Kentucky is currently home to 1068 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Louisville, Lexington, Owensboro and Paducah. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Hyperbaric Oxygen Brain Injury Treatment Trial
NCT02407028
Recruiting
The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent phase III trial.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
02/06/2024
Locations: University of Kentucky Hospital, Lexington, Kentucky
Conditions: Traumatic Brain Injury
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Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers
NCT01871454
Recruiting
The objective of this prospective phase II protocol is to assess the toxicity and efficacy of pentoxifylline and SABR in the re-treatment of recurrent or new lung cancers
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: James Graham Brown Cancer Center, U of Louisville, Louisville, Kentucky
Conditions: Non-small Cell Lung Cancers
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LE as a Marker for Periprosthetic Joint Infection
NCT05440032
Recruiting
Testing and comparison of a novel point-of-care electrochemical assay to detect and help diagnose periprosthetic joint infection on the hip and knee to the standard of care test
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Prosthetic-joint Infection
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: NASH - Nonalcoholic Steatohepatitis
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Study of Eblasakimab in Male or Female Moderate-to-Severe Atopic Dermatitis Patients Previously Treated With Dupilumab
NCT05694884
Recruiting
Multicenter, randomized, double-blind, placebo-controlled, parallel arm clinical study designed to evaluate the efficacy and safety of eblasakimab in participants with moderate-to-severe atopic dermatitis (AD) previously treated with dupilumab.The study consists of a 16-week treatment period and an 8-week follow-up period up to Week 24. Eligible participants will be randomized into one of the 2 treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: ASLAN Investigative Site, Louisville, Kentucky
Conditions: Atopic Dermatitis
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The Mobility Toolkit: Electronically Augmented Assessment of Functional Recovery Following Lower-extremity Trauma
NCT04047030
Recruiting
The study will prospectively enroll and follow 300 participants ages 18-60 surgically treated for a lower-extremity articular injury including fractures of the tibial plateau, pilon, ankle, and calcaneus.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
12/22/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Gait
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Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue
NCT01294072
Recruiting
This clinical trial will investigate the ability of plant exosomes to more effectively deliver curcumin to normal colon tissue and colon tumors. Curcumin is the yellow pigment of turmeric, a natural product with diverse biological activities. Exosomes are small endosome-derived vesicles (50-100 nanometers \[nm\] in size). Previous clinical trials conducted with oral curcumin have demonstrated only limited bioavailability even at very high doses of 8-12 grams per day. This trial plans to address... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
12/14/2023
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Colon Cancer
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Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
NCT05865041
Recruiting
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2023
Locations: 1 Site, Louisville, Kentucky
Conditions: Alopecia Areata
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Mobile Application-based Exercise Intervention for Pregnant Women
NCT05849649
Recruiting
The overarching goal of this randomized controlled clinical trial is to test the efficacy of the mHealth app (BumptUp) for improving physical activity levels among pregnant and postpartum women in a rural setting. Secondary outcomes include weight status, dietary intake, glucose tolerance, blood pressure, and mental health. Specific Aim 1. Conduct an RCT (N=176) to assess the efficacy of the mHealth intervention for increasing physical activity levels during pregnancy (13-15, 23-25, and 35-37 w... Read More
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
11/30/2023
Locations: Rachel Tinius, Bowling Green, Kentucky
Conditions: Pregnancy Related, Postpartum
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Improving Bowel Function and Quality of Life After Spinal Cord Injury
NCT03949660
Recruiting
Bowel dysfunction is consistently rated as one of the most common complications affecting daily life for individuals with spinal cord injury. The overall objective of this study is to investigate whether the use of specific spinal cord epidural stimulation will affect bowel function. This study will also examine how alterations in bowel function influence quality of life outcomes. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries tha... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/25/2023
Locations: Frazier Rehab Institute, Louisville, Kentucky
Conditions: Neurogenic Bowel
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Desara ® One Single Incision Sling 522 Study
NCT04772131
Recruiting
A post-market study to compare the safety and effectiveness of the Desara® One Single Incision Sling (SIS), when compared to that of an FDA cleared transobturator sling over a period of 36 months.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Stress Urinary Incontinence
Register for Updates
LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC
NCT04759664
Recruiting
The study evaluates the efficacy and safety of two strengths of LUT014 Gel topically applied once a day for 4 weeks, compared to placebo, in metastatic colorectal cancer (mCRC) patients who developed Grade 2 or non-infected Grade 3 EGFRI induced acneiform lesions
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/05/2023
Locations: Appalachian Regional Healthcare, Hazard, Kentucky
Conditions: EGFRI Induced Acneiform Lesions
Register for Updates