Connecticut is currently home to 1213 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Phase 1 Trial in Patients With Human Papillomavirus (HPV)-Associated Cancer
NCT05826275
Recruiting
This is an open-label, non-randomized, Phase I, dose escalation/dose expansion study in cohorts of patients with relapsed, resistant, or metastatic HPV-associated cancers. The Expansion Phase will begin in parallel one dose level lower than the highest dose deemed safe in the Dose Escalation in combination with a PD-1 checkpoint blockade.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: Yale University, New Haven, Connecticut
Conditions: HPV Associated Cancers
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Normative Database and Test-Retest Reliability for BrainCheck Assessments
NCT05497427
Recruiting
The purpose of this study is to collect normative test values and demographic information for normative and referential data for a rapid, portable, computerized neurocognitive testing device from healthy adults 50 and older.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/07/2024
Locations: Maplewood Senior Living, Multiple Locations, Connecticut
Conditions: Cognitive Change, Cognitive Decline, Cognitive Deterioration, Neurocognitive Deficit
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A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer
NCT02138734
Recruiting
This is a Phase Ib/IIb, randomized, two-cohort, open-label, multicenter study of intravesical N-803 plus BCG versus BCG alone, in BCG naïve patients with high-grade NMIBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: Eastern Connecticut Hematology & Oncology Associates, Norwich, Connecticut
Conditions: Non-muscle Invasive Bladder Cancer
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Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
NCT06371404
Recruiting
The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurrent PTSD and AUD with control groups. While there are a large number of studies conducted in preclinical stress and addiction models, these findings have not been translated to people living with these... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
08/06/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Alcohol Use Disorder, Post Traumatic Stress Disorder
Register for Updates
Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
NCT05808634
Recruiting
The objective of this study is to assess safety and efficacy of BA3182 in Advanced Adenocarcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Advanced Adenocarcinoma
Register for Updates
ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: Danbury Hospital, Danbury, Connecticut
Conditions: Ulcerative Colitis
Register for Updates
Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance
NCT03756480
Recruiting
This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/06/2024
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Endometriosis, Endometrial Diseases
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Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL
NCT04747236
Recruiting
The purpose of this study is to find out whether the combination treatment of romidepsin and oral azacytidine is safe and effective in patients with Peripheral T-Cell Lymphoma (PTCL). This study will compare the experimental combination treatment of romidepsin and oral azacytidine to single agent drugs already determined effective in patients with PTCL. For the purposes of this study, the single agent drugs already used to treat lymphoma are called investigator's choice (IC), meaning the investi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: PTCL
Register for Updates
DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma
NCT04696029
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
08/02/2024
Locations: Connecticut Children's Hospital, Hartford, Connecticut
Conditions: Medulloblastoma
Register for Updates
Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
NCT04301843
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.
Gender:
ALL
Ages:
31 years and below
Trial Updated:
08/02/2024
Locations: Connecticut Children's Hospital, Hartford, Connecticut
Conditions: Neuroblastoma
Register for Updates
Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer
NCT03383094
Recruiting
The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/02/2024
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Head and Neck Squamous Cell Carcinoma, Cancer, Cancer of Head and Neck, Cancer, Advanced, Cancer, Metastatic, Tumor, Tumor Recurrence, Tumor Neck, Tumor Metastasis, Oral Cancer, Oropharyngeal Cancer, Oropharynx Cancer, Oropharynx Cancer, Stage III, Oropharynx Cancer, Recurrent, Oropharynx Cancer, Metastatic
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Systems Investigation of Vaccine Responses in Aging and Frailty
NCT05291676
Recruiting
This study will compare the immune response signatures (including immunologic, transcriptomic and metabolomic) of the two influenza vaccines approved for use in adults age 65 and over (Fluad and Fluzone High-Dose).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
08/01/2024
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Influenza
Register for Updates