Ohio is currently home to 3226 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Risk of Nerve Damage After Administration of Local Anesthesia
NCT06564987
Recruiting
This research aims to evaluate of the risk of nerve damage following the administration of articaine 4% and lidocaine 2% for Inferior Alveolar nerve Block (IANB). A Randomized Controlled Clinical Trial will be conducted where the patient will be randomly assigned to one the two groups; articaine 4% and Lidocaine 2%. The type of LA will be concealed to the operator, investigators and assessors. The patients will be monitored for any aigns of nerve parathesia for 3 months after the procedure.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/23/2024
Locations: Cleveland Dental Institute, Akron, Ohio
Conditions: Inferior Alveolar Nerve Injuries
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Grasp-Release Assessment of a Networked Neuroprosthesis Device
NCT05863754
Recruiting
The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/23/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injury at C5-C7 Level, Spinal Cord Injuries, Spinal Cord Injury Cervical
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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
NCT05855200
Recruiting
The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: GSK Investigational Site, Akron, Ohio
Conditions: Colonic Neoplasms, Neoplasms, Colon
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: Children's Hospital Medical Center of Akron, Akron, Ohio
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis
NCT05505981
Recruiting
Spondylolysis, a stress fracture in the pars interarticularis of a lumbar vertebra, is the most common identifiable cause of low back pain (LBP) in adolescent athletes, occurring in 14-30% of athletes who experience LBP. Spondylolysis can cause significant pain and disability and months of exclusion from sports or an active lifestyle. Standard care of spondylolysis in adolescent athletes is primarily based on expert opinion, with dramatic variations in clinical practice, including restrictive br... Read More
Gender:
ALL
Ages:
Between 10 years and 19 years
Trial Updated:
08/23/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Lumbar Spondylosis
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The GUARDIAN Trial
NCT04884802
Recruiting
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/23/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Blood Pressure
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Influenza IMPRINT Cohort: Defining the Impact of Initial Influenza Exposure on Immunity in Infants
NCT05436184
Recruiting
The primary aim is to define the immune responses to the infant's initial influenza exposure (vaccine or infection) and how that affects the immune response to subsequent influenza exposures
Gender:
ALL
Ages:
All
Trial Updated:
08/21/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Influenza
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Study to Evaluate the PK of IV and PO Omadacycline in Children and Adolescents With Suspected or Confirmed Bacterial Infections
NCT05217537
Recruiting
The purpose of this study is to evaluate the pharmacokinetics of a single dose of intravenous or oral omadacycline in children and adolescents with suspected or confirmed bacterial infections.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
08/21/2024
Locations: Site 106, Cleveland, Ohio
Conditions: Bacterial Infections
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Conditions: Multiple Myeloma
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Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors
NCT06416007
Recruiting
The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Cancer, Metastatic Cancer, Locally Advanced, Locally Advanced Solid Tumor, Locally Advanced Carcinoma
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NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow
NCT06373978
Recruiting
This study is a double-blind, randomized controlled trial comparing the effectiveness of oral acetaminophen, diclofenac, and tramadol in reducing the consumption of narcotic doses (primary outcome) and minimizing patients' exposure to narcotics (secondary outcome) following an ultrasound-guided percutaneous needle tenotomy procedure on the lateral elbow.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/20/2024
Locations: The Cleveland Clinic Ohio, Avon, Ohio
Conditions: Elbow Pain, Chronic Pain
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Promoting Healing of Injured Nerves With Electrical Stimulation Therapy
NCT05884125
Recruiting
This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for peripheral nerve injury in arm. Participants will be randomized into one of two groups, treatment or control, with all participants receiving standard of care treatment for the nerve injury. The treatment group will also receive a single dose of the therapeutic stimulation during the surgical intervention for their nerve injury.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/20/2024
Locations: The Ohio State Univeristy - Department of Plastic and Reconstructive Surgery, Columbus, Ohio
Conditions: Nerve Injury, Peripheral Nerve Injuries, Peripheral Nerve Injury Upper Limb, Nerve Palsy
Register for Updates