Ohio is currently home to 3314 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Psychologically Informed Education Intervention for Adolescents With Atraumatic Lower-Extremity Injuries
NCT05701618
Recruiting
This is a randomized prospective study assessing the impact of psychosocial factors on pain and physical performance among adolescents with leg pain. A set of psychosocial surveys assessing activity-related fear, stress, anxiety and depression will be completed by the participants. Participants will then complete self-report questionnaires assessing pain, quality of life and functional ability followed by an assessment of physical activity levels assessed with a wearable activity monitor;. Parti... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
01/30/2023
Locations: Nationwide Children's Hospital Sports and Ortho Physical Therapy, Columbus, Ohio
Conditions: Leg Injury
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A Performance Evaluation Study of Arquer's MCM5 Elisa Test (ADXBLADDER) to Aid in the Monitoring of Recurrence in Non-Muscle Invasive Bladder Cancer
NCT05508568
Recruiting
The objective of this prospective, multi-centre study is to evaluate the performance of ADXBLADDER, a urine MCM5 ELISA test, as an aid in the detection of bladder cancer recurrence. Patients undergoing cystoscopic surveillance in non-muscle invasive bladder cancer (NMIBC) follow-up will be recruited and asked to provide a urine sample to be tested with ADXBLADDER. To assess the diagnostic accuracy of the test, the MCM5 results will be compared with the gold standard cystoscopy and pathology of r... Read More
Gender:
All
Ages:
22 years and above
Trial Updated:
01/30/2023
Locations: Clinical Research Solutions, Cleveland, Ohio
Conditions: Bladder Cancer
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A Study of Navicixizumab Monotherapy or in Combination in Patients With Select Advanced Solid Tumors
NCT05453825
Recruiting
This is a study of navicixizumab monotherapy or in combination with paclitaxel or irinotecan in patients with advanced cancer. Patients will be enrolled into one of the following cancer cohorts: Cohort A: CRC Cohort B: Gastric and GEJ cancer Cohort C: TNBC Cohort D: Platinum-resistant/refractory epithelial ovarian, primary peritoneal, or fallopian tube cancer (ovarian cancer)
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: The Zangmeister Cancer Center, Columbus, Ohio
Conditions: Colorectal Cancer, Triple Negative Breast Cancer, Gastric Cancer, Ovarian Cancer
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Improving Outcomes Using Technology for Children Who Are DHH
NCT02998164
Recruiting
This study evaluates the efficacy of using augmentative and alternative communication (AAC) technology for enhancing language development in children who are deaf or hard of hearing. Half of the participants will receive AAC technology with their speech and language therapy and half will continue with their usual care models.
Gender:
All
Ages:
Between 3 years and 10 years
Trial Updated:
01/26/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Hearing Loss, Language Development, Social Behavior
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CorMatrix Cor TRICUSPID ECM Valve Replacement Study
NCT02397668
Recruiting
The Pivotal Study of the Cor TRICUSPID ECM Valve (or Cor PEDIATRIC Tricuspid ECM Valve). This study follows the EFS and is now to determine the safety and efficacy of the Cormatrix Cor TRICUSPID Valve for any patients requiring surgical replacement of the tricuspid valve.
Gender:
All
Ages:
Between 1 year and 70 years
Trial Updated:
01/25/2023
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Tricuspid Valve Disease
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Safety and Tolerability of FB-001 in Healthy Adult Volunteers and Adult Subjects With Enteric Hyperoxaluria
NCT05650112
Recruiting
This Phase 1, first-in-human, randomized, double-blinded, placebo controlled study is evaluating FB-001 in healthy volunteers (Part 1) and participants diagnosed with enteric hyperoxaluria (Part 2). Eligible participants receive investigational product and undergo safety monitoring, evaluations and subsequent follow-up after investigational product administration.
Gender:
All
Ages:
Between 18 years and 74 years
Trial Updated:
01/23/2023
Locations: Medpace Clinical Pharmacology Unit, Cincinnati, Ohio
Conditions: Healthy, Enteric Hyperoxaluria
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Corneal Elastography and Patient Specific Modeling
NCT03030755
Recruiting
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have compu... Read More
Gender:
All
Ages:
Between 16 years and 80 years
Trial Updated:
01/23/2023
Locations: Cleveland Clinic Foundation Cole Eye Institute, Cleveland, Ohio
Conditions: Cornea; Ectasia, Refractive Errors, Keratoconus
Register for Updates
Peripheral Nerve Stimulation(PNS) for Subacromial Impingement Syndrome(SIS)
NCT03752619
Recruiting
Shoulder pain accounts for 16% of all musculoskeletal complaints in the healthy adult population. Subacromial impingement syndrome (SIS) is the most common cause of shoulder pain. Many patients with chronic pain from subacromial impingement syndrome (SIS) will fail treatment efforts and have longstanding pain. This project will evaluate the efficacy of a novel approach to treatment, percutaneous peripheral nerve stimulation, for participants with chronic shoulder pain due to subacromial impingem... Read More
Gender:
All
Ages:
Between 21 years and 100 years
Trial Updated:
01/20/2023
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Shoulder Pain, Shoulder Impingement Syndrome, Shoulder Tendinitis, Shoulder Bursitis, Pain, Shoulder
Register for Updates
Buccal Film vs IV Palonosetron for Prevention of CINV in Cancer Patients Receiving MEC
NCT05199818
Recruiting
The phase 3 study is to compare the efficacy and safety of palonosetron, a long-acting 5-HT3 receptor antagonist, by buccal film delivery compared to IV injection for the prevention of chemotherapy-induced nausea and vomiting. Subjects receive a single dose of palonosetron prior to moderately emetogenic chemotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/19/2023
Locations: Tri-County Hematology & Oncology Associates, Massillon, Ohio
Conditions: Chemotherapy-induced Nausea and Vomiting
Register for Updates
Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting
NCT05702762
Recruiting
The purpose of this research study is to determine if gentamicin is as effective treatment of acute uncomplicated cystitis (urinary tract infection) using aminoglycosides versus the current standards of care. The current standards of care in our region are often to prescribe a multi-day antibiotic prescription that is taken multiple times per day whereas gentamicin will be a one-time dose in the emergency department. Gentamicin is the medicine being studied.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/18/2023
Locations: St. Elizabeth Youngstown Hospital, Youngstown, Ohio
Conditions: Urinary Tract Infections
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Clinical Validation of the Ameda Pearl - An Electric, Hospital Grade, Multi-User Breast Pump
NCT05297799
Recruiting
This study introduces a new Ameda electric multi-user, hospital-grade breast pump, the Ameda Pearl, to mothers who choose to exclusively breast pump until their infants are able to breastfeed.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/18/2023
Locations: Summa Health, Akron, Ohio
Conditions: Breast Pumping
Register for Updates
Move to Improve: Telehealth Exercise to Music for HD
NCT05270681
Recruiting
The purpose of this study is to determine if a movement to music exercise program delivered via telehealth is feasible and safe for individuals with neurodegenerative disease and their caregivers (Aim 1). A secondary aim will be to determine if a movement to music exercise program delivered via telehealth improves balance, cognition, mobility, and quality of life (Aim 2).
Gender:
All
Ages:
21 years and above
Trial Updated:
01/18/2023
Locations: The Ohio State University, Columbus, Ohio
Conditions: Huntington Disease
Register for Updates