The state of Florida currently has 45 active clinical trials seeking participants for Parkinson's Disease research studies. These trials are conducted in various cities, including Miami, Tampa, Jacksonville and Orlando.
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
NCT06285643
Recruiting
The objective of this randomized, surgically controlled, double-blinded, Phase 2 study is to evaluate the safety and efficacy of AAV2-GDNF delivered to the putamen in subjects with moderate Parkinson's Disease.
Gender:
All
Ages:
Between 45 years and 75 years
Trial Updated:
06/20/2024
Locations: Parkinson's Disease Treatment Center of Southwest Florida, Port Charlotte, Florida
Conditions: Parkinson Disease
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Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)
NCT04127578
Recruiting
Study J3Z-MC-OJAA is a Phase 1/2a, multicenter, open-label, ascending dose, first in-human study that will evaluate the safety of intracisternal LY3884961 administration in patients with moderate to severe Parkinson's disease with at least 1 pathogenic GBA1 mutation. Two dose level cohorts of LY3884961 are planned (Dose Level 1 and Dose Level 2). The duration of the study is 5 years. During the first year, patients will be evaluated for the effect of LY3884961 on safety, tolerability, immunogeni... Read More
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
06/18/2024
Locations: K2 Medical Research, 101 Southhall Lane, Suite 150, Maitland, Florida +1 locations
Conditions: Parkinson Disease
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Parkinson's Disease Progression Study
NCT06219629
Recruiting
Disease Progression Study
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/18/2024
Locations: Parkinsons Disease And Movement Disorders Center Of Boca Raton, Boca Raton, Florida +3 locations
Conditions: Parkinson Disease
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Physiology, Imaging and Modeling of Essential Tremor
NCT03811405
Recruiting
This project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices. The study team aims to investigate safety and efficacy of these new stimulation parameters in patients with ET.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
06/17/2024
Locations: UF Health at the University of Florida, Gainesville, Florida +1 locations
Conditions: Essential Tremor, Parkinson Disease, Dystonia
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Use of CereGate Therapy for Freezing of Gait in PD
NCT05292794
Recruiting
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
Gender:
All
Ages:
Between 21 years and 75 years
Trial Updated:
06/14/2024
Locations: University of Miami, Miami, Florida
Conditions: Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
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Visualization of the STN and GPi for DBS
NCT05774041
Recruiting
The purpose of the study is to determine if using SIS System for DBS planning results in less distance between the planned target location and the actual implanted lead location than DBS planning without SIS System.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2024
Locations: University of Miami, Miami, Florida +1 locations
Conditions: Deep Brain Stimulation, Parkinson Disease
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A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of UCB0022 in Study Participants With Advanced Parkinson's Disease
NCT06055985
Recruiting
The primary purpose of this study is to demonstrate the superiority of UCB0022 as an adjunctive treatment to stable dose of standard-of-care (SoC) (including at least levodopa therapy) over placebo with regard to motor fluctuations time spent in the OFF state (OFF time) in study participants with advanced Parkinson's Disease (PD).
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
06/13/2024
Locations: Pd0060 50600, Altamonte Springs, Florida +15 locations
Conditions: Parkinson Disease
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Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
NCT02071134
Recruiting
The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific's commercially available Vercise DBS System in the treatment of Parkinson's disease. The utilization of Image Guided Programming (IGP), and other commercially available programming features, used as planning tools for the programming of patients with Boston Scientific's Vercise DBS System are also evaluated. Additionally, the utilization of the DBS Illumina 3D feature that may be... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: University of Florida Shands Hospital, Gainesville, Florida +4 locations
Conditions: Parkinson's Disease
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Deep Brain Stimulation (DBS) Retrospective Outcomes Study
NCT03664609
Recruiting
The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.
Gender:
All
Ages:
All
Trial Updated:
06/11/2024
Locations: University of Miami Hospital, Miami, Florida +1 locations
Conditions: Parkinson Disease, Essential Tremor, Dystonia
Register for Updates
A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease
NCT05924243
Recruiting
This is a multi-center, randomized, double blind, adaptive, parallel-group, placebo controlled Phase 1b study to evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics of RO7486967 in participants with idiopathic PD at the early stage of the disease (modified H&Y stage ≤2.5) who are either treatment-naïve or on stable treatment with symptomatic therapy (levodopa and/or pramipexole, ropinirole, rotigotine).
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
06/07/2024
Locations: Advent Health Orlando, Orlando, Florida
Conditions: Parkinson Disease
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STEM-Parkinson's Disease
NCT04797611
Recruiting
This is a double-blinded, controlled, randomized clinical trial (RCT) to establish the safety and efficacy of a non-invasive neuromodulation device for treating symptoms associated with Parkinson's disease.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/04/2024
Locations: Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida +2 locations
Conditions: Parkinson Disease, Parkinson's Disease and Parkinsonism
Register for Updates
Early Parkinson's Disease Monotherapy With CVN424
NCT06006247
Recruiting
This is a multicenter, 12-week, placebo-controlled clinical trial of CVN424 150 milligrams (mg) tablets in early, untreated Parkinson's Disease (PD). Participants will be randomized in a 1:1 ratio to CVN424 150 mg or placebo at the Baseline Visit. The purpose of this study is to measure effect on motor features with CVN424 tablets compared to placebo in early, untreated PD and to evaluate the potential of CVN424 to improve motor and non-motor functions in participants with early PD who are not t... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
06/04/2024
Locations: Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida +3 locations
Conditions: Parkinson's Disease
Register for Updates