There are currently 693 clinical trials in Orlando, Florida looking for participants to engage in research studies. Trials are conducted at various facilities, including AdventHealth Orlando, GSK Investigational Site, Orlando Clinical Research Center and Nemours Children's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol
NCT06360419
Recruiting
PARADIGM (Progressing TAAR-1, Dopamine, and Norepinephrine in Depression Using Solriamfetol) is a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to assess the safety and efficacy of solriamfetol for the treatment of major depressive disorder (MDD) in adults.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/08/2024
Locations: Clinical Research Site, Orlando, Florida +2 locations
Conditions: Major Depressive Disorder
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Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
NCT03645928
Recruiting
A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL LN-144 (Lifileucel)/LN-145 in combination with checkpoint inhibitors or TIL LN-144 (Lifileucel)/LN-145/LN-145-S1 as a single agent therapy.
Gender:
All
Ages:
12 years and above
Trial Updated:
04/04/2024
Locations: Orlando Health Cancer Institute, Orlando, Florida
Conditions: Metastatic Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-small Cell Lung Cancer
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Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening
NCT04968548
Recruiting
This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
03/28/2024
Locations: Orlando Health, Inc., Orlando, Florida
Conditions: Lung Cancer
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EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
NCT06340620
Recruiting
This is a randomized trial to compare the standard echoendoscope with the newly developed EndoSound Visual System in the evaluation of lesions in the gastrointestinal tract.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
03/25/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Pancreatic Disease, Pancreatic Cancer, Pancreatic Cyst, Gastrointestinal Tumor, Bile Duct Diseases, Bile Duct Cancer, Lymph Node Disease, Submucosal Tumor of Gastrointestinal Tract, Gastrointestinal Cancer
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Evaluation of the PrevisEA Device for Predicting Gastrointestinal Impairment
NCT04880473
Recruiting
PrevisEA is a noninvasive, disposable device that uses audio spectral analysis of sounds produced by the gastrointestinal tract to predict gastrointestinal impairment (GII). GII is most commonly associated with postoperative ileus (POI), but could be the result of other causes, such as early postoperative bowel obstruction. GII is defined as failure of successful early oral re-feeding in a subject undergoing major abdominal surgery. For subjects who are allowed to resume a diet during the first... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
03/11/2024
Locations: Adventist Health System/Sunbelt, Inc. d/b/a AdventHealth Orlando, Orlando, Florida
Conditions: Gastrointestinal Complication
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Comparing Endoscopic Ultrasound vs Surgical Gastrojejunostomy for Management of GOO.
NCT06128018
Recruiting
The goal of this interventional study is to learn about the outcomes between two options for the management of malignant gastric outlet obstruction.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: AdventHealth Orlando, Orlando, Florida
Conditions: Malignant Gastric Outlet Obstruction
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ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies
NCT05653271
Recruiting
ACE1831 is an off-the-shelf, allogeneic gamma delta T (gdT) cell therapy derived from healthy donors, that is under investigation for the treatment of CD20-expressing B-cell malignancies. The ACE1831-001 study is an open-label, Phase I, first-in-human (FIH) study that aims to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and efficacy of ACE1831 in patients with CD20-expressing Non-Hodgkin lymphoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: AdventHealth Orlando, Orlando, Florida
Conditions: B-cell Lymphoma, Non Hodgkin Lymphoma, DLBCL, Primary Mediastinal Large B Cell Lymphoma, Marginal Zone Lymphoma, Follicular Lymphoma
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Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure ( BETA )
NCT06007131
Recruiting
The primary purpose for this study is to support the hypothesis (pilot data) that the use of the CPM system reduces the rate of HF related events and the related healthcare cost. The study will also measure the impact on quality of care and patient satisfaction. In order to support the primary objective, the study will compare the outcomes and costs for patients using the CPM system against those who are not. This can either be done using institutions averages, if available, or through a control... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Heart Failure
Register for Updates
Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure
NCT05650541
Recruiting
The primary purpose for this study is to support the hypothesis (pilot data) that the use of the CPM system reduces the rate of HF related events and the related healthcare cost. The study will also measure the impact on quality of care and patient satisfaction. In order to support the primary objective, the study will compare the outcomes and costs for patients using the CPM system against those who are not. This can either be done using institutions averages, if available, or through a control... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Heart Failure
Register for Updates
The Influence of Oral Contraceptives During Disuse
NCT06275048
Recruiting
Studies across various sports and physical activities have consistently shown that females incur more injuries compared to their male counterparts, but the underlying reasons for this disparity remain poorly understood. While differences in hormone levels between males and females have been speculated to play a role, very little rigorous research has been conducted to directly examine potential connections between sex hormones and injury risk. Specifically, females have been shown to be at great... Read More
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
02/16/2024
Locations: University of Central Florida, Orlando, Florida
Conditions: Oral Contraceptives, Rehabilitation, Menstrual Cycle, Physical Therapy
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Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
NCT06179459
Recruiting
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant morbidity and mortality, including significant abdominal pain, gastric outlet obstruction, biliary obstruction, organ failure, persistent unwellness, infection and sepsis. Symptomatic pancreatic fluid collections require treatment, and endoscopic drainage is considered... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
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Rectal Indomethacin to Prevent Acute Pancreatitis in EUS-FNA of Pancreatic Cysts
NCT05572788
Recruiting
The aim of this randomized trial is to compare the rate of post-procedure pancreatitis in patients undergoing EUS-FNA of pancreatic cysts; patients will receive either a single dose of indomethacin or placebo administered rectally, during EUS-FNA.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Orlando Health, Orlando, Florida
Conditions: Pancreatic Cyst, Pancreatitis, Acute
Register for Updates