Tennessee is currently home to 1926 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Nashville, Memphis, Knoxville and Chattanooga. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Interventions for Reading Disabilities in NF1
NCT02964884
Recruiting
Neurofibromatosis Type 1 (NF1) is a common genetic disorder that is associated with a four times greater risk of learning disabilities, including reading disabilities, and a deficiency of neurofibromin - a protein important in a signaling pathway that regulates learning and memory. Our previous work (NS49096) demonstrated that school-age children with NF+RD can respond to standard phonologically-based reading tutoring originally developed to treat reading disability in the general population. Co... Read More
Gender:
ALL
Ages:
Between 8 years and 20 years
Trial Updated:
06/08/2024
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Neurofibromatosis Type 1, Learning Disability, Reading Disability, NF1
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Clinical Utility of Residual Hearing in the Cochlear Implant Ear
NCT04707885
Recruiting
The current study is a randomized multi-center clinical trial that investigates the role an intraoperative hearing monitoring system (electrocochleography) has on helping to save residual hearing in patients undergoing cochlear implantation (CI).
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
06/05/2024
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Hearing Loss, Sensorineural, Hearing Loss, Hearing Loss, Bilateral
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Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
NCT02682511
Recruiting
The purpose of this phase 2 multicenter, randomized, double-blind, placebo-controlled, study is to assess the safety and efficacy of ifetroban in patients with diffuse cutaneous systemic SSc (dcSSc) or SSc-associated pulmonary arterial hypertension (SSc-PAH).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/05/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Scleroderma, Diffuse, Scleroderma, Systemic, Scleroderma, Limited, Sclerosis, Progressive Systemic, Skin Diseases, Connective Tissue Diseases, Pathologic Processes, Autoimmune Diseases
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Comprehensive Postpartum Management for Women With Hypertensive Disorders of Pregnancy
NCT05849103
Recruiting
Investigators propose a comprehensive management program for postpartum patients with HDP who are at risk for severe maternal morbidity and mortality. Our program will emphasize three key components: 1) self-monitoring of blood pressures with app-based reporting connected to our electronic health record, 2) blood pressure management directed by a program navigator with guideline and physician support and 3) facilitated transitions of care to primary care clinicians for hypertension management. I... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Hypertension, Pregnancy-Induced, Postpartum Preeclampsia, Hypertension; Maternal
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Validation of Cutaneous Nerve Demyelination in Diagnosis and Treatment of CIDP
NCT05614128
Recruiting
The goal of this observational study is to learn about chronic inflammatory demyelinating polyneuropathy. The main question the investigators would like to answer is 1) can skin biopsy identify demyelination better than nerve conduction studies (electrical tests of the nerves)? and 2) how do nerves improve after treatment in CIDP? Participants will be asked to undergo skin biopsy of the finger at baseline and at 3 months and 6 months after treatment with IVIG (which is the FDA approved treatment... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/04/2024
Locations: Peltier Amanda, Nashville, Tennessee
Conditions: CIDP
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Study on Basal Joint Arthritis Prospective
NCT01376024
Recruiting
The data in this prospective registry will be used 1) to define which surgical and nonoperative techniques are most effective at providing pain relief, restoring function, are cost effective, and patients are satisfied with their outcomes; and 2) to design focused clinical questions regarding the optimal treatment of basal joint arthritis of the thumb in future randomized controlled trials. There are no interventions or changes in patient care associated with this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: Vanderbilt University Hospital, Nashville, Tennessee
Conditions: Osteoarthrosis of the Carpometacarpal Joint of the Thumb
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OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier
NCT06447844
Recruiting
The study will be a multi-site, randomized, two-arm, controlled clinical trial using OsteoGen® Plug (Test) vs Freeze-dried Bone Allograft with collagen barrier (Control) for alveolar ridge preservation (ARP) in posterior extraction sites with intact buccal cortical plates.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/03/2024
Locations: Perio & Implant Associates of Middle TN, Nashville, Tennessee
Conditions: Nonterminal Premolar Needing Extraction
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A Pilot Study to Evidence Improved Cranial Flap Fixation With a Bioresorbable Bone Adhesive
NCT06095531
Recruiting
This clinical pilot study will evaluate the use of a bioresorbable bone adhesive to improve cranial flap fixation at two study time points (at the time of fixation and 6 months). The aim of this Pilot Study is to demonstrate the safety and efficacy of the use of Tetranite for Cranial Flap Fixation (TN-CFF) to allow clinical study of the TN-CFF device in a greater number of patients.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/03/2024
Locations: Semmes Murphey Clinic, Memphis, Tennessee
Conditions: Craniotomy
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Eliminating Monitor Overuse Trial (EMO Trial)
NCT05132322
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee
Conditions: Bronchiolitis Acute Viral
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Respiratory Strength Training in Heart Transplant Recipients
NCT06190171
Recruiting
This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery. Previous studies have shown that breathing exercises can improve breathing, cough, and swallow function in patients with other diseases/conditions. The current study will investigate the impact of a preoperative respiratory muscle strength training program on breathing and cough function, swallow function, patient-reported eating and swallowing fatigue... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/31/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Dysphagia, Heart Transplant Recipients
Register for Updates
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
NCT05313165
Recruiting
A prospective, single-arm, multi-center study designed to gather additional information on the LimFlow System.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
05/31/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Register for Updates
A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction
NCT03776162
Recruiting
This study is designed to evaluate bridge-enhanced ACL restoration (BEAR), a new surgical technique for repairing knees injured by a tear of the anterior cruciate ligament (ACL) that promotes reattachment and healing of the ACL using a blood-enriched implant. BEAR will be compared to bone to patellar tendon to bone autograft (BPTB) reconstruction, a standard ACL surgical reconstruction technique that replaces a torn portion of the ACL with transplanted patellar tendon tissue, and thus requires a... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/31/2024
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Anterior Cruciate Ligament Tear
Register for Updates