Ohio is currently home to 3313 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial
NCT04316013
Recruiting
VAPOR-C is a randomised study of the impact of IV versus inhaled anaesthesia (propofol versus sevoflurane) and lidocaine versus no lidocaine on duration of disease free survival inpatients with either colorectal or non small cell lung cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/21/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Colonic Cancer, Rectal Cancer, Non Small Cell Lung Cancer
Register for Updates
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
NCT02205762
Recruiting
The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years).
Gender:
All
Ages:
18 years and below
Trial Updated:
03/21/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Langerhans Cell Histiocytosis
Register for Updates
Promoting Healing Of Nerves Through Electrical Stimulation
NCT04662320
Recruiting
This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for nerve compression. A single dose of the therapeutic stimulation is delivered as part of the surgical intervention to address compression of the ulnar nerve at the elbow.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/20/2023
Locations: The Ohio State Univeristy - Department of Plastic and Reconstructive Surgery, Columbus, Ohio
Conditions: Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
Register for Updates
DNA-Guided Second Line Adjuvant Therapy For High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer
NCT04567420
Recruiting
A randomized, Phase II trial of circulating tumor DNA-guided second line Adjuvant therapy for high Residual risk, stage II-III, Estrogen Receptor positive, HER-2 negative breast cancer (DARE)
Gender:
All
Ages:
All
Trial Updated:
03/20/2023
Locations: The Ohio State University Wexner Medical Center James Cancer Hospital, Columbus, Ohio
Conditions: Breast Cancer
Register for Updates
Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
NCT01187368
Recruiting
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2023
Locations: The Christ Hospital, Cincinnati, Ohio
Conditions: Heart Failure
Register for Updates
Blood Test (Guardant Shield™) for Screening of Colorectal Cancer in Underserved Patients
NCT05716477
Recruiting
This clinical trial evaluates the use of a blood test (Guardant Shield™) for colorectal cancer screening. Colorectal cancer is the third leading cancer and cause of death in the United States. Screening may help doctors find colorectal cancer early when it is easier to treat yet nearly a third of all people eligible for screening have never had a screening test performed. Currently, doctors use a stool- based test such as the fecal immunochemical test (FIT) and visual tests such as a colonoscopy... Read More
Gender:
Female
Ages:
45 years and above
Trial Updated:
03/16/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Colorectal Carcinoma
Register for Updates
A Study of Dexlansoprazole Delayed-Release Capsules to Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children
NCT02616302
Recruiting
The main aims of the study are to see the side effects of Dexlansoprazole treatment effectiveness of Dexlansoprazole treatment in children having symptomatic nonerosive gastroesophageal reflux disease (GERD). Participants will take Dexlansoprazole by mouth once daily for 12 weeks
Gender:
All
Ages:
Between 2 years and 11 years
Trial Updated:
03/15/2023
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Gastroesophageal Reflux Disease (GERD)
Register for Updates
NT-3 Levels and Function in Individuals With CMT
NCT05011006
Recruiting
This study will assess the serum NT-3 levels in individuals with the diagnosis of peripheral neuropathy or any type of Charcot-Marie-Tooth Neuropathy (CMT) and correlate this with function.
Gender:
All
Ages:
7 years and above
Trial Updated:
03/13/2023
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Charcot-Marie-Tooth Disease, Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyneuropathy
Register for Updates
A Study Of The Selective PKC-β Inhibitor MS- 553
NCT03492125
Recruiting
A Phase I/II Dose-Escalation and Expansion Study Of The Selective PKC-Β Inhibitor MS-553 In Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Gender:
All
Ages:
18 years and above
Trial Updated:
03/13/2023
Locations: The Ohio State University, James Comprehensive Cancer Center, Columbus, Ohio
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Aggressive Lymphoma
Register for Updates
A Study of ICP-192 in Patients With Advanced Solid Tumors
NCT04565275
Recruiting
This is a multi-center, open-label, phase I/II clinical study to evaluate ICP-192 in patients with advanced solid tumors and FGFR gene alterations. It consists of two parts: Part I (Phase I), dose escalation and Part II (Phase II), dose expansion.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/12/2023
Locations: The Ohio State University, Columbus, Ohio
Conditions: Advanced Solid Tumors, Urothelial Carcinoma, Cholangiocarcinoma
Register for Updates
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease
NCT05012631
Recruiting
This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older for 12 months. The investigators will enroll 24 patients with SCD over the course of 1 year with a goal to complete all study procedures in 2 years. The short-term goal is to obtain clinical pilot data regarding the safety and efficacy of losartan in stabilizing or decreasing extracellular volume fraction (ECV) after 12 months of therapy.
Gender:
All
Ages:
6 years and above
Trial Updated:
03/09/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Sickle Cell Disease, Diffuse Myocardial Fibrosis
Register for Updates
Artificial Intelligence Mobile Health Trial Of A Digital Platform To Optimize GDMT Using Wearable Sensors
NCT04191330
Recruiting
The goal of this real-world, multi-center, randomized, outpatient study is to assess the effectiveness of the Biofourmis cloud based BiovitalsHFTM platform to recommend optimal titration of Guideline-Directed Medical Therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) subjects.
Gender:
All
Ages:
22 years and above
Trial Updated:
03/09/2023
Locations: Premier Cardiovascular Institute, Dayton, Ohio
Conditions: Heart Failure
Register for Updates