Tennessee is currently home to 1928 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Nashville, Memphis, Knoxville and Chattanooga. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Understanding the Cognition and Decision Making of Community Anesthesiologists
Recruiting
The investigators are interested in studying why experienced clinicians make specific decisions regarding the monitoring of patients' physiological states and why clinicians might make decisions that are contrary to current best practices or known evidence. More generally, the program objective is to refine and validate a novel methodology to delineate clinicians' decision-making strategies. More specifically, the investigators will study the decision to reverse neuromuscular blockade at the end... Read More
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
02/03/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Neuromuscular Blockade
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Sarah Cannon Research Institute, Nashville, Tennessee
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
VALOR: Vaginal Atrophy & Long-term Observation of Recovery
Recruiting
Vulvovaginal skin conditions, namely vaginal atrophy, lichen sclerosus, lichen simplex chronicus and lichen planus affecting the female adult population will be treated with a novel gel dressing to test the short- and long-term safety and efficacy of the device.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: WR-Medical Research Center of Memphis, LLC, Memphis, Tennessee
Conditions: Atrophic Vaginitis, Vaginal Atrophy, Genitourinary Syndrome of Menopause, Lichen Sclerosus of Vulva, Lichen Planus of Vulva, Lichen Simplex of Vulva (Disorder)
The Acute Burn ResUscitation Multicenter Prospective Trial
Recruiting
This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: The University of Tennessee Health Science Center, Memphis, Tennessee
Conditions: Burn Injury
A Study to Evaluate Safety, Tolerability and Preliminary Activity of LB101 in Participants With Advanced Solid Tumors
Recruiting
The purpose of this study is to assess safety, tolerability, and preliminary activity of LB101 monotherapy in participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2024
Locations: Sarah Cannon Research Institute at Tennessee Oncology Nashville, Nashville, Tennessee
Conditions: Advanced Solid Tumor
Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
Recruiting
The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Kidney Stones, Nephrolithiasis
A Randomized Multicenter Study for Isolated Skin Vasculitis
Recruiting
Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2024
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Primary Cutaneous Vasculitis, Cutaneous Polyarteritis Nodosa, IgA Vasculitis, Henoch-Schönlein Purpura
Metabolic Effects of Angiotensin-(1-7)
Recruiting
The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity. Pharmacologic approaches to increase angiotensin-(1-7) levels or its actions are currently in development for treatment of metabolic-related diseases such as obesity and type II diabetes, based on findings from animal studies. It is unclear if this peptide contributes to the regulation of metabolism in humans. The investigators will test if a... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/30/2024
Locations: Vanderbilt University School of Medicine, Nashville, Tennessee
Conditions: Obesity, Insulin Resistance, Hypertension, Metabolic Cardiovascular Syndrome
Physiologic Pacing for Symptomatic First-Degree Heart Block
Recruiting
The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Ascension Saint Thomas Midtown, Nashville, Tennessee
Conditions: Symptomatic First-degree Heart Block
Subscapularis Repair in Reverse Shoulder Arthroplasty
Recruiting
This study will evaluate the subscapularis repair versus non-repair during a reverse shoulder arthroplasty (RSA).
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
01/29/2024
Locations: The Campbell Clinic, Collierville, Tennessee
Conditions: Rotator Cuff Tear Arthropathy
Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
Recruiting
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Soft Tissue Sarcomas
Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)
Recruiting
This is a multi-center, double-masked, randomized, placebo-controlled, parallel-group, efficacy, safety, and tolerability study evaluating the efficacy of Dupilumab in the treatment of signs and symptoms of atopic keratoconjunctivitis (AKC).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Blink Research Center, Memphis, Tennessee
Conditions: Atopic Keratoconjunctivitis