Ohio is currently home to 3183 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Measurement of the Optic Nerve Sheath Diameter
NCT05548335
Recruiting
This study is a prospective assessment of the accuracy of ocular ultrasound as a tool to measure the diameter of the optic nerve sheath and the eyeball transverse diameter in healthy adult patients presenting to the Emergency Department and have confirmatory imaging of the optic nerve as part of their clinical care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Cleveland Clinic Akron General, Akron, Ohio
Conditions: Optic Nerve
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The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
NCT03631225
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Paramount Medical Research & Consulting, LLC, Middleburg Heights, Ohio
Conditions: Rheumatoid Arthritis (RA)
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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
NCT05919342
Recruiting
This is an international prospective, multicentre, unblinded, randomised-controlled trial. The primary aim is to assess a targeted screening strategy to detect undiagnosed heart failure in high-risk patients.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/02/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Cardiovascular Diseases
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Groningen International Study on Sentinel Nodes in Vulvar Cancer-III
NCT05076942
Recruiting
Vulvar cancer patients with SN-metastasis \> 2mm will receive chemoradiation instead of an inguinofemoral lymphadenectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Vulvar Cancer, Sentinel Lymph Node, Lymph Node Metastases
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Total Shoulder Arthroplasty Multi-Center Registry
NCT03511586
Recruiting
The objective of the study is a multi-center prospective registry to collect clinical outcomes of anatomic and reverse total shoulder arthroplasty.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/27/2023
Locations: Cleveland Shoulder Institute, Beachwood, Ohio
Conditions: Shoulder Arthroplasty
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Therapeutic Response Evaluation and Adherence Trial (TREAT)
NCT02286154
Recruiting
The primary objectives of this prospective study of hydroxyurea for children with sickle cell anemia are 1) Develop and prospectively evaluate a population pharmacokinetic/pharmacodynamics model to predict the maximum tolerated dose (MTD); 2) Identify urine biomarkers of hydroxyurea adherence using a novel metabolomics approach; 3) Identify pharmacogenomics modifiers of hydroxyurea MTD; and 4) Longitudinal monitoring of the effect of hydroxyurea upon organ function and quality of life.
Gender:
ALL
Ages:
Between 6 months and 21 years
Trial Updated:
07/27/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Anemia, Sickle Cell
Register for Updates
A Safety and Pharmacokinetics Study of IDP-118 Lotion in Pediatric Participants With Plaque Psoriasis
NCT03988439
Recruiting
This study is to evaluate the safety, the systemic exposure, and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-118 lotion in pediatric participants with moderate to severe plaque psoriasis.
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
07/25/2023
Locations: Bausch Site 11, Mayfield Heights, Ohio
Conditions: Psoriasis
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Design Validation Hemodynamic Study of New Kendall SCD SmartFlow Compression System
NCT05945186
Recruiting
This study is being conducted to evaluate the hemodynamic performance (i.e. flow of blood) in the legs using the new Kendall SCD SmartFlow™ compression system with Cardinal Health Element compression sleeves.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/13/2023
Locations: Jobst Vascular Institute, Toledo, Ohio
Conditions: Hemodynamics
Register for Updates
CPAP Adherence Pilot Study Among African Americans
NCT05955287
Recruiting
The goal of the study is to determine the feasibility of a behavioral intervention to improve CPAP adherence among African American patients with obstructive sleep apnea.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/12/2023
Locations: MetroHealth Medical System, Cleveland, Ohio
Conditions: Sleep Apnea
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An All Comers Registry For Normothermic Ex Vivo Lung Perfusion (EVLP) as Assessment of Donor Lungs for Transplant
NCT05101460
Recruiting
The XVIVO Registry is to collect standard of care clinical data from "all-comers" who are transplanted with an EVLP lung treated with the XVIVO Perfusion System™ in order to assess the long-term performance of the device, and monitor device-related serious adverse events. In addition, 4 and 5-year UNOS registry data of the 126 subjects who received an EVLP transplant under the NOVEL and NOVEL Extension studies are provided as part of the long-term safety and quality of life data. In addition, 4... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2023
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Lung Transplant
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Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study
NCT05950711
Recruiting
The purpose of this study is to assess the feasibility of combining IV ketamine, a rapid acting antidepressant, with a course of Mindfulness-Based Cognitive Therapy (MBCT), for the initial and maintenance treatment of depression.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/10/2023
Locations: Harding Hospital, Columbus, Ohio
Conditions: Major Depressive Disorder
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Magnetocardiography as a Noninvasive Diagnostic Strategy for Identifying Coronary Allograft Vasculopathy
NCT05751915
Recruiting
Purpose: To show early feasibility of magnetocardiography (MCG) to identify coronary Cardiac positron emission tomography (PET) is the preferred non-invasive tests to assess for CAV and incorporation of quantitative myocardial blood flow (MBF) assessment improves diagnostic accuracy. Based on ISHLT criteria, the following have been proposed for diagnosis of CAV by PET:
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: The Cleveland Clinic, Cleveland, Ohio
Conditions: Coronary Allograft Vasculopathy (CAV)
Register for Updates