Connecticut is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973
Recruiting
The objective of this study is to evaluate the efficacy and safety of sacituzumab govitecan-hziy monotherapy and with novel combinations in participants with metastatic urothelial cancer (mUC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Smilow Cancer Hospital at Yale-New Haven, New Haven, Connecticut
Conditions: Metastatic Urothelial Cancer
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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
NCT06064877
Recruiting
The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer. The primary hypothesis is that ficlatuzumab combined with cetuximab is superior to cetuximab alone in terms of progression-free survival and/or overall survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Yale School of Medicine - Smilow Cancer Hospital, New Haven, Connecticut
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
Register for Updates
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
NCT05489705
Recruiting
This registry evaluates patient characteristics, real-world treatment patterns, and short- and long-term outcomes in a population of patients in the United States and Europe with symptomatic obstructive hypertrophic cardiomyopathy (HCM) who are receiving mavacamten, receiving other treatment for obstructive HCM, or not receiving treatment for obstructive HCM due to intolerance or failure of prior treatment. United States Sub-Study: The purpose of this study is to evaluate the safety of mavacamt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Hartford HealthCare, Hartford, Connecticut
Conditions: Obstructive Hypertrophic Cardiomyopathy
Register for Updates
Substance Misuse and Family Violence Treatment Fathers
NCT06650267
Recruiting
This study involves a randomized controlled trial of Fathers for Change (F4C) compared to Individual Drug Counseling (IDC) with a sample of 280 fathers enrolled in substance use (SU) treatment within community or veterans (VA) healthcare settings to (a) demonstrate F4C efficacy compared to IDC in reducing SU and family violence (FV) at end of treatment, 3- and 6-month post-treatment follow-up, and (b) document improved emotion regulation as the mechanism within F4C that results in reduced SU and... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Yale University Child Study Center, New Haven, Connecticut
Conditions: Substance Misuse, Violence, Domestic, Child Abuse
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OMAR Opioid Use Disorder
NCT05683184
Recruiting
The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid receptor 1 (CB1R) availability.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut
Conditions: Healthy Control, Opioid Use Disorder
Register for Updates
The Recovery in Stroke Using PAP Study
NCT04130503
Recruiting
The proposed study is a randomized controlled trial among an anicipated 180 participants with acute ischemic stroke and mod/severe OSA diagnosed by ambulatory polysomnography (PSG) comparing PAP treatment with usual care concerning the primary outcome of functional recovery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Ischemic Stroke, Obstructive Sleep Apnea
Register for Updates
Type 1 Diabetes Extension Study
NCT02734277
Recruiting
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study will: * follow participants to determine how long they continue to produce insulin, and * will also assess how changes in the immune system over time relate to the ability to produce insulin. This information could help design better therapies for... Read More
Gender:
ALL
Ages:
Between 8 years and 35 years
Trial Updated:
04/09/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Type 1 Diabetes Mellitus, T1DM, T1D
Register for Updates
Impact of a Community Health Worker Strategy on Produce Prescription Program Uptake Among People With Diabetes
NCT06401668
Recruiting
Produce prescription programs (PRx) are promising interventions for improving health outcomes for patients with both type 2 diabetes (T2D) and food insecurity, but uptake has been suboptimal. There is a critical need for scalable, evidence-based implementation strategies for improving PRx uptake and optimizing the effectiveness and cost-effectiveness of these interventions. This study will co-design and pilot a community health worker (CHW) strategy and test the effectiveness of the strategy com... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: Hartford HealthCare/ St. Vincent Medical Center, Hartford, Connecticut
Conditions: Diabetes Type 2
Register for Updates
Intestinal Immunity in Neurologic Disease
NCT06329453
Recruiting
The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/08/2025
Locations: Yale MS Clinic, North Haven, Connecticut
Conditions: Multiple Sclerosis, Parkinson Disease, REM Sleep Behavior Disorder
Register for Updates
Addictive Threshold of Nicotine
NCT06096714
Recruiting
To determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, -and reinforcement in smokers with different levels of dependence.
Gender:
ALL
Ages:
Between 21 years and 59 years
Trial Updated:
04/08/2025
Locations: VA Healthcare System, West Haven, Connecticut
Conditions: Smoking Addiction
Register for Updates
Alcohol-ROC-Training
NCT05491551
Recruiting
The goal of the proposed study is to examine whether brief training in regulation of craving (ROC-T) affects alcohol drinking. The study will consist of a basic screening (phone and online), and in person visit to determine eligibility and conduct pre-intervention baseline assessments, 1-4 training (ROC-T) visits, a post-intervention assessment visit, and 1-2 phone/online follow up assessments.The two active conditions of ROC-T are based on cognitive-behavioral treatments (CBT) and mindfulness-b... Read More
Gender:
ALL
Ages:
Between 18 years and 26 years
Trial Updated:
04/08/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Binge Drinking, Heavy Drinking, Young Adult, Heavy Drinker
Register for Updates
Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke
NCT04760717
Recruiting
The purpose of this research study is to determine whether blood pressure treatment regimens with spironolactone are better than blood pressure treatment regimens without spironolactone at lowering blood pressure in stroke survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Intracerebral Hemorrhage, Spironolactone, Ischemic Stroke
Register for Updates