Indiana is currently home to 1254 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
Recruiting
The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 [NCT05620823] or INCB 54707-302 [NCT05620836]).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Investigative Site US206, Indianapolis, Indiana
Conditions: Hidradenitis Suppurativa (HS)
Suction Cervical Stabilizer Compared to Standard Tenaculum for Intrauterine Procedures
Recruiting
To evaluate patient-reported pain, bleeding, and device efficiency along with provider satisfaction and ease of use between intrauterine procedures employing a suction cervical stabilizer (new device, FDA approved, atraumatic) or single-tooth tenaculum (standard, traumatic). This device, cleared by the FDA in 2023, was studied in Europe and showed pain reduced by up to 73% and bleeding reduced by 78% compared to the single-tooth tenaculum for intrauterine contraceptive device insertion. The inve... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Indiana University Hospital, Indianapolis, Indiana
Conditions: Intrauterine Device (IUD), Abnormal Uterine Bleeding
Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors
Recruiting
This phase II trial tests how well darolutamide in combination with leuprolide acetate and exemestane works in treating patients with ovarian granulosa cell tumors that have come back after a period of improvement (recurrent). Darolutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of tumor cells. Leuprolide acetate is in a class of medications called gonadotropin-relea... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Conditions: Adult Ovarian Granulosa Cell Tumor
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)
Recruiting
This study is being conducted to determine the efficacy and safety of povorcitinib in participants with nonsegmental vitiligo.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Indiana University School of Medicine Iusm Indianapolis, Indianapolis, Indiana
Conditions: NonSegmental Vitiligo
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)
Recruiting
This study is being conducted to determine the efficacy and safety of povorcitinib in participants with nonsegmental vitiligo.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Randall Dermatology, Kokomo, Indiana
Conditions: NonSegmental Vitiligo
Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis
Recruiting
A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of bexotegrast (PLN-74809) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF).
Gender:
All
Ages:
40 years and above
Trial Updated:
02/23/2024
Locations: IU Health Advanced Heart and Lung Care, Indianapolis, Indiana
Conditions: Idiopathic Pulmonary Fibrosis
A Study to Evaluate Efficacy and Safety of SAR441566 in Adults With Plaque Psoriasis
Recruiting
This is a Phase 2, international, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, 12-week study. It is designed to assess the therapeutic dose, efficacy, and safety of treatment with SAR441566 in male and female adults with moderate to severe plaque psoriasis. Study details include a screening period (4 weeks and not less than 11 days before Day 1), a treatment period (12 weeks ± 3 days) and a post-treatment period (safety follow-up) (2 weeks ± 3 days). The total number... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/23/2024
Locations: Dawes Fretzin Clinical Research Group, LLC Site Number : 8400008, Indianapolis, Indiana
Conditions: Psoriasis
Validation of Point-of-care Thromboelastography (TEG 6s) in Pediatric Patients
Recruiting
The goal of this observational study is to learn about the performance of the TEG6s in normal pediatric patients. The main questions it aims to answer are: What are the normal TEG 6S lab results in normal pediatric patients and how do they compare to existing published reference ranges. Participants and their guardians will be asked to submit a small amount of blood at the beginning of an elective operation for analysis in the TEG 6s machine.
Gender:
All
Ages:
Between 3 months and 18 years
Trial Updated:
02/23/2024
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Coagulopathy
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
Recruiting
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both. CD may be associated with abdominal cramps/pain, diarrhea, blood in the stool, weight loss, or delayed growth in children. While the exact cause of CD is not certain it is thought that the immune system located in the intestine reacts abnormally to the large number of bacteria contained there. The investigators think that diet, exposure to anti... Read More
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
02/23/2024
Locations: Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana
Conditions: Crohn Disease
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Recruiting
Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood. Symptoms can include swelling of the glands in the throat, mouth ulcers, and tonsillitis. Removal of the tonsils can stop the periodic flareups. But researchers do not know how PFAPA develops. In this natural history study, researchers will collect specimens and data from people with PFAPA to see what they might have in common. Objective: To coll... Read More
Gender:
All
Ages:
Between 1 month and 99 years
Trial Updated:
02/23/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis, Tonsil Disorder, Sleep Disordered Breathing
A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy
Recruiting
The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: IU Health Advanced Heart and Lung Care, Indianapolis, Indiana
Conditions: Cardiomyopathy, Hypertrophic
A Comparison of PT027 vs PT007 Used as Needed in Participants With Asthma
Recruiting
This is a US study comparing the efficacy and safety of BDA MDI [Budesonide/Albuterol Sulfate (BDA) metered dose inhaler (MDI)] with AS [Albuterol Sulfate] MDI, both are administered as needed for up to 12 months.
Gender:
All
Ages:
12 years and above
Trial Updated:
02/23/2024
Locations: Velocity Clinical Research - Valparaiso, Valparaiso, Indiana
Conditions: Asthma