Tennessee is currently home to 1927 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Nashville, Memphis, Knoxville and Chattanooga. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Augmenting Benzodiazepine Receptor Agonist Deprescribing With Acupuncture and Yoga Among Older Adults
NCT06197243
Recruiting
The main purpose of this 12-week study is to see if a new combination of treatments can help older adults reduce benzodiazepine or related medication use. The treatment combination consists of 1) medical provider visits to gradually reduce the medication dose over 12 weeks, 2) acupuncture treatments, and 3) private yoga classes. Participants will be offered weekly visits for 12 weeks to receive combined treatments. Participants will be provided surveys before, during, and after the study to lear... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/19/2024
Locations: Osher Center for Integrative Health at Vanderbilt, Nashville, Tennessee
Conditions: Anxiety, Insomnia, Benzodiazepine, Deprescription
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Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
NCT04028492
Recruiting
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/19/2024
Locations: Vanda Investigational Site, Chattanooga, Tennessee
Conditions: Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
Register for Updates
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Nashville, Tennessee
Conditions: Neoplasms
Register for Updates
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
NCT05820919
Recruiting
This study seeks to improve clinical outcomes for an important, growing, and vulnerable population-nursing home residents with Alzheimer's disease or related dementias-by testing an evidence-based intervention to improve these residents' sleep. It will also examine the implementation and sustainment of this intervention.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/11/2024
Locations: National HealthCare Corporation, Murfreesboro, Tennessee
Conditions: Alzheimer Disease, Dementia, Sleep Disorder, Sleep Disturbance
Register for Updates
Long-Term Clinical, Immunologic, and Virologic Profiles of Children Who Received Early Treatment for HIV
NCT05154513
Recruiting
IMPAACT 2028 is an observational prospective study to characterize a cohort of early treated children who may participate in future research related to HIV remission or cure. Up to approximately 250 participants will be in the study for approximately seven years. No intervention is provided in the study.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: St. Jude Childrens Research Hosp, Memphis (6501), Memphis, Tennessee
Conditions: HIV Infection
Register for Updates
A Phase 1 Study of NM6603 in Advanced Solid Tumors
NCT06046066
Recruiting
This study is to assess the MTD and RP2D of NM6603 in adult patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Tennessee Oncology, PLLC, Nashville, Tennessee
Conditions: Cancers
Register for Updates
Parallel Versus Perpendicular Technique for Lumbar Medial Branch Radiofrequency Neurotomy
NCT03912519
Recruiting
Low back pain is a leading cause of disability worldwide. The lumbar zygapophyseal joints (z-joints) are estimated to be the source of low back pain between 10% and 40% of the time. Observational studies have shown that lumbar medial branch radiofrequency neurotomy (LMBRFN) can be an effective treatment for z-joint low back pain. Nonetheless, other publications such as the Cochrane collaboration systematic review and the "Minimal Interventional Treatments for Participants with Chronic Low Back P... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
03/07/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Back Pain Without Radiation, Low Back Pain, Lumbar Radiofrequency Neurotomy
Register for Updates
Ruxolitinib + Allogeneic Stem Cell Transplantation in AML
NCT03286530
Recruiting
This research study is studying a drug that may help decrease the chances of relapse after Allogeneic Stem Cell transplantation for Acute Myeloid Leukemia. The name of the study drug involved in this study is: • Ruxolitinib
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
03/06/2024
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission, Allogeneic Stem Cell Transplantation
Register for Updates
Evaluation of Radiobiological Effects in Skin Toxicities for Breast Cancer Patients With Pencil Beam Scanning Proton Therapy
NCT06006806
Recruiting
This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for breast patients treated with PBS. They will also use a special computer model to study how the energy of the proton beam (linear energy transfer) is related to these skin reactions. The study involves creating a treatment plan based on a CT sca... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Thompson Proton Center, Knoxville, Tennessee
Conditions: Breast Cancer, Breast Cancer Stage II, Breast Cancer Stage III, Breast Cancer Stage I
Register for Updates
Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery
NCT04885244
Recruiting
Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients treated with minimally invasive approach, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Semmes-Murphey, Memphis, Tennessee
Conditions: Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance
Register for Updates
Stool Sample Collection Study
NCT06294873
Recruiting
The primary objective of this study is to obtain de-identified stool specimens from participants with colonoscopic biopsy-based histopathologic diagnosis of colorectal cancer (CRC) and/or a ≥1 cm colorectal polyp/adenoma/mass found during pre-enrollment colonoscopy that is of sufficient size to require surgical excision or complex colonoscopic polypectomy. The samples will be used for the purpose of research and development of a new molecular diagnostic test for the detection of neoplasms of th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2024
Locations: Gastro One, Cordova, Tennessee
Conditions: Colorectal Cancer
Register for Updates
A Study of AND019 in Women With ER Positive HER2 Negative Advanced or Metastatic Breast Cancer
NCT05187832
Recruiting
This is a first in human dose escalation and expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD) activity, and preliminary anti-tumor activity of AND019 in postmenopausal women with advanced or metastatic estrogen receptor (ER)-positive (human epidermal growth factor receptor 2 \[HER2\]-negative) breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/28/2024
Locations: Sarah Cannon Research Institute, Nashville, Tennessee
Conditions: Advanced or Metastatic Breast Cancer
Register for Updates