Ohio is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Connected Through Coaching for Flourishing Families
NCT06145451
Recruiting
Despite the known association between the quality of participant relational engagement with service providers and clinical outcomes, limited studies have examined caregiver Relational Responsiveness (RR) as a mechanism to achieve maltreatment prevention program outcomes. Using a realist-informed mixed method approach, this study will examine RR's role in mediating the effects of a community-based maltreatment prevention program, the Family Success Network (FSN) on protective factors against malt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Maltreatment by Parent
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FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer
NCT06636682
Recruiting
The goal of this clinical trial is to learn if the vaccine FK-PC101 works to delay or prevent the return of prostate cancer in men who have had surgery to remove their prostate cancer. It will also learn about the safety of FK-PC101. The main questions it aims to answer are: Does FK-PC101 delay or prevent the return of prostate cancer following surgery? What medical problems do participants (subjects) have when taking FK-PC101? Researchers will compare FK-PC101 to current treatment practice to... Read More
Gender:
MALE
Ages:
All
Trial Updated:
10/17/2024
Locations: Central Ohio Urology Group, Gahanna, Ohio
Conditions: Prostate Cancer (Adenocarcinoma), Prostate CA, Prostate Cancers, Prostate Cancer (Post Prostatectomy), Prostate Cancer, Prostate Cancer Patients Undergoing Radical Prostatectomy, High-risk Prostate Cancer
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LMY-920 for Treatment of Relapsed or Refractory Myeloma
NCT05546723
Recruiting
Since CAR-T cell treatment of refractory myeloma has shown success, based on preclinical data, we posit that CAR-T cells expressing B-cell activating factor (BAFF) can become another strategy to treat refractory myeloma, even after relapse following BCMA targeting CAR-T cell treatment. This will be phase 1 study of BAFF ligand CAR-T cells in relapsed and refractory myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: University Hospitals Seidman Cancer Center, Cleveland, Ohio
Conditions: Multiple Myeloma, Refractory, Multiple Myeloma in Relapse
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Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Non-Hodgkin Lymphoma
NCT05312801
Recruiting
Therapy with chimeric antigen receptor T (CAR-T) cells has demonstrated activity against refractory lymphoma, however not all tumors respond or remain in response to CD19 targeted CAR-T cells. We posit that CAR-T cells expressing BAFF (BAFF CAR-T cells) can become another strategy to treat refractory lymphoma, even after relapse following cluster of differentiation antigen 19 (CD19) targeting CAR-T treatment. This phase 1 study will evaluate safe dose and provide initial signal of the activity... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: University Hospitals Seidman Cancer Center, Cleveland, Ohio
Conditions: Lymphoma, Non-Hodgkin Lymphoma, B-Cell
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A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
NCT04475926
Recruiting
This study will follow participants who are screened and confirmed with a genetic diagnosis of Limb-girdle muscular dystrophy type 2E (LGMD2E/R4), Limb-girdle muscular dystrophy type 2D (LGMD2D/R3), Limb-girdle muscular dystrophy type 2C (LGMD2C/R5), or Limb-girdle muscular dystrophy type 2A (LGMD2A/R1). These enrolled participants will be followed to evaluate mobility and pulmonary function for up to 5 years after enrollment for participants with LGMD2C/R5, LGMD2D/R3, and LGMD2E/R4 with a Nort... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
10/16/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Limb-girdle Muscular Dystrophy
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A Post-Market Clinical Evaluation of the Treatment of Femur Fractures With the Femoral Nail GT
NCT04015128
Recruiting
This investigation is a prospective, multi-center clinical investigation. It is anticipated that a total of 50 subjects will be enrolled. Neither subjects nor investigators are blinded to treatment and the clinical investigation includes a historical control which will be compared to the Femoral Nail GT of the T2 Alpha Femur Antegrade GT/PF Nailing System. Total duration of enrollment, 12 month follow-up and analysis is expected to take 25 months. The clinical investigation has been designed to... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/16/2024
Locations: UC Health, Cincinnati, Ohio
Conditions: Femoral Fracture
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Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers
NCT06644664
Recruiting
This clinical trial evaluates the effect of message framing on smoking behaviors among lesbian, gay, bisexual, transgender, queer (LGBTQ+) young adults who use nicotine and/or tobacco. Tobacco regulation has contributed to a steady decline in tobacco products designed to be smoked (combustible), but there has been an increase in the use of new tobacco products, such as electronic nicotine delivery systems (ENDS). The use of more than one tobacco product (polytobacco) is high in LGBTQ+ population... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
10/15/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Tobacco-Related Carcinoma
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The PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep Apnea
NCT05428839
Recruiting
This study is an exploratory, multicenter study of up to 300 subjects diagnosed with obstructive sleep apnea who are being evaluated for airway surgery. Subjects will undergo standard evaluation for airway surgery as part of standard of care. In addition to the standard airway assessment, a simple, non-invasive measurement of the width of the inside of each subjects mouth will be performed. This measurement takes 2-3 minutes to perform.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: Ohio State University, Columbus, Ohio
Conditions: Sleep Apnea, Obstructive
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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
NCT02977780
Recruiting
This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib * Temozolomide (temodar) * Neratinib * CC115 * QBS10072S
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Glioblastoma
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Rebuilding Inter-limb Transfer in Cervical SCI
NCT06440538
Recruiting
The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic motor and hand dexterity skills.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/11/2024
Locations: Lerner Research Institute; Cleveland Clinid Foundation, Cleveland, Ohio
Conditions: Cervical Spinal Cord Injury
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Janus Feasibility Study
NCT03985527
Recruiting
The purpose of this feasibility study is to assess whether an alternative transvenous lead location affects respiration and airway physiology during a commercial remedē® System or commercial transvenous cardiac device (de novo pacemaker or implantable cardiac defibrillator) implant procedure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Sleep Apnea Syndromes
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Corneal Elastography and Patient Specific Modeling
NCT03030755
Recruiting
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have compu... Read More
Gender:
ALL
Ages:
Between 16 years and 80 years
Trial Updated:
10/11/2024
Locations: Cleveland Clinic Foundation Cole Eye Institute, Cleveland, Ohio
Conditions: Cornea; Ectasia, Refractive Errors, Keratoconus
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