Ohio is currently home to 3201 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
NCT00736749
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
Gender:
ALL
Ages:
All
Trial Updated:
07/22/2025
Locations: Children's Hospital Medical Center of Akron, Akron, Ohio
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
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DEVELOPMENT OF A NOVEL PEER RECOVERY SUPPORTER TRAINING PLATFORM
NCT07044531
Recruiting
The focus of this study is to assess the effect on Peer Recovery Support Service providers of the fully asynchronous training platform (TDPP) and the TDPP with live zoom sessions on skill and adherence compared with training-as-usual.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Thrive Digital Health, Solon, Ohio
Conditions: Substance Use Disorders, Alcohol Use Disorders, Recovery Support Services, Peer Recovery Coaching
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Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
NCT06898515
Recruiting
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve System to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure (ADHF). The main objective is to determine if the Reprieve System can more efficiently decongest ADHF patients in comparison to Control Therapy.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
07/21/2025
Locations: Lindner Center at Christ Hospital, Cincinnati, Ohio
Conditions: Acute Decompensated Heart Failure
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Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC
NCT06864819
Recruiting
This study aims to see if there's a link between a substance called phosphatidylethanol (PEth) and how patients who have surgery at University Hospitals do after surgery. PEth levels reflect the amount of alcohol use by someone over the past few weeks. This study is checking PEth levels on all patients who are planned to stay in the hospital for three or more days after surgery regardless if they drink alcohol. Specifically, it will look at if PEth levels are connected to problems that might com... Read More
Gender:
ALL
Ages:
Between 21 years and 79 years
Trial Updated:
07/21/2025
Locations: University Hospital, Cleveland, Ohio
Conditions: Postoperative Complications, Alcohol Use Disorder
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Study of BMN 349 Single Dose in PiZZ and PiMZ/MASH Adult Participants
NCT06738017
Recruiting
The goal of this clinical trial is to assess the safety and tolerability of a single oral dose of BMN 349 in participants with PiZZ or PiMZ/MASH. Primary outcome measures include incidence of any adverse events (including serious adverse events, dose limit toxicities, and adverse events of special interest), incidence of any laboratory test abnormalities, incidence of lung function test abnormalities and 12-lead ECG parameters. Participants will receive a single dose of either BMN 349 or place... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/21/2025
Locations: Medpace Clinical Pharmacology Unit, Cincinnati, Ohio
Conditions: Alpha 1-Antitrypsin Deficiency
Register for Updates
Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors
NCT06635785
Recruiting
BIPAVE-001 is a Phase 1-2 study for evaluating the safety, pharmacokinetics (PK), and efficacy of AI-081 in solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: The Ohio State University James Cancer Center, Columbus, Ohio
Conditions: Advanced Solid Tumor
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A Study of ZW191 in Participants With Solid Tumors
NCT06555744
Recruiting
The purpose of this study is to find out if ZW191 is safe and can treat participants with advanced cancers, including ovarian, endometrial, and non-small cell lung cancers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio
Conditions: Advanced Solid Tumors
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INHANCE Stemless Reverse Shoulder IDE
NCT06323980
Recruiting
2:1 Randomized, Controlled, Multi-Center, Prospective, Pre-Market Study of the INHANCE Stemless Reverse Cementless Total Shoulder.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
07/21/2025
Locations: Crystal Clinic Orthopaedic Center, Akron, Ohio
Conditions: Arthroplasty, Replacement, Shoulder
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Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)
NCT06319287
Recruiting
A Phase 2a Multi-Center, Prospective, Randomized, Controlled Study to Evaluate the Safety and Efficacy of Topically Applied PEP-TISSEEL in Subjects with Diabetic Foot Ulcers (DFU)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Professional Education & Research Institute (PERI), Blue Ash, Ohio
Conditions: Diabetic Foot Ulcer
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A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
NCT06223360
Recruiting
The purpose of this study is to learn more about the safety, effectiveness and tolerability of the study drug called Benfotiamine which may delay or slow the progression of the symptoms of early Alzheimer's disease.
Gender:
ALL
Ages:
Between 50 years and 89 years
Trial Updated:
07/21/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Alzheimer Disease
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A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)
NCT06211764
Recruiting
The purpose of this study is to compare disease free survival (DFS) in participants with recurrence of papillary-only high-risk non-muscle-invasive bladder cancer (HR-NMIBC) within 1 year of last dose of Bacillus Calmette-Guérin (BCG) therapy and who refused or are unfit for Radical Cystectomy (RC), receiving TAR-200 versus investigator's choice of single agent intravesical chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: The Urology Group, Cincinnati, Ohio
Conditions: Non-Muscle Invasive Bladder Neoplasms
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Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines
NCT05972759
Recruiting
Twenty-five participants with PD utilizing the Medtronic Percept PC DBS system will be enrolled for this project and complete a single bout of both FE and VE. The 150-minute experimental session will be completed in the OFF antiparkinsonian and Off-DBS state.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Parkinson Disease
Register for Updates