Connecticut is currently home to 1240 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and with Pembrolizumab
NCT04130516
Recruiting
This Phase 1/2, first-in-human, open-label, multicenter study follows a 3+3 ascending dose escalation design to determine the MTD/RP2D and to characterize the safety, tolerability, PK, and antitumor effects of LNS8801 alone and in combination with pembrolizumab. The study will include a dose escalation phase, a dose expansion phase, and phase 2A cohorts. Up to 200 patients will be accrued for this study. Up to 15 study sites in the United States will participate in the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Solid Tumor, Adult
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Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
NCT06479161
Recruiting
The primary purpose of this study is to evaluate postoperative pain. Secondary outcomes evaluated in this study will include range of motion (ROM), opioid consumption, and ambulation. Each outcome measure will be evaluated, oral tranexamic acid (TXA) in the experiment arm and placebo in the control arm, after total knee arthroplasty (TKA) at postoperative days 0-3, and weeks 1, 2, 6, and 12.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
12/09/2024
Locations: Trinity Health Of New England/CT Joint Replacement Institute, Hartford, Connecticut
Conditions: Postoperative Pain
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Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
NCT05020535
Recruiting
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Intracerebral Hemorrhage
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Observational Study of HIV+ Deceased Donor Transplant for HIV+ Recipients
NCT02602262
Recruiting
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice. Some HIV+ individuals who receive a solid organ transplant from HIV-uninfected (HIV-) donors will also be followed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Yale University School of Medicine, New Haven, Connecticut
Conditions: HIV Infection
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Brain Oxygen Optimization in Severe TBI, Phase 3
NCT03754114
Recruiting
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in s... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
12/06/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Brain Injuries, Traumatic
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Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD)
NCT01630460
Recruiting
CMD can be inherited in an autosomal dominant or recessive trait. CMD may also be caused by de novo mutations. The goal of this study is to identify genes and regulatory elements on chromosomes that are the cause for CMD. The investigators also study blood samples and tissue samples from patients to learn about the processes that lead to this disorder. The investigators long-term goal is to find mechanisms to slow down bone deposition in CMD patients.
Gender:
ALL
Ages:
All
Trial Updated:
12/06/2024
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Craniometaphyseal Dysplasia
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Genetic and Functional Analysis of Cherubism
NCT01630447
Recruiting
The goal of this research study is to identify genes and regulatory elements on chromosomes that cause cherubism. Together with the investigators collaborators the investigators also study blood samples and tissue samples from patients to learn about the processes that lead to this disorder. The long-term goal of researchers involved in this study is to find mechanisms to slow down bone resorption in cherubism patients.
Gender:
ALL
Ages:
All
Trial Updated:
12/06/2024
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Cherubism
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Genetic and Functional Analysis of Aplasia Cutis Congenital (ACC)
NCT01630421
Recruiting
The goal of this research study is to identify genes and regulatory elements on chromosomes that cause ACC. The investigators also study tissue samples from patients to learn about the processes that lead to this disorder.
Gender:
ALL
Ages:
All
Trial Updated:
12/06/2024
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Aplasia Cutis Congenita
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Genetic Analysis of Keloids
NCT01619553
Recruiting
Keloids have a strong genetic component. The goal of this study is to identify genes and regulatory elements on chromosomes that are the cause for keloids or contribute to keloid scarring.
Gender:
ALL
Ages:
All
Trial Updated:
12/06/2024
Locations: University of Connecticut Health Center (UCHC), Farmington, Connecticut
Conditions: Keloid
Register for Updates
US National OCS Heart Perfusion (OHP) Registry
NCT05915299
Recruiting
This Registry is a sponsor initiated, multi-center, observational post-approval registry with independent academic oversight.
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Heart Transplant
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Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
NCT05551325
Recruiting
More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption. Promotion of circadian alignment (i.e., alignment of the body's clocks) would make it possible to strategically schedule behaviors such as sleep and eating at normal body clock times, which is predicted to improve sleep quality and metabolic function. This project will test the ability of a sleep chronobundle (i.e., sleep... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at St Raphael's Campus, New Haven, Connecticut
Conditions: Critical Illness, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Unspecified
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Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
ALL
Ages:
Between 1 year and 120 years
Trial Updated:
12/05/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
Register for Updates