Indiana is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
NCT01860612
Recruiting
The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects.
Gender:
All
Ages:
3 years and above
Trial Updated:
10/21/2022
Locations: Price Vision Group, Indianapolis, Indiana
Conditions: Full Aniridia, Partial Aniridia
Register for Updates
Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th Salvage
NCT03926624
Recruiting
Phase III, multicenter, randomized study with two arms (1:1 ratio) enrolling patients with AML relapsed/refractory after 2, 3, or 4 prior induction regimens: Experimental arm: DFP-10917 14-day continuous intravenous (IV) infusion at a dose of 6 mg/m²/day followed by a 14-day resting period per 28-day cycles. Control arm: Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High and Intermediate Dose Cytarabine Regimens), dependin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2022
Locations: Franciscan Health Indianapolis, Indianapolis, Indiana
Conditions: Leukemia, Myeloid, Acute
Register for Updates
Critical Health Assessment and Outcomes Score/Study
NCT02766166
Recruiting
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. By integrating approaches from the physical, biological, computational, statistical and clinical sciences, this observational study will test the hypothesis that early diagnosis of subclinical signatures of critical illness encoded within physiologi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/07/2022
Locations: Indiana University, Indianapolis, Indiana
Conditions: Critical Illness, Death, Sudden
Register for Updates
Surveillance AFter Extremity Tumor surgerY
NCT03944798
Recruiting
Following treatment for a primary extremity sarcoma, patients remain at risk for the development of local and systemic disease recurrence. Metastasis (distant recurrence) to the lung is the most frequent single location of disease recurrence in sarcoma patients, occurring in almost half of all patients. Therefore, careful post-operative surveillance is an integral element of patient care. However, the detection of metastases does not necessarily affect long-term survival and may negatively impac... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/04/2022
Locations: Parkview Cancer Institute, Fort Wayne, Indiana
Conditions: Soft Tissue Sarcoma, Lung Metastases
Register for Updates
Rare and Atypical Diabetes Network
NCT05544266
Recruiting
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical di... Read More
Gender:
All
Ages:
All
Trial Updated:
09/14/2022
Locations: Indiana University, Indianapolis, Indiana
Conditions: Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
Register for Updates
Leg Heat Therapy in Elderly Individuals
NCT05543980
Recruiting
The number of persons aged ≥60 years in the United States is expected to nearly double, from 57 to 109 million between 2010 and 2050. These demographic changes will have profound implications for the healthcare system because advanced age is associated with a heightened risk of negative health outcomes, including disability and frailty. Few therapeutic strategies currently exist to combat the age-related decline in physical functioning that stems from the progressive loss of muscle mass and stre... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
09/13/2022
Locations: Purdue University, West Lafayette, Indiana
Conditions: Aging, Muscle Weakness
Register for Updates
Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis
NCT04880187
Recruiting
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving fat and inflammation (steatohepatitis) as well as fibrosis in subjects with non alcoholic steatohepatitis (NASH). as well as the safety and tolerability of AXA1125. Subjects will take one of two different doses of AXA1125 or a placebo twice daily, and a liver biopsy will be done at the beginning and end of the 48-week study.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: ASHA Clinical Research, Hammond, Indiana
Conditions: Non Alcoholic Steatohepatitis (NASH)
Register for Updates
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
NCT04502394
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, combined with acalabrutinib for the treatment of adults with Diffuse Large B-Cell Lymphoma and Chronic Lymphocytic Leukemia. Participants must be relapsed/refractory (having failed prior therapy)
Gender:
All
Ages:
18 years and above
Trial Updated:
08/03/2022
Locations: Goshen Center for Cancer Care, Goshen, Indiana
Conditions: Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
Register for Updates
A Study to Monitor Ambulatory Blood Pressure Monitoring in Hypogonadal Men Treated With Nasal Testosterone Gel
NCT04976595
Recruiting
The purpose of this study is to assess the change in 24-hour ambulatory blood pressure monitoring (ABPM) between baseline (Day 0) and Day 120 following 4 months of testosterone therapy with Natesto.
Gender:
Male
Ages:
Between 18 years and 80 years
Trial Updated:
07/04/2022
Locations: Investigative Clinical Research of Indiana, Elwood, Indiana
Conditions: Hypogonadism
Register for Updates
Feasibility and Acceptability of Music Therapy for Chronic Pain
NCT05426941
Recruiting
The purpose of the study is to examine the feasibility and acceptability of two music interventions delivered through telehealth for chronic musculoskeletal pain. This pilot study evaluates outcomes (feasibility, acceptability, pain and associated outcomes) in a single-component, minimally interactive music listening (ML) intervention and a multi-component, more interactive music imagery (MI) intervention.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/28/2022
Locations: Roudebush VA Medical Center, Indianapolis, Indiana
Conditions: Chronic Pain
Register for Updates
Artisan Aphakia Lens for the Correction of Aphakia in Children
NCT01547442
Recruiting
The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
06/24/2022
Locations: Indiana University, Riley Hospital for Children, Indianapolis, Indiana
Conditions: Aphakia
Register for Updates
Artisan Aphakia Lens for the Correction of Aphakia (Secondary) in Adults
NCT01547429
Recruiting
This study will determine the safety and effectiveness of the Artisan Aphakia Lens when used as a secondary implant to correct aphakia in adults.
Gender:
All
Ages:
22 years and above
Trial Updated:
06/24/2022
Locations: Price Vision Group, Indianapolis, Indiana
Conditions: Aphakia
Register for Updates