Ohio is currently home to 3199 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
DOD Regulating Together Intervention
NCT05803369
Recruiting
Our long-term goal is to validate Regulating Together (emotion regulation intervention) and improve psychosocial outcomes for youth with autism spectrum disorder and emotion dysregulation.
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
04/04/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Autism Spectrum Disorder, Emotion Regulation
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Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer
NCT05168163
Recruiting
This phase II trial tests whether atezolizumab in combination with a multi-kinase inhibitor (cabozantinib or lenvatinib) compared to multi-kinase inhibitor alone in treating patients with liver cancer that cannot be removed by surgery (unresectable), has spread to has spread to nearby tissue or lymph nodes (locally advanced), or has spread to other places in the body (metastatic), for which the patient has received treatment in the past (previously treated). Immunotherapy with monoclonal antibod... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Locally Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IVA Hepatocellular Carcinoma AJCC v8, Stage IVB Hepatocellular Carcinoma AJCC v8, Unresectable Hepatocellular Carcinoma
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ARGONAUT: Stool and Blood Sample Bank for Cancer Patients
NCT04638751
Recruiting
ARGONAUT is a longitudinal, prospective, observational study that will enroll up to 5,000 advanced-stage cancer patients of diverse racial backgrounds to collect data used to develop precision microbiome medicines and for the identification of clinically actionable cancer-specific biomarkers to guide therapeutic decisions. Four types of solid tumor cancers will be profiled including non-small cell lung cancer (NSCLC), triple negative breast cancer (TNBC), colorectal cancer (CRC) and pancreatic c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2024
Locations: Kroger Health, The Little Clinic, Cincinnati, Ohio
Conditions: Non-small Cell Lung Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Pancreas Cancer
Register for Updates
Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy
NCT06070233
Recruiting
A scientific study is being done to test a special treatment for people who have spasticity or tight muscles. This treatment is called "stereotactic radiosurgery dorsal rhizotomy." It uses very accurate beams of radiation to target certain nerves in the back to help loosen up the muscles. In this study, people are put into two groups by chance: one group gets the real treatment, and the other group gets a "fake" treatment that doesn't do anything. This fake treatment is called a "sham." Doing th... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
04/02/2024
Locations: Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Spasticity as Sequela of Stroke, Spastic Cerebral Palsy, Spasticity, Muscle
Register for Updates
Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis
NCT05521022
Recruiting
This is a multicenter, international, three-part, Phase 1 study designed to evaluate the safety, tolerability, and PK of rising single doses of AT-02 in healthy volunteers and in subjects with systemic amyloidosis and to assess the safety, tolerability, and PK of multiple doses of AT-02 in subjects with systemic amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Amyloidosis; Systemic
Register for Updates
Regional Monitoring of CF Lung Disease
NCT06339593
Recruiting
The main reason for this research study is to learn more about some new tests that are being developing for patients with Cystic Fibrosis (CF) to measure changes in the lungs. In this study, the focus will be to learn how stopping Airway Clearance (ACT) and re-starting ACT can affect these tests. These new tests include using a breathable gas called Xenon (Xe) with MRI (magnetic resonance imaging) to improve the pictures of changes in the lungs. The Xenon (Xe) gas that has been treated to have a... Read More
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
03/29/2024
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Cystic Fibrosis
Register for Updates
Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support
NCT05668637
Recruiting
Invasive mechanical ventilation is one of the most important and life-saving therapies in the intensive care unit (ICU). In most severe cases, extracorporeal lung support is initiated when mechanical ventilation is insufficient. However, mechanical ventilation is recognised as potentially harmful, because inappropriate mechanical ventilation settings in ICU patients are associated with organ damage, contributing to disease burden. Studies revealed that mechanical ventilation is often not provide... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2024
Locations: Cleveland Clinic Foundation, Cleveland, USA, Cleveland, Ohio
Conditions: Invasive Mechanical Ventilation
Register for Updates
Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening
NCT04968548
Recruiting
This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
03/28/2024
Locations: Summa Health, Akron, Ohio
Conditions: Lung Cancer
Register for Updates
CERAMENT™| Bone Void Filler Device Registry
NCT04244942
Recruiting
A device registry to compile data on the performance of CERAMENT BONE VOID FILLER in normal use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Orthopedic Disorder
Register for Updates
Exparel and Education to Avoid Opioids After Carpal Tunnel Release
NCT03867539
Recruiting
This trial seeks to use the long acting local anesthetic Exparel, in conjunction with opioid education, to attempt to avoid any post-operative opioid use following carpal tunnel surgery. This group will be compared with a "standard" group that receives non-liposomal bupivacaine, opioid education, and opioids.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Orthopedic Associates of Southwest Ohio, Dayton, Ohio
Conditions: Carpal Tunnel Syndrome
Register for Updates
Single Blinded First CMC Osteoarthritis Treatment
NCT03196310
Recruiting
Single blinded PRP vs. Corticosteroid vs. Placebo (normal saline) intra-articular injection for basal joint arthritis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Orthopedic Associates of Southwest Ohio, Centerville, Ohio
Conditions: Osteoarthritis Thumb
Register for Updates
Pilot Study Evaluating the Elasticity and Shear Wave Modulus (Stiffness) of the Median Nerve in Patients With Mild to Moderate Idiopathic Carpal Tunnel Syndrome Receiving OMT and Conservative Therapy
NCT06150443
Recruiting
To evaluate and quantify changes in the elasticity and shear wave modulus (stiffness) of the median nerve in patients diagnosed with mild to moderate carpal tunnel syndrome following osteopathic manipulative therapy.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/25/2024
Locations: Kettering Health, Dayton, Ohio
Conditions: Carpal Tunnel Syndrome
Register for Updates