Ohio is currently home to 3225 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of BLB-201 RSV Vaccine in Infants and Children
NCT05655182
Recruiting
This Phase 1/2a trial is a randomized, placebo-controlled trial to evaluate the safety, tolerability and immunogenicity of two ascending doses (10\^6 PFU and 10\^7 PFU) of intranasal BLB-201 (a recombinant parainfluenza virus type 5) administered in infants (8-24 months of age) and children (18-59 months of age) who may or may not have had prior respiratory syncytial virus (RSV) infection.
Gender:
ALL
Ages:
Between 6 months and 5 years
Trial Updated:
08/26/2024
Locations: Velocity Clinical Research, Cleveland, Beachwood, Ohio
Conditions: Respiratory Syncytial Virus Infections
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Treatment for Migraine and Mood
NCT05576467
Recruiting
The researchers propose a three-arm pilot study of Mindfulness-Based Cognitive Therapy (MBCT) delivered via telephone (MBCT-T), video (MBCT-V) or Enhanced Usual Care (EUC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: The Cleveland Clinic, Cleveland, Ohio
Conditions: Migraine, Depressive Symptoms
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The Impact of Abdominal Wall Reconstruction on Abdominal Wall Tension and Intra-Abdominal Pressure
NCT06575166
Recruiting
This is a prospective cohort study. Patients have an incisional or parastomal hernia with \>20 cm fascial defect on pre-operative imaging who will undergo an anticipated open bilateral transversus abdominis release with retromuscular synthetic mesh will have their abdominal wall tension measured using a tension scale and their intra-abdominal pressure measured using a urinary catheter containing pressure sensors. The investigators aim to quantify the changes, as well as explore and describe the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/25/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Ventral Hernia, Incisional Hernia, Parastomal Hernia
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Risk of Nerve Damage After Administration of Local Anesthesia
NCT06564987
Recruiting
This research aims to evaluate of the risk of nerve damage following the administration of articaine 4% and lidocaine 2% for Inferior Alveolar nerve Block (IANB). A Randomized Controlled Clinical Trial will be conducted where the patient will be randomly assigned to one the two groups; articaine 4% and Lidocaine 2%. The type of LA will be concealed to the operator, investigators and assessors. The patients will be monitored for any aigns of nerve parathesia for 3 months after the procedure.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/23/2024
Locations: Cleveland Dental Institute, Akron, Ohio
Conditions: Inferior Alveolar Nerve Injuries
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Grasp-Release Assessment of a Networked Neuroprosthesis Device
NCT05863754
Recruiting
The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/23/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injury at C5-C7 Level, Spinal Cord Injuries, Spinal Cord Injury Cervical
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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
NCT05855200
Recruiting
The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: GSK Investigational Site, Akron, Ohio
Conditions: Colonic Neoplasms, Neoplasms, Colon
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: Children's Hospital Medical Center of Akron, Akron, Ohio
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms
NCT05526352
Recruiting
The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA). The SwissNeuroFoundation AneurysmDataBase are concerned with generating the data with which to populate this database. The purpose for populating the database are to: * Screen for and evaluate markers of risk for intracranial aneurysm formation and aneurysm rupture. Are considered as mar... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: University of Cincinnati College of Medicine, Cincinnati, Ohio
Conditions: Intracranial Aneurysm
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An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis
NCT05505981
Recruiting
Spondylolysis, a stress fracture in the pars interarticularis of a lumbar vertebra, is the most common identifiable cause of low back pain (LBP) in adolescent athletes, occurring in 14-30% of athletes who experience LBP. Spondylolysis can cause significant pain and disability and months of exclusion from sports or an active lifestyle. Standard care of spondylolysis in adolescent athletes is primarily based on expert opinion, with dramatic variations in clinical practice, including restrictive br... Read More
Gender:
ALL
Ages:
Between 10 years and 19 years
Trial Updated:
08/23/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Lumbar Spondylosis
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The GUARDIAN Trial
NCT04884802
Recruiting
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/23/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Blood Pressure
Register for Updates
Fenofibrate for Prevention of DR Worsening
NCT04661358
Recruiting
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME at baseline. In addition to evaluating efficacy, this study aims to evaluate the feasibility of a model for ophthalmologists to prescribe or collaborate with a primary care provider such as an internist/endocrinologist to prescribe and monitor the dru... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/23/2024
Locations: The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio
Conditions: Diabetic Retinopathy
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Influenza IMPRINT Cohort: Defining the Impact of Initial Influenza Exposure on Immunity in Infants
NCT05436184
Recruiting
The primary aim is to define the immune responses to the infant's initial influenza exposure (vaccine or infection) and how that affects the immune response to subsequent influenza exposures
Gender:
ALL
Ages:
All
Trial Updated:
08/21/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Influenza
Register for Updates