Ohio is currently home to 3322 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Prenatal Genetic Diagnosis by Genomic Sequencing
NCT03936101
Recruiting
This study is evaluating the impact of prenatal sequencing on the management of fetuses with ultrasound abnormalities. The hypothesis is that a significant subset of fetal abnormalities have a genetic cause that can be identified by sequencing and that prenatal knowledge of this information will improve prenatal care, reduce unnecessary diagnostic testing, reduce the cost of care, and improve the quality of life for both the child and the family.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/20/2022
Locations: Children's Hospital, Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Fetal Structural Anomalies
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Natural History of Neuronal Ceroid Lipofuscinosis, Batten's CLN6 Diseae
NCT03285425
Recruiting
CLN6 is a rare, neurodegenerative disease that causes progressive loss of acquired skills with motor delay, visual loss, seizures and ataxia. The investigators propose a natural history study of this rare disorder since it is currently unknown. It is important to understand disease progression in CLN6 disease to be able to judge therapeutic efficacy as emerging therapies like gene therapy become available.
Gender:
All
Ages:
Between 2 years and 25 years
Trial Updated:
10/20/2022
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Batten Disease, CLN6
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CERENOVUS Neurothrombectomy Devices Registry
NCT05591183
Recruiting
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Cerebral Stroke
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Real World Treatment Experience of Patients With Breast, Lung, or GI Cancer or Multiple Myeloma Using Remote Symptom Monitoring
NCT05587972
Recruiting
The Carevive registry collects patient characteristics, patient symptoms, and treatment experience data from patients receiving cancer treatment for breast, lung, GI or multiple myeloma. For this study, a core set of variables is collected on each patient in the Carevive platform. Patients will complete a baseline survey in person using a secured device or remotely using their own electronic device in a location of their choice. Weekly electronic Patient Reported Outcome surveys are collected fr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2022
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Breast Cancer, Lung Cancer, Gastrointestinal Cancer, Multiple Myeloma
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Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th Salvage
NCT03926624
Recruiting
Phase III, multicenter, randomized study with two arms (1:1 ratio) enrolling patients with AML relapsed/refractory after 2, 3, or 4 prior induction regimens: Experimental arm: DFP-10917 14-day continuous intravenous (IV) infusion at a dose of 6 mg/m²/day followed by a 14-day resting period per 28-day cycles. Control arm: Non-Intensive Reinduction (LoDAC, Azacitidine, Decitabine, Venetoclax Combination Regimens) or Intensive Reinduction (High and Intermediate Dose Cytarabine Regimens), dependin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2022
Locations: Gabrail Cancer Center, Canton, Ohio
Conditions: Leukemia, Myeloid, Acute
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Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers
NCT05586542
Recruiting
The goal of this clinical trial is to determine the safety of DERMASEAL for the treatment of non-healing, neuropathic diabetic foot ulcers. The main outcome measure is safety. A total of twenty-four (24) participants will be randomized to receive up to four (4) consecutive weeks of treatment with either standard of care (SOC), plasma film + SOC, or plasma film containing silver microparticles (DERMASEAL) + SOC, with a final follow-up visit 12 weeks after the last treatment.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/16/2022
Locations: Lower Extremity Institute for Research and Therapy, LLC, Boardman, Ohio
Conditions: Foot Ulcer, Diabetic
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Evaluating the Clinical Effectiveness of a Patient-specific Silicone Stent
NCT05050591
Recruiting
The goal of the trial is to establish a method, material, and patient-specific stent design that will last longer, fit better, and cause less trauma to the airway and the patient.
Gender:
All
Ages:
22 years and above
Trial Updated:
10/14/2022
Locations: Pulmonary Medicine, Cleveland, Ohio
Conditions: Pulmonary Disease, Chronic Obstructive
Register for Updates
A Gene Hunting Study for Familial Papillary Thyroid Cancer
NCT02776969
Recruiting
The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/13/2022
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Thyroid
Register for Updates
Phase 1 Open Label Dose Ranging Study of Oral RH324
NCT05580172
Recruiting
Phase 1 open label dose ranging study of RH324 in advanced non-small cell lung cancer
Gender:
All
Ages:
18 years and above
Trial Updated:
10/11/2022
Locations: Case Comprehensive Cancer Center University Hospitals, Cleveland, Ohio
Conditions: Safety Issues
Register for Updates
Study of TL-895 in Subjects With Myelofibrosis
NCT04655118
Recruiting
This study evaluates TL-895, a potent, orally-available and highly selective irreversible tyrosine kinase inhibitor for the treatment of Myelofibrosis. Participants must be relapsed/refractory (e.g., having failed prior therapy), intolerant, or ineligible to receive JAKi treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/11/2022
Locations: Gabrail Cancer Center, Canton, Ohio
Conditions: Myelofibrosis
Register for Updates
Ketogenic Diet in Patients With Heart Failure
NCT04235699
Recruiting
This study is being done to evaluate the effects of a low carbohydrate ketogenic diet on exercise tolerance in patients with Heart Failure with Preserved Ejection Fraction (HFpEF), also known as Diastolic Heart Failure (DHF).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/10/2022
Locations: The Ohio State University, Columbus, Ohio
Conditions: Heart Failure With Preserved Ejection Fraction
Register for Updates
Critical Health Assessment and Outcomes Score/Study
NCT02766166
Recruiting
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. By integrating approaches from the physical, biological, computational, statistical and clinical sciences, this observational study will test the hypothesis that early diagnosis of subclinical signatures of critical illness encoded within physiologi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/07/2022
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Critical Illness, Death, Sudden
Register for Updates