Minnesota is currently home to 2074 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
NCT05875948
Recruiting
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hepatorenal Syndrome, Acute Kidney Injury
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Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Minneapolis Heart Institute / Abbott Northwestern Hospital, Minneapolis, Minnesota
Conditions: Abdominal Aortic Aneurysm
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Longitudinal Study to Determine the Effectiveness of the Mobility Checkup for Older Adults
NCT05745402
Recruiting
The investigators are developing a new, preventative physical therapy model of care for older adults called Mobility Checkup (MC). Proposed as an annual visit, the MC includes measurement of physical performance and education regarding the importance of maintaining mobility for overall health. The purpose of this study is to determine the feasibility of and begin data collection for, a longitudinal study of the effectiveness of the Mobility Checkup with a small cohort. This activity will evaluat... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
09/25/2023
Locations: College of St. Scholastica-Health Science Center, Duluth, Minnesota
Conditions: Healthy Aging
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PV Loop and Pulmonary Hypertension
NCT05484596
Recruiting
The right ventricular (RV) systolic function is a key determinant of outcome in patients with pulmonary hypertension and elevated pulmonary vascular resistance. As the pulmonary artery pressure and vascular resistance increase (i.e. RV afterload) in these patients, so does the right ventricular contractility in an attempt to maintain cardiac output. This is response of a ventricle to its afterload is termed ventriculo-arterial (VA) coupling. However, there is a limit to this increase in contract... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
09/22/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pulmonary Vascular Resistance Abnormality
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OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
NCT03747458
Recruiting
This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo). For the PK sub-study, up to 14 subjec... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
09/22/2023
Locations: Children's Minnesota, Minneapolis, Minnesota
Conditions: Bilateral Nasal Polyposis
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Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury
NCT04933448
Recruiting
The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI). The secondary objective is a preliminary evaluation of the outcomes of children who have had the standard of care plus the KD, compared to those with standard of care alone. Outcome measures for the secondary objective will include: need for ventriculoperitoneal shunt, duration of unconsciousness, need for any ty... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
09/15/2023
Locations: Gillette Children's Specialty Healthcare, Minneapolis, Minnesota
Conditions: Traumatic Brain Injury
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A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
NCT04786574
Recruiting
The primary objective of this study is to evaluate the effect of tolvaptan on the need for renal replacement therapy in pediatric subjects with autosomal recessive polycystic kidney disease (ARPKD)
Gender:
ALL
Ages:
Between 28 days and 12 weeks
Trial Updated:
09/14/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Autosomal Recessive Polycystic Kidney Disease (ARPKD)
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Safety Study of OA-235i in Subjects With Nonalcoholic Steatohepatitis
NCT05680233
Recruiting
This study is a Phase 1, first-in-human single-dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of OA-235i in subjects with nonalcoholic steatohepatitis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/05/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver
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Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries With Multiple Myeloma
NCT03127761
Recruiting
Multiple myeloma (MM) is the second most common hematologic malignancy in adults. The current standard of care for MM patients fit to undergo high dose conditioning chemotherapy is an autologous HCT (autoHCT). Allogeneic HCT (alloHCT) is the only potentially curative therapy available to patients with MM. However, the significant morbidity and mortality of this procedure historically limited its application in older patients. Thus, although potentially curative, standard risk MM patients have e... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/29/2023
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Multiple Myeloma
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Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis
NCT02934477
Recruiting
This observational study will compare outcomes of a prospectively-enrolled cohort of Hematopoietic Stem Cell Transplant (HCT) recipients with outcomes of a cohort of age-matched historical non-HCT controls. Patients undergoing alloHCT will receive HCT in a US transplant center and be reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) using well-established CIBMTR report forms and data collection procedures as well as a study-specific supplemental form. Data on... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
08/29/2023
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Myelofibrosis
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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Determining How Indoor Lighting Affects the Brain Health of Older Adults
NCT05978934
Recruiting
The goal of this randomized, cross-over, single-site trial followed by an exploratory third intervention is to understand how indoor lighting affects different measures of brain health in older adults living in independent living residences. This is a community based study occurring in a local senior living facility. The main question this study aims to answer is: - How does the quality of ambient indoor lighting an older adult is exposed to affect measures of brain health, such as sleep qualit... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/28/2023
Locations: The Waters on Mayowood, Rochester, Minnesota
Conditions: Sleep, Physical Activity, Cognitive Function, Social Isolation
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