Ohio is currently home to 3229 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831
Recruiting
This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy. The study will be conducted in 2 parts. Part 1 will evaluate safety and efficacy of two different doses of navtemadlin alongside an observational control arm to determine the Phase 3 navtemadlin dose. Part 2 will evaluate the efficacy and safety of navtemadlin Phase 3 dose compared to placebo.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: OhioHealth Institute, Columbus, Ohio
Conditions: Endometrial Cancer
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Connect® Myeloid Disease Registry
NCT01688011
Recruiting
The purpose of the Connect® Myeloid disease registry is to provide unique insights into treatment decisions and treatment patterns as they relate to clinical outcomes of patients with myeloid diseases in routine clinical practice. This disease registry will also evaluate molecular and cellular markers that may provide further prognostic classification which may or may not be predictive of therapy and clinical outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Summa Health System, Akron, Ohio
Conditions: Myelodysplastic Syndromes, Primary Myelofibrosis, Leukemia, Myeloid, Acute
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Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
NCT05412810
Recruiting
The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics. The investigators will include patients with mechanical ventilation and have received FiO2=\>0.5 atleast 90 minutes and collected two sequential mini bronchoalveolar lavage on them 24 hours apart. Mass Spectrometry Lipid chromatography will be conducted and clinical data will be analyzed.
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
04/25/2024
Locations: Ohio State University Medical Center, Columbus, Ohio
Conditions: Mechanical Ventilation Complication, Hyperoxia
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A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning
NCT06387485
Recruiting
This prospective, multi-center, randomized controlled study aims to assess the efficacy of utilizing 3D printed models in preoperative planning for the excision of tumors involving bony structures within the body. The study is expected to last approximately 12 months and involve up to 150 subjects across 3 sites. Subjects will be randomized in a 1:1 ratio into either the experimental arm, utilizing 3D printed models and imaging, or the active comparator arm, using only imaging. Primary endpoint... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
04/23/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Sarcoma, Ewing, Chondrosarcoma, Osteosarcoma, Fibrous Histiocytoma, Fibrosarcoma
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The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
NCT05688904
Recruiting
The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Wright State Physicians, Fairborn, Ohio
Conditions: Imipramine, Photodynamic Therapy, Actinic Keratosis
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Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.
NCT04771572
Recruiting
This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up to 100 subjects.
Gender:
ALL
Ages:
13 years and above
Trial Updated:
04/23/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Non Hodgkin Lymphoma, Richter Transformation, Multiple Myeloma, T-cell-prolymphocytic Leukemia, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Myeodysplastic Syndrome, Myelofibrosis, Myelodysplastic/Myeloproliferative Neoplasm, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Chronic Myelomonocytic Leukemia-2, Myelodysplastic Neoplasm in Blast Phase
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Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration
NCT02316379
Recruiting
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Respiratory Disorders
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Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults
NCT02272049
Recruiting
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.
Gender:
ALL
Ages:
6 years and above
Trial Updated:
04/23/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Respiratory Disorders
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Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation
NCT06056271
Recruiting
Observational, multi-center, clinical device registry for US patients with a primary goal to observe the clinical outcomes in patients who are mapped with Volta Medical's VX1 or AF-Explorer systems during AF ablation procedures.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/22/2024
Locations: Ohio State University, Columbus, Ohio
Conditions: Atrial Fibrillation
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Intravenous Oliceridine and Opioid-related Complications
NCT04979247
Recruiting
The investigator will evaluate the side effects of oliceridine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2024
Locations: Cleveland Clinic Fairview Hospital, Cleveland, Ohio
Conditions: Major Surgery
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Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea
NCT04712656
Recruiting
The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.
Gender:
ALL
Ages:
Between 30 years and 75 years
Trial Updated:
04/19/2024
Locations: Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio
Conditions: Sleep Apnea, Obstructive
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Ancora-SB Overtube Complete Positioning and Optical Visualization During Endoscopic Procedures
NCT06111131
Recruiting
Demonstrate superiority of the Aspero Medical Ancora-SB balloon Overtube compared to the Olympus ST-SB1 Balloon Overtube.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/18/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Small Bowel Disease
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