Ohio is currently home to 3212 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Consent for Use of Stored Patient Specimens for Future Testing
NCT00031408
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Univ of Cincinnati, Cincinnati, Ohio
Conditions: HIV Infections
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Comparison of a Demand Oxygen Delivery
NCT06609694
Recruiting
Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea. The aim of the study is to conduct a comparison between the 2 methods of oxygen delivery during sleep in 15 children from Cincinnati Children's Hospital and Children's Hospital of Los Angeles. 2 polysomnographies will be performed, one with continuous flow and the second with pulse flow.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
09/19/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Obstructive Apnea
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Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.
NCT06157177
Recruiting
The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. The main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. All participants will answer questions on Day 1, before treatment, and on 7-day after treatment, about: * Amount and quality of pain * Interference wi... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/19/2024
Locations: Ohio Arthritis and Osteoporosis Center of Southwest Ohio, Springboro, Ohio
Conditions: Sciatica Acute, Lumbar Spinal Stenosis
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Acalabrutinib in Combination with Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia
NCT05336812
Recruiting
This phase II trial tests whether acalabrutinib in combination with venetoclax or obinutuzumab works to shrink tumors in patients with treatment-naive chronic lymphocytic leukemia . Acalabrutinib is also an inhibitor that works in the body to block the activation of certain cells that lead to the growth of cancerous B cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer ce... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/19/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
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Evaluation of Explanted Lungs by MRI and Biological Assays
NCT06012500
Recruiting
The purpose of this multi-centered, NIH-sponsored study is to to develop an optimal protocol for using non-invasive 129Xe gas exchange MRI to detect changing disease activity in interstitial lung diseases (ILDs). We base this study on the demonstrated promise of 129Xe as a biomarker for both prognosis and therapy response, overwhelming interest from both industry and academic partners, and impending FDA approval for 129Xe ventilation MRI. This requires disseminating standardized and repeatable m... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
09/18/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: ILD
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Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials
NCT04580368
Recruiting
The purpose of this study is to validate and utilize a personalized medicine approach to identify potential treatments with current FDA approved CFTR modifiers for non-approved CF gene mutations. The study will perform ex vivo testing of CFTR function and current marketed CFTR modulating drugs on expanded nasal cells at Cincinnati Children's Human Nasal Epithelium (HNE) Core Laboratory. The results will be confirmed and translated into bedside care through an N of 1 trial to determine effectiven... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
09/18/2024
Locations: CCHMC, Cincinnati, Ohio
Conditions: Cystic Fibrosis
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Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
NCT03785249
Recruiting
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: The Christ Hospital, Cincinnati, Ohio
Conditions: Advanced Cancer, Metastatic Cancer, Malignant Neoplastic Disease
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Hp129 Xenon Imaging and BOS in Lung Transplantation
NCT03603899
Recruiting
The research is being conducted to develop new imaging methods that are sufficiently sensitive to allow for early diagnosis of BOS, a chronic allograft rejection affecting 50-60% of lung transplanted recipients who survive 5 years after transplant. Although lung transplantation has evolved into an effective therapeutic option for a large number of pediatric patients with end-stage pulmonary disease, long-term survival after lung transplantation is far worse than after the transplantation of othe... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
09/18/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Bronchiolitis Obliterans
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Neuroblastoma Maintenance Therapy Trial
NCT02679144
Recruiting
Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg/m2 ± 250 mg/m2 BID (strata 1, 2, 3, and 4) OR 2500 mg/m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
09/18/2024
Locations: Cleveland Clinic Children's, Cleveland, Ohio
Conditions: Neuroblastoma
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Relationships Between Exercise and Appetite in Women with Loss of Control Eating
NCT06602973
Recruiting
This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
09/17/2024
Locations: Ohio University, Athens, Ohio
Conditions: Eating Disorders, Binge-Eating Disorder, Bulimia Nervosa
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Positive Processes and Transition to Health (PATH)
NCT06093906
Recruiting
The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stressor-related symptoms of PTSD and/or depression, and are elevated on symptoms related to 2 of the 3 therapeutic targets. Additionally, this study will examine Positive Processes and Transition to Healt... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/17/2024
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Posttraumatic Stress Disorder, Major Depressive Disorder
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CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease)
NCT04748861
Recruiting
The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing or delaying disease onset will transform AD treatment, improve patient outcomes and quality of life, and reduce health care costs.
Gender:
ALL
Ages:
Between 65 years and 80 years
Trial Updated:
09/17/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: High Intensity Exercise, Normal Cognition, Exercise Intervention
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