined PVE and HVE increases the proportion of patients who be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Yale School of Medicine Hospital, New Haven, Connecticut
Conditions: Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
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Effects of Cervical Manipulation on Cervical Rotation Motion and Shoulder Rotational Motion and Strength in Overhead Athletes
NCT06903793
Recruiting
This study will examine the effects of a single session of a quick stretch technique delivered to the neck on neck and shoulder motion as well as shoulder strength in collegiate overhead athletes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Sacred Heart University, Fairfield, Connecticut
Conditions: Cervical Spine, Manipulation, Spinal, Shoulder, Overhead Athlete
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Behavior Therapy for Irritability in Autism
NCT04654260
Recruiting
This is a clinical trial of a novel intervention, Behavioral Therapy for Irritability and Aggression (BTIA), for adolescents on the autism spectrum. The main goals of BTIA are to help adolescents develop emotion regulation skills to handle frustration and to strengthen skills for navigating the challenging and diverse experiences associated with the transition to adulthood. The study will test whether BTIA can be helpful to adolescents on the autism spectrum and to their families.
Gender:
ALL
Ages:
Between 12 years and 19 years
Trial Updated:
05/12/2025
Locations: Yale Child Study Center, New Haven, Connecticut
Conditions: Autism Spectrum Disorder, Irritability, Disruptive Behavior, Anger, Aggression, Asperger Syndrome, Pervasive Developmental Disorder
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S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer
NCT03418961
Recruiting
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Middlesex Hospital, Middletown, Connecticut
Conditions: Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7
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Reversal of Lipid-Induced Insulin Resistance
NCT02193295
Recruiting
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/12/2025
Locations: Magnetic Resonance Research Center (MRRC), New Haven, Connecticut
Conditions: Insulin Resistance, NAFLD
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A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of ANX007 in Participants With Geographic Atrophy (GA)
NCT06510816
Recruiting
The primary purpose of the study is to determine if IVT injections of ANX007 every month reduce vision loss in participants with GA secondary to age-related macular degeneration (AMD).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/08/2025
Locations: Retina Consultants, P.C., Manchester, Connecticut
Conditions: Geographic Atrophy
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Synchronous vs Asynchronous Remotely Delivered Lifestyle Interventions
NCT06393725
Recruiting
The goal of this clinical trial is to learn if a group-based digital weight loss program that is delivered asynchronously (via an online platform) is as effective as one that is delivered synchronously (via weekly videoconference meetings). In the asynchronous condition, participants can engage with their group any time 24/7. In the synchronous condition, participants can engage with their group once a week at a videoconference meeting. The main questions it aims to answer are: Will participant... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/08/2025
Locations: University of Connecticut, Storrs, Connecticut
Conditions: Obesity
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The Percutaneous Transmural Arterial Bypass -1 Study (Post Approval Registry)
NCT06315023
Recruiting
The purpose of this post-market surveillance study will be to evaluate the real-world use of the DETOUR System in treated patients with symptomatic femoropopliteal lesions from 200 mm to 460 mm in length with chronic total occlusions (100 mm to 425 mm) or diffuse stenosis \> 70% who may be considered suboptimal candidates for surgical or alternative endovascular treatments.
Gender:
ALL
Ages:
All
Trial Updated:
05/08/2025
Locations: University of Connecticut, Storrs, Connecticut
Conditions: Peripheral Arterial Disease, Symptomatic Femoropopliteal Lesions
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Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life
NCT06163469
Recruiting
The goal of this clinical trial is to evaluate the feasibility and tolerability of 0.05% Chlorhexidine Gluconate (CGH) bladder instillations in an outpatient setting at the time of suprapubic catheter (SPC) exchange in patients with history of recurrent urinary tract infections (UTI). The main questions are: 1. is instillation of 150mL of CGH for five-minute duration at the time of SPC exchange feasible in an outpatient setting and tolerable for patients. 2. does this protocol decrease the rate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: Yale New Haven Health, New Haven, Connecticut
Conditions: Neurogenic Bladder, Urinary Retention
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A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
NCT06132893
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/07/2025
Locations: Yale School of Medicine - Yale-New Haven Hospital, New Haven, Connecticut
Conditions: Focal Epilepsy
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Comparison of Uncomplicated Candidemia Therapy Duration in Children
NCT05763251
Recruiting
The goal of this clinical trial is to compare antifungal therapy duration in pediatric uncomplicated candidemia. The specific aims are: * Compare the desirability of outcome ranking in children with uncomplicated candidemia randomized to 7 additional days of antifungal therapy (standard-course) versus no additional antifungal therapy (short-course) after already receiving 7 days of echinocandin therapy. * Compare the 14-day desirability of outcome measure for subjects with a negative and those... Read More
Gender:
ALL
Ages:
Between 120 days and 18 years
Trial Updated:
05/07/2025
Locations: Yale New Haven Children's Hospital, New Haven, Connecticut
Conditions: Invasive Candidiasis
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