Ohio is currently home to 3227 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers
NCT06035536
Recruiting
The study will evaluate the safety and performance of Symphony™ versus Standard of Care (SOC) in the treatment of chronic non-healing diabetic foot ulcers (DFU) after 12 weeks of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/11/2025
Locations: Lower Extremity Institute for Research and Therapy, Boardman, Ohio
Conditions: Diabetic Foot, Diabetic Foot Ulcer, Foot Ulcer, Chronic Foot Ulcer
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Personalized Real-Time DBS and PD Mechanisms
NCT06013956
Recruiting
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/11/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Parkinson Disease
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Evaluation of Daily Disposable Toric Soft Lenses Manufactured With an Alternative Hydration Process
NCT06967129
Recruiting
This is a prospective, multi-site, dispensing, randomized, controlled, double-masked, bilateral wear, 2x2 crossover study to evaluate the safety and effectiveness of the test lens.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
05/09/2025
Locations: ProCare Vision Centers, Granville, Ohio
Conditions: Astigmatism
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Efficacy of Cotton as a Dampener for Vibration Anesthetic Device
NCT06916468
Recruiting
The study aims to determine the effectiveness of cotton as a dampener for vibratory anesthetic devices (VADs) for dermatologic patients. It will compare patient preferences for VAD use with and without cotton across different anatomical sites and identify factors, such as chronic pain or neuropathy status, that may influence these preferences. Finally, the study seeks to generate preliminary data to inform potential modifications to VAD use, optimizing patient comfort in dermatologic procedures
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: University Hospitals, Cleveland, Ohio
Conditions: Patient Care
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APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML
NCT06634394
Recruiting
A multi-center, open-label, dose-finding study of five dose levels of APVO436 in combination with venetoclax and azacitidine (ven/aza) in adult patients with newly diagnosed, CD123+ AML.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Gabrail Cancer Center, Canton, Ohio
Conditions: Acute Myeloid Leukemia (AML)
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Restoration of Hand Function in Cervical SCI
NCT06611748
Recruiting
The purpose of this study is to evaluate a new method of restoring hand function to people with spinal cord injury. Current methods to restore hand function include tendon transfers and nerve transfers. This study will evaluate the grasp strength that can be achieved with a small, implantable stimulator. KeyGrip is an investigational device that works by activating paralyzed muscles with low levels of electrical current. The word "investigational" means the study device is still being tested in... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injury Cervical
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Confirmatory Study of PRGN-2012 in Patients With RRP
NCT06538480
Recruiting
The purpose of this confirmatory study is to provide further demonstration of the efficacy of PRGN-2012 for the treatment of RRP in adults.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Recurrent Respiratory Papillomatosis, Papillomavirus Infection, Papillomaviridae
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A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair
NCT06529835
Recruiting
This is a multicenter, prospective, randomized, subject and evaluator blinded clinical trial to asses the efficacy of Auxilium's NeuroSpan Bridge.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/09/2025
Locations: OSU Wexner Medical Center, Columbus, Ohio
Conditions: Peripheral Nerve Injuries
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Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency
NCT06477159
Recruiting
This study aims to evaluate if a 6-month course of pancrelipase (CREON) treatment improves symptoms of exocrine pancreatic insufficiency (EPI) after an attack of acute pancreatitis. Diagnosis of EPI is measured by a fecal elastase value of \<200, and patients must have a qualifying symptom burden based on the EPI symptom tracker survey. Blood and stool will be analyzed as part of this study, and other surveys of health status will be used to track improvement of symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Exocrine Pancreatic Insufficiency
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Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction
NCT06195306
Recruiting
This phase II trial evaluates tamoxifen, with or without omega-3 fatty acids, for reducing risk of breast cancer among postmenopausal and overweight or obese women who are at increased risk of developing breast cancer. Tamoxifen is a selective estrogen receptor modulator. It works by blocking the effects of the hormone estrogen in the breast. Tamoxifen is approved by the Food and Drug Administration for prevention of breast cancer in women at increased risk. Omega-3 fatty acids have been shown t... Read More
Gender:
FEMALE
Ages:
Between 45 years and 65 years
Trial Updated:
05/09/2025
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Breast Atypical Hyperplasia, Breast Carcinoma, Breast Ductal Carcinoma In Situ, Breast Lobular Carcinoma In Situ
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A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
NCT06147037
Recruiting
This is a first-in-human, Phase 1, non-randomized, multicenter, open-label clinical study designed to investigate the safety, tolerability, dosimetry, biodistribution, and pharmacokinetics (PK) of \[225Ac\]-FPI-2068, \[111In\]-FPI-2107, and FPI-2053 in metastatic and/or recurrent solid tumors (HNSCC, NSCLC, mCRC, PDAC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Advanced Solid Tumor, Metastatic Colorectal Carcinoma, Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma
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Protocol CAUSE-03 / CHEETAH
NCT06136091
Recruiting
This is a one-year longitudinal, observational study of 250 urban children and adolescents with asthma and 60 without asthma, ages 6-17 years old. Participants with asthma will require daily controller therapy with inhaled corticosteroids ICS (at least Step 2 therapy). Those without asthma cannot have used asthma medications in the year prior to enrollment and cannot demonstrate bronchodilator reversibility at baseline. Phenotypic characteristics will be established at baseline, and the partici... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
05/09/2025
Locations: Cincinnati Children's Hospital Medical Center: Asthma Center, Cincinnati, Ohio
Conditions: Asthma
Register for Updates