Tennessee is currently home to 1929 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Nashville, Memphis, Knoxville and Chattanooga. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
NCT01885299
Recruiting
The RSSearch® Registry is an international multi-year database designed to track SRS/SBRT (Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy) utilization, treatment practices and outcomes to help determine, over time, the most effective use of these systems in management of patients with life threatening tumors and other diseases. (This study was formally called ReCKord and included the CyberKnife only; The ReCKord study continues as a CyberKnife subset of RSSearch.)
Gender:
ALL
Ages:
All
Trial Updated:
09/17/2024
Locations: Cyberknife at Erlanger, Chattanooga, Tennessee
Conditions: Neoplasms, Arteriovenous Malformation of Central Nervous System, Trigeminal Neuralgia
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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VYN201 Gel in Subjects with Non-segmental Vitiligo.
NCT06493578
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of VYN201 Gel in subjects with non-segmental vitiligo.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
09/16/2024
Locations: Cumberland Skin Center for Clinical Research, Hermitage, Tennessee
Conditions: Non-segmental Vitiligo
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Next Generation Rocklatan
NCT06441643
Recruiting
The purpose of this two-stage clinical trial is to assess the safety and hypotensive efficacy of AR-17043 and PG043 ophthalmic solutions in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: University Eye Specialists, Maryville, Tennessee
Conditions: Open Angle Glaucoma, Ocular Hypertension
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Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
NCT05501236
Recruiting
Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from variable response at the level of the soft palate. The Investigators propose a study examining the physiologic effect of ansa cervicalis stimulation (ACS) alone and in combination with HNS during PSG a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Obstructive Sleep Apnea
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Cooperative Assessment of Late Effects for SCD Curative Therapies
NCT05153967
Recruiting
Sickle Cell Disease is one of the most common genetic diseases in the United States, occurring in approximately 1 in 400 births. Approximately 100,000 individuals are diagnosed with SCD in the United States. Mortality for children with SCD has decreased substantially over the past 4 decades, with \>99% of those born in high resource settings, including the United States, France, and England, now surviving to 18 years of age. However, the life expectancy of adults with SCD is severely shortened.... Read More
Gender:
ALL
Ages:
Between 4 years and 65 years
Trial Updated:
09/16/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Sickle Cell Disease, Pulmonary Disease, Renal Disease, Heart Disease
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Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies
NCT04521413
Recruiting
The purpose of this study is to test the safety of an investigational drug called CFI-402411 alone and in combination with pembrolizumab and to study its effects in patients with advanced solid tumors who have progressed following previous therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: SCRI - Nashville, Nashville, Tennessee
Conditions: Advanced Solid Malignancies
Register for Updates
Activity Monitoring in Pulmonary Hypertension
NCT04101630
Recruiting
This is a prospective, longitudinal, observational study of free-living activity trackers and patient reported outcomes to test the hypothesis that daily activity will have stronger prognostic value than 6MWD in patients with pulmonary hypertension after 12 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Pulmonary Hypertension
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Study of SGR-2921 in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
NCT05961839
Recruiting
The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) and/or recommended dose (RD) of SGR-2921.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/13/2024
Locations: TriStar Bone Marrow Transplant, LLC, Nashville, Tennessee
Conditions: Acute Myeloid Leukemia, High-Risk and Very High-Risk Myelodysplastic Syndromes
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Hormonal, Metabolic, and Signaling Interactions in PAH
NCT01884051
Recruiting
Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.
Gender:
ALL
Ages:
90 years and below
Trial Updated:
09/13/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Scleroderma Associated Pulmonary Arterial Hypertension, Appetite Suppressant Associate PAH
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Wearable Technology to Evaluate Hyperglycemia and HRV in DMD - Longitudinal Aim
NCT06093100
Recruiting
Duchenne Muscular Dystrophy (DMD) is an X-linked disorder that causes muscle wasting, cardiopulmonary failure, and premature death. Heart failure is a leading cause of death in DMD, but substantial knowledge gaps exist regarding predisposing risk factors. In the general population, hyperglycemia, insulin resistance, and decreased heart rate variability (HRV; reflecting autonomic dysfunction) are associated with cardiomyopathy (CM). It is unclear whether these factors are associated with DMD-CM.... Read More
Gender:
MALE
Ages:
10 years and above
Trial Updated:
09/12/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Duchenne Muscular Dystrophy
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Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device
NCT04839705
Recruiting
A prospective, multicenter, single arm, interventional study. The target patient population for this study are adult subjects with WNBAs of the anterior and posterior intracranial circulation. The primary effectiveness outcome of the study is adequate intracranial aneurysm occlusion on the 1 year angiogram as adjudicated by a core laboratory.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Semmes Murphey, Memphis, Tennessee
Conditions: Wide Neck Bifurcation Intracranial Aneurysms
Register for Updates
Selinexor and Backbone Treatments of Multiple Myeloma Patients
NCT02343042
Recruiting
This study will independently assess the efficacy and safety of 11 combination therapies in 12 arms, in dose-escalation/-evaluation and expansion phases, for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) and newly diagnosed multiple myeloma (NDMM). The combinations to be evaluated are: * Arm 1: Selinexor + dexamethasone + pomalidomide (SPd); enrollment complete * Arm 2: Selinexor + dexamethasone + bortezomib (SVd); enrollment complete * Arm 3: Selinexor + dexamethas... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2024
Locations: Sarah Cannon- Tennessee Oncology Nashville, Nashville, Tennessee
Conditions: Multiple Myeloma
Register for Updates