Ohio is currently home to 3199 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Relationship of Exercise, Sleep, and Inflammation Markers in People Living with HIV
NCT04946994
Recruiting
The purpose of this randomized clinical trial is to characterize the effects of two exercise interventions, high-intensity interval training (HIIT) and continuous moderate-intensity exercise (CME), on sleep and inflammation in older people living with HIV (PWH). This study is a sub-study associated with The High Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults with HIV (HEALTH-HIV; NCT04550676). The investigators propose the following aims: Aim 1. Compare the ef... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
10/28/2024
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Hiv, Sleep
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Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
NCT04368039
Recruiting
Single-blind, randomized controlled trial of normobaric oxygen therapy among individuals with first-episode psychosis: Effects on symptomatology and cognition.
Gender:
ALL
Ages:
Between 15 years and 35 years
Trial Updated:
10/28/2024
Locations: Harding Hospital, Columbus, Ohio
Conditions: Psychosis, Schizophrenia, First-episode Psychosis
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The Effects of Dry Needling on Patients with Knee Pain
NCT02890485
Recruiting
This study is testing the effectiveness of "dry needling" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
10/28/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
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Evaluation of an Advanced Lower Extremity Neuroprostheses
NCT00623389
Recruiting
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
10/28/2024
Locations: Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injuries, Stroke, Paralysis, Tetraplegia, Paraplegia
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Essential Fats for Enhancing Cognitive Thinking (EFFECT) Study
NCT06223672
Recruiting
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
10/27/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Cognitive Decline, Cognitive Impairment
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Bioavailability and Pharmacodynamics of EPA and DHA From Fortified Soymilk and Capsules
NCT05802797
Recruiting
This study will compare the algae oil fortified soymilk to a commercial algae oil capsule containing the same base oil with the goal of demonstrating equivalent or greater accumulation of EPA and DHA in blood lipid pools.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/27/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Healthy Diet
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Study to Evaluate the Efficacy and Safety of K-877-ER and CSG452 in Participants With NASH With Liver Fibrosis
NCT05327127
Recruiting
A study to investigate the use of combination therapy with two investigational products for the treatment of adult patients with Nonalcoholic steatohepatitis (NASH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: DSI Research Northridge, Dayton, Ohio
Conditions: NASH
Register for Updates
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
NCT05486572
Recruiting
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mor... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/24/2024
Locations: Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
Conditions: Carcinoma, Hepatocellular, Cirrhosis
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Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
NCT05476497
Recruiting
This phase I clinical trial is designed to evaluate the safety and tolerability of VLP Peanut in healthy subjects and in subjects with peanut allergy (PA). This clinical trial will evaluate the immunotoxicity profile of VLP Peanut in healthy subjects and assess the immunotoxicity profile and the degree of reactogenicity (allergenicity) in subjects with PA. This clinical trial will also explore preliminary proof of efficacy of VLP Peanut in subjects with PA.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
10/24/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Peanut Allergy
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Eccentric Muscle Training, Stimulation, and Biomarkers in SCI
NCT05337982
Recruiting
The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include checking for certain features called biomarkers by testing participants' spinal fluid and blood and compare these features to individuals without SCI. These features will help investigators determine when to start... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/24/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Spinal Cord Injuries, Healthy
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A Phase 1/2 Study of BA3071 in Patients With Solid Tumors
NCT05180799
Recruiting
The objective of this study is to assess safety and efficacy of BA3071 in solid tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: NSCLC, Melanoma
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Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer
NCT04699838
Recruiting
The primary objective of this single arm study is to estimate the progression free survival of previously-untreated patients with extensive stage small cell lung cancer. Patients will receive initial chemo-immunotherapy followed by maintenance therapy with durvalumab and oral ceralasertib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Extensive Stage Small Cell Lung Cancer
Register for Updates