There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
NCT04735263
Recruiting
interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
Gender:
All
Ages:
Between 50 years and 85 years
Trial Updated:
10/07/2021
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Age-related Macular Degeneration
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A Study of MPT-0118 in Subjects With Advanced or Metastatic Refractory Solid Tumors
NCT04859777
Recruiting
This is a Phase 1/1b open-label, dose-escalation, and cohort expansion study with BID (tablet) oral dose of MPT-0118 in subjects with advanced or metastatic refractory solid tumors. The study will be conducted in 3 parts: Part A: MPT-0118 dose-escalation Part B: MPT-0118 dose-escalation in combination with pembrolizumab Part C: Cohort expansion of MPT-0118 in combination with pembrolizumab
Gender:
All
Ages:
18 years and above
Trial Updated:
09/15/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Solid Tumor, Adult, Advanced Solid Tumor, Advanced Cancer, Metastatic Cancer, Refractory Cancer
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Myeloma-Developing Regimens Using Genomics (MyDRUG)
NCT03732703
Recruiting
The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to uncontrolled cell growth and cancer. Patients with a greater than 25% mutation to any of the following genes; CDKN2C, FGFR3, KRAS, NRAS, BRAF V600E, IDH2 or T(11;14) can be enrolled to one of the treatment arms. These arms have treatments specifically directed to the mutated genes. Patients that do not have a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/09/2021
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts +2 locations
Conditions: Relapsed Refractory Multiple Myeloma
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Resiliency Training in Adolescents With NF1 and NF2
NCT03873610
Recruiting
This randomized controlled trial for resiliency training in adolescents with Neurofibromatosis 1 and Neurofibromatosis 2 via secure live video to determine the efficacy two stress and symptom management programs. Both programs are 8 week group programs.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
09/07/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neurofibromatoses
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Management of Esophagitis Following Repair of Esophageal Atresia
NCT03619408
Recruiting
The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia. Recent clinical guidelines have attempted to define a systematic approach to the management of these patients with regards to minimizing and treating esophagitis (Krishnan et al 2016), however the quality of evidence supporting many of the recommendations are based on expert opinion or on limited, retrospective studies. Risk factors for esophagitis and op... Read More
Gender:
All
Ages:
Between 30 days and 17 years
Trial Updated:
09/02/2021
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Esophageal Atresia, Esophagitis
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GARNET™ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection
NCT04658017
Recruiting
To evaluate the feasibility of performing combined hemodialysis with the GARNET device in chronic hemodialysis patients with a blood stream infection (BSI), and measure clinical performance and safety endpoints.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
09/01/2021
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Bloodstream Infection
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Identification/Characterization of Changes in Microscopic Colitis
NCT03063957
Recruiting
The goal of this study is to establish a prospective observational cohort of adult patients with microscopic colitis and collect clinical information and specimens over the course of their treatment. This information will be used in order to establish a patient registry with detailed clinical data and a specimen repository for future research as well as to specifically identify genetic and molecular characteristics associated with microscopic colitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/31/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Colitis, Microscopic
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Blood Transfusion by Boston MedFlight Registry
NCT04610814
Recruiting
The primary aim of this observational registry is to study the outcomes of patients with hemorrhagic shock transported by Boston MedFlight receiving blood products during transport.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/30/2021
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hemorrhagic Shock
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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
All
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts +1 locations
Conditions: B-cell Acute Lymphoblastic Leukemia
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Optimization of Diet Before Surgery (OptiSurg)
NCT04627688
Recruiting
The overarching goal of this project is to assess whether a controlled short-term Time restricted feeding (TRF) intervention leads to metabolic benefits, improves recovery after vascular surgery and that TRF is safe. Participants suffering from intermittent claudication (Fontaine stage II peripheral artery disease, PAD) will be randomly assigned to a 2-week TRF or active control dietary advices before open surgical revascularization. Prior to the surgery, the investigators will assess the eating... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Surgery, Time Restricted Feeding
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Novel Assessment of Synaptic Density in Progressive MS
NCT04634994
Recruiting
The investigators propose to use the novel SV2a-PET ligand, [F-18]SDM-8 to assess synaptic density in progressive MS (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)) as compared to relapsing-remitting multiple sclerosis (RRMS) patients and healthy controls, given its improved imaging characteristics and potential for large scale applicability. The specific aims of the study are: Aim 1: To compare the cortical and subcortical grey mat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
07/20/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Relapsing Multiple Sclerosis, Multiple Sclerosis
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Apple Heart & Movement Study
NCT04198194
Recruiting
This study will look for factors that affect heart health and potentially cause deterioration in mobility or heart function. Participant's Apple Watch and iPhone can help researchers gain a better understanding of potential early warning signs. This can lead to new interventions and products that will help millions lead longer, healthier, and more active lives.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Prevention
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