Ohio is currently home to 3200 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Safety Study of PP-007 in Subjects With Acute Ischemic Stroke
NCT04677777
Recruiting
The HEMERA-1 Extension (Part III) is a prospective, open-label, multicenter study to evaluate safety of two doses of PP-007 in Acute Ischemic Stroke (AIS) subjects receiving Intravenous Thrombolysis (IVT) or mechanical thrombectomy (MT) or IVT+MT as standard of care (SOC). Subjects will receive two doses of PP-007 infusion 24 ± 6 hours apart in addition to the site-specific SOC protocol. PP-007 is PEGylated bovine carboxyhemoglobin and will be administered via IV infusion. The effects on collate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Mercy Health - St. Vincent Medical Center, Toledo, Ohio
Conditions: Acute Ischemic Stroke
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Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)
NCT04623099
Recruiting
This double-blind, 12-week study will consist include132 anxious youth who are randomized (1:1) to standard or pharmacogenetically-guided escitalopram dosing. Block randomization (1:1) will be stratified by sex and metabolizer status.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxiety
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Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
NCT04245748
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxious Depression, Depression
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Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
NCT04245436
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by open-label naturalistic follow-up.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Anxiety, Depressive Symptoms
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Improving Stroke Motor Control With Non-invasive Brain Stimulation and Functional Electrical Stimulation
NCT03857529
Recruiting
This pilot study for stroke patients with chronic upper limb hemiplegia will examine the effects of non-invasive brain stimulation and neuromuscular electrical stimulation on hand motor control and corticospinal excitability. Specifically, this study will investigate the effects of timing and delivery of tDCS in conjunction with contralaterally controlled functional electrical stimulation.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
08/28/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Stroke, Rehabilitation, Hand
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Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
NCT00921986
Recruiting
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Arrhythmias, Cardiac
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REFRaME-O1: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin Versus Investigator's Choice (IC) Chemotherapy in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1
NCT05870748
Recruiting
A Phase 2/3 study to investigate the efficacy and safety of luveltamab tazevibulin versus IC chemotherapy in women with ovarian cancer (including fallopian tube or primary peritoneal cancers) expressing FOLR1.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Platinum-resistant Ovarian Cancer
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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
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A Study to Assess the Effect of Venetoclax on Ethinyl Estradiol and Levonorgestrel in Female Participants With Different Hematological Malignancies
NCT03557619
Recruiting
A study to assess the effect of multiple doses of venetoclax on the pharmacokinetics of ethinyl estradiol and levonorgestrel in female participants with different hematological malignancies. Upon completion of this study, participants receiving clinical benefit in the opinion of the investigator and without any clinically significant evidence of disease progression with no access to venetoclax (not approved for the treated indication) may continue receiving venetoclax at the discretion of the in... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Gabrail Cancer Center Research /ID# 207039, Canton, Ohio
Conditions: Hematologic Malignancies
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The APS Phenotyping Study
NCT06521502
Recruiting
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: ARDS, Sepsis, Pneumonia
Register for Updates
Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders
NCT06227780
Recruiting
Fragile X Syndrome (FXS) is a complex neurodevelopmental disorder caused by a mutation on the X chromosome. Scientists have investigated FXS extensively in both humans and animals. Thus far, phenotypic rescue in animal models has not resulted in treatment breakthroughs in humans, though some important discoveries have been made. Research has shown that individuals with FXS process sounds differently than those in the typical population, and they also show baseline differences in brain activity,... Read More
Gender:
ALL
Ages:
Between 5 years and 10 years
Trial Updated:
08/26/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Fragile X Syndrome, Autism Spectrum Disorder, Autistic Disorder, Asperger Syndrome
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tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia
NCT05866003
Recruiting
After a stroke, it is very common to lose the ability to open the affected hand. Occupational and physical rehabilitation therapy (OT and PT) combined with non-invasive brain stimulation may help a person recover hand movement. The purpose of this study is to compare 3 non-invasive brain stimulation protocols combined with therapy to see if they result in different amounts of recovery of hand movement after a stroke.
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
08/26/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Stroke, Upper Extremity Paresis, Hemiplegia
Register for Updates