Kentucky is currently home to 1106 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Continuous vs. Intermittent Infusion Vancomycin
NCT05823116
Recruiting
Hospitalized adult participants prescribed vancomycin by their treating physician will be randomized to receive vancomycin via continuous or intermittent infusion and measures of kidney function and injury will be collected.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Vancomycin
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Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
All
Ages:
All
Trial Updated:
05/26/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
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Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
NCT04600089
Recruiting
The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/25/2023
Locations: University of Kentucky Medical Center, Lexington, Kentucky
Conditions: Descending Aortic Dissection, Postoperative Pain, Thoracoabdominal Aortic Aneurysm
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Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
NCT05642572
Recruiting
This phase II Lung-MAP treatment trial test the combination of targeted drugs (capmatinib, osimertinib, and/or ramucirumab) in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and that has EGFR and MET gene changes. Capmatinib and osimertinib are in a class of medications called kinase inhibitors. They work by blocking the action of the abnormal protein that signals cancer cel... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2023
Locations: Flaget Memorial Hospital, Bardstown, Kentucky
Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Register for Updates
An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample
NCT04180930
Recruiting
Given the high prevalence of post-traumatic stress disorder (PTSD) in veterans and active duty military, the focus of this research study is to test the reliability of two new PTSD assessments, the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) and the PTSD Symptom Scale Interview for DSM-5 (PSSI-5) and compare the results between the two new assessments and the previous "gold standard", the Clinician Administered PTSD Scale for DSM-IV (CAPS-IV). Biomarkers believed to be related to PTSD (... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Cincinnati VA Medical Center - Trauma Recovery Center, Fort Thomas, Kentucky
Conditions: Stress Disorders, Post-Traumatic
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Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair
NCT03610763
Recruiting
This study adopts a strategy that has arisen from basic neuroscience research on facilitating adaptive brain plasticity and applies this to rehabilitation to improve functional recovery in peripheral nervous system injuries (including hand transplantation, hand replantation, and surgically repaired upper extremity nerve injuries). The technique involves combining behavioral training with transcranial direct current stimulation (tDCS)-a non-invasive form of brain stimulation capable of facilitati... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/12/2023
Locations: Christine Kleinert Institute for Hand & Microsurgery, Louisville, Kentucky
Conditions: Hand Transplantation, Peripheral Nerve Injuries, Neurologic Rehabilitation
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Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies
NCT05548413
Recruiting
People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them work together and build skills to overcome their individual barriers to adherence in order to 1) improve and sustain patient medication adherence; 2) reduce hospitalization; 3) improve quality of life. I... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2023
Locations: Jia-Rong Wu, Lexington, Kentucky
Conditions: Medication Adherence, Heart Failure
Register for Updates
ROSE-Longitudinal Assessment With Neuroimaging
NCT05089331
Recruiting
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2023
Locations: Baptist Health Louisville, Louisville, Kentucky
Conditions: Intracerebral Hemorrhage
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Personalized Treatment for Eating Disorders Versus CBT-E Trial
NCT05195840
Recruiting
The scientific premise, developed from past work, is that treatment personalized based on idiographic models (termed Network Informed Personalized Treatment; NA-PT) will outperform the current gold-standard treatment (Enhanced Cognitive Behavioral Therapy: CBT-E). The study goals are to (1) develop and test the acceptability, feasibility, and preliminary efficacy of a randomization of NA-PT versus CBT-E and (2) to test if network-identified precision targets are the mechanism of change. These go... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/10/2023
Locations: Eating Anxiety Treatment Laboratory and Clinic, Louisville, Kentucky
Conditions: Eating Disorders
Register for Updates
Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma
NCT04513028
Recruiting
The purpose of this study is to determine how beta-glucan affects the immune system in subjects with melanoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/10/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Melanoma Stage III, Melanoma Stage IV
Register for Updates
Effectiveness of a Multi-Level Smoking Cessation Program for High-Risk Women in Rural Communities
NCT04340531
Recruiting
This phase IV trial examines the effectiveness of a multi-level smoking cessation program for high-risk women in rural communities. Cigarette smoking is a major risk factor for cervical cancer in women. Rural primary care practices and providers often lack the electronic health record support to pre-identify smokers for services, as well as lack the necessary counseling training and access to comprehensive cessation programs. Implementing evidence-based smoking cessation programs in rural Appala... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
05/10/2023
Locations: University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Conditions: Tobacco-Related Carcinoma
Register for Updates
Endocrine Therapy Fulvestrant & Palbociclib or Aromatase Inhibitor Therapy in Treating Older Patients With Hormone Responsive Breast Cancer That Cannot Be Removed by Surgery
NCT02760030
Recruiting
This phase II clinical trial studies how well fulvestrant and palbociclib works in treating older patients with breast cancer that responds to hormone treatment (hormone responsive) that cannot be removed by surgery. Estrogen can cause the growth of estrogen-receptor-positive breast cancer cells. Hormone therapy using fulvestrant may fight estrogen-receptor-positive breast cancer by blocking the use of estrogen by the tumor cells. Palbociclib may stop the growth of tumor cells by blocking some o... Read More
Gender:
Female
Ages:
65 years and above
Trial Updated:
05/03/2023
Locations: St. Elizabeth Healthcare, Edgewood, Kentucky
Conditions: Estrogen Receptor and/or Progesterone Receptor Positive, HER2/Neu Negative, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
Register for Updates